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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

Neuropharmacology, 2017-02, Vol.113 (Pt B), p.597-607

2017

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The structure and function of the S1P1 receptor

Trends in pharmacological sciences (Regular ed.), 2013-07, Vol.34 (7), p.401-412

2013

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Sphingosine 1‐phosphate receptors regulate TLR4‐induced CXCL5 release from astrocytes and microglia

Journal of neurochemistry, 2018-03, Vol.144 (6), p.736-747

2018

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Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice

Neuropsychopharmacology (New York, N.Y.), 2013-07, Vol.38 (8), p.1575-1584

2013

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Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination

PloS one, 2017-11, Vol.12 (11), p.e0187217

2017

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Making protein interactions druggable: targeting PDZ domains

Nature reviews. Drug discovery, 2004-12, Vol.3 (12), p.1047-1056

Dev, Kumlesh K

2004

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The Effects of Antipsychotics in Experimental Models of Krabbe Disease

Biomedicines, 2023-04, Vol.11 (5), p.1313

2023

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The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

Glia, 2014-05, Vol.62 (5), p.725-735

2014

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Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

Frontiers in aging neuroscience, 2018-10, Vol.10, p.332-332

2018

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The PSD-95/nNOS complex: new drugs for depression?

Pharmacology & therapeutics (Oxford), 2012-02, Vol.133 (2), p.218-229

2012

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EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

Journal of neuroinflammation, 2017-12, Vol.14 (1), p.250-250, Article 250

2017

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Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Journal of neuroinflammation, 2016-08, Vol.13 (1), p.189-189, Article 189

2016

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The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems

Current drug targets, 2016-01, Vol.17 (16), p.1851

2016

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Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors

Neuropharmacology, 2007-04, Vol.52 (5), p.1210-1218

2007

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The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices

Journal of neuroinflammation, 2017-08, Vol.14 (1), p.159-159, Article 159

2017

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The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease

Molecular neurobiology, 2024-04

2024

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Neuropathology in mice expressing mouse alpha-synuclein

PloS one, 2011-09, Vol.6 (9), p.e24834-e24834

2011

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The Expression of Neuronal Sorting Nexin 8 (SNX8) Exacerbates Abnormal Cholesterol Levels

Journal of molecular neuroscience, 2014-05, Vol.53 (1), p.125-134

2014

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Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling

Journal of cell science, 2015-11, Vol.128 (21), p.3878-3887

2015

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Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses

Pharmaceutics, 2023-01, Vol.15 (2), p.360

2023

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Phosphorylated FTY720 promotes astrocyte migration through sphingosine‐1‐phosphate receptors

Journal of neurochemistry, 2007-08, Vol.102 (4), p.1151-1161

2007

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Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease

Molecular neurobiology, 2022-03, Vol.59 (3), p.1882-1895

2022

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Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

Behavioural brain research, 2008-01, Vol.186 (1), p.126-132

2008

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Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation

Frontiers in synaptic neuroscience, 2019-04, Vol.11, p.13-13

2019

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The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Journal of neuroinflammation, 2016-02, Vol.13 (32), p.31-31, Article 31

2016

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Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

The structure and function of the S1P1 receptor

Sphingosine 1‐phosphate receptors regulate TLR4‐induced CXCL5 release from astrocytes and microglia

Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice

Phospholipase A2 is involved in galactosylsphingosine-induced astrocyte toxicity, neuronal damage and demyelination

Making protein interactions druggable: targeting PDZ domains

The Effects of Antipsychotics in Experimental Models of Krabbe Disease

The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes

The PSD-95/nNOS complex: new drugs for depression?

EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems

Phosphorylated FTY720 stimulates ERK phosphorylation in astrocytes via S1P receptors

The chemokine fractalkine (CX3CL1) attenuates H2O2-induced demyelination in cerebellar slices

The Effect of Donepezil Hydrochloride in the Twitcher Mouse Model of Krabbe Disease

Neuropathology in mice expressing mouse alpha-synuclein

The Expression of Neuronal Sorting Nexin 8 (SNX8) Exacerbates Abnormal Cholesterol Levels

Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling

Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses

Phosphorylated FTY720 promotes astrocyte migration through sphingosine‐1‐phosphate receptors

Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer’s Disease

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

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