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Structural, molecular, and functional insights into Schlafen proteins

Experimental and Molecular Medicine, 2022, 54(0), , pp.730-738

2022

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Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

Cancers, 2021-09, Vol.13 (18), p.4601

2021

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Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes

Nucleic acids research, 2021-10, Vol.49 (18), p.10493

2021

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SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243

Cancer research (Chicago, Ill.), 2021-06, Vol.81 (11), p.3067-3078

2021

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Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

Nature communications, 2023-04, Vol.14 (1), p.1925-1925, Article 1925

2023

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A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment

Scientific reports, 2019-06, Vol.9 (1), p.8726-12, Article 8726

2019

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PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress

PLoS genetics, 2016-12, Vol.12 (12), p.e1006465

2016

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Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

PLoS genetics, 2019-02, Vol.15 (2), p.e1007983-e1007983

2019

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Posttranslational regulation of Akt in human cancer

Cell & bioscience, 2014-10, Vol.4 (1), p.59-59, Article 59

2014

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Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

Molecules and Cells, 2015, 38(8), , pp.669-676

2015

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Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

iScience, 2021-10, Vol.24 (10), p.103173-103173, Article 103173

2021

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Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

iScience, 2022-11, Vol.25 (11), p.105338, Article 105338

2022

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Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C

PloS one, 2013-01, Vol.8 (1), p.e53012

2013

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Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways

DNA repair, 2020-10, Vol.94, p.102926-102926, Article 102926

2020

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Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Molecular cancer therapeutics, 2021-08, Vol.20 (8), p.1431-1441

2021

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SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (6)

2021

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Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

Molecules and cells, 2015, Vol.38 (8), p.669-676

2015

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SLFN11’s surveillance role in protein homeostasis

Oncoscience, 2022-07, Vol.9, p.35-37

2022

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TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Molecular cancer therapeutics, 2022-07, Vol.21 (7), p.1090-1102

2022

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Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.LB-121-LB-121

2020

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DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Cell reports (Cambridge), 2020-12, Vol.33 (13), p.108569-108569, Article 108569

2020

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Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1055-1055

2021

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Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20

Molecular cell, 2016-07, Vol.63 (2), p.249-260

2016

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Abstract 1403: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1403-1403

2017

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Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB301-LB301

2023

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Structural, molecular, and functional insights into Schlafen proteins

Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 11

Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1-DNA complexes

SLFN11 inactivation induces proteotoxic stress and sensitizes cancer cells to ubiquitin activating enzyme inhibitor TAK-243

Replication-associated formation and repair of human topoisomerase IIIα cleavage complexes

A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment

PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

Posttranslational regulation of Akt in human cancer

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway

Integrative epigenomic analyses of small cell lung cancer cells demonstrates the clinical translational relevance of gene body methylation

Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C

Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

SLFN11’s surveillance role in protein homeostasis

TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor

Abstract LB-121: The novel ATR inhibitor M4344 and CHK1 inhibitor SRA737 overcome chemoresistance in SLFN11-negative cells in combination treatment with DNA-damaging agents

DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks

Abstract 1055: Novel and highly potent ATR inhibitor M4344 kills cancer cells with replication stress and enhances the chemotherapeutic activity of widely used DNA damaging agents

Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20

Abstract 1403: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress

Abstract LB301: Molecular pharmacology and broad synergy of the novel ATR inhibitor M1774 with DNA damaging anticancer agents

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