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Very long-chain fatty acids: elongation, physiology and related disorders

Journal of biochemistry (Tokyo), 2012-11, Vol.152 (5), p.387-395

Kihara, Akio

2012

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Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Biochimica et biophysica acta, 2014-05, Vol.1841 (5), p.766-772

Kihara, Akio

2014

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Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

Journal of lipid research, 2020-06, Vol.61 (6), p.884-895

2020

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PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Nature communications, 2017-03, Vol.8 (1), p.14610-14610, Article 14610

2017

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Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

The FASEB journal, 2018-06, Vol.32 (6), p.2966-2978

2018

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Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Journal of lipid research, 2024-06, Vol.65 (6), p.100550, Article 100550

2024

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Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

eLife, 2020-04, Vol.9

2020

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Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

The Journal of biological chemistry, 2016-04, Vol.291 (14), p.7477-7487

2016

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Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

Journal of dermatological science, 2021-01, Vol.101 (1), p.69-71

2021

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Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

The FASEB journal, 2022-04, Vol.36 (4), p.e22216-n/a

2022

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Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

Journal of dermatological science, 2022-08, Vol.107 (2), p.89-94

2022

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Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Biochemical journal, 2005-08, Vol.390 (Pt 1), p.263-271

2005

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Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

PloS one, 2014-07, Vol.9 (7), p.e101823-e101823

2014

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Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Biochemical and biophysical research communications, 2013-12, Vol.442 (3-4), p.195-201

2013

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Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Journal of lipid research, 2014-03, Vol.55 (3), p.524-530

2014

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Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

The Journal of biological chemistry, 2014-09, Vol.289 (36), p.24736-24748

2014

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Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

Biochimica et biophysica acta, 2008-09, Vol.1781 (9), p.496-502

2008

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Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

FEBS letters, 2011-10, Vol.585 (20), p.3337-3341

2011

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Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Journal of investigative dermatology, 2018-04, Vol.138 (4), p.741-749

2018

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Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

Molecular and Cellular Biology, 2013-07, Vol.33 (14), p.2787-2796

2013

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The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

The Journal of biological chemistry, 2017-09, Vol.292 (37), p.15538-15551

2017

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Palmitoylated calnexin is a key component of the ribosome-translocon complex

The EMBO journal, 2012-04, Vol.31 (7), p.1823-1835

2012

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Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate

Progress in lipid research, 2007-03, Vol.46 (2), p.126-144

2007

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Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast

Journal of lipid research, 2020-07, Vol.61 (7), p.1104-1114

2020

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An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

The EMBO journal, 2023-02, Vol.42 (4), p.e112275-n/a

2023

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Very long-chain fatty acids: elongation, physiology and related disorders

Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS[S]

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

Very long‐chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice

Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

Enzyme Activities of the Ceramide Synthases CERS2–6 Are Regulated by Phosphorylation in the C-terminal Region

Impaired production of the skin barrier lipid acylceramide by CYP4F22 ichthyosis mutations

Formation of fatty alcohols—components of meibum lipids—by the fatty acyl‐CoA reductase FAR2 is essential for dry eye prevention

Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Two modes of regulation of the fatty acid elongase ELOVL6 by the 3-ketoacyl-CoA reductase KAR in the fatty acid elongation cycle

Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway

Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid[S]

Dual Functions of the Trans-2-Enoyl-CoA Reductase TER in the Sphingosine 1-Phosphate Metabolic Pathway and in Fatty Acid Elongation

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720

Biochemical characterization of the very long-chain fatty acid elongase ELOVL7

Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1, the Gene Responsible for Very-Long-Chain Fatty Acid Production

The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways

Palmitoylated calnexin is a key component of the ribosome-translocon complex

Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate

Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast

An ERAD‐independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis

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