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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

The EMBO journal, 2021-09, Vol.40 (17), p.e105603-n/a

2021

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Endolysosomal calcium regulation and disease

Biochemical Society transactions, 2010-12, Vol.38 (6), p.1458-1464

2010

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Regulation of TRPML1 function

Biochemical Society transactions, 2015-06, Vol.43 (3), p.442-446

2015

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Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function

The Journal of biological chemistry, 2015-06, Vol.290 (23), p.14361-14380

2015

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The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids

Toxins, 2022-12, Vol.14 (12), p.863

2022

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Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Acta neuropathologica communications, 2018-08, Vol.6 (1), p.74-74, Article 74

2018

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Enhanced calcium release in the acute neuronopathic form of Gaucher disease

Neurobiology of disease, 2005-02, Vol.18 (1), p.83-88

2005

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Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms

The Journal of biological chemistry, 2003-06, Vol.278 (26), p.23594-23599

2003

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Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

The Journal of biological chemistry, 2004-06, Vol.279 (25), p.26167-26175

2004

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Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.29496-29501

2003

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Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C

Neurobiology of disease, 2004-08, Vol.16 (3), p.654-658

2004

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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Wellcome open research, 2017-06, Vol.1, p.18-18

2017

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Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons

AMRC open research, 2020-05, Vol.2, p.21

2020

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Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis

Molecular genetics and metabolism, 2008-06, Vol.94 (2), p.204-211

2008

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Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease

Essays in biochemistry, 2020-09, Vol.64 (3), p.591-606

2020

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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Wellcome open research, 2017, Vol.1, p.18

2017

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Comparing the lysosomal biotoxicity of iron oxide nanoparticles for improved lysosomal purification

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107062, Article 107062

2023

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On the move, lysosomal CAX drives Ca^sup 2+^ transport and motility

The Journal of cell biology, 2016-03, Vol.212 (7), p.755

Lloyd-Evans, Emyr

2016

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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Biochemical journal, 2011-11, Vol.439 (3), p.349-378

2011

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Investigation of cannabidiol as a potential therapeutic in Niemann-Pick disease

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107098, Article 107098

2023

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The Batten disease associated protein CLN3 is required for the efflux of lysosomal K

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107030, Article 107030

2023

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Unbiased phenotypic drug screen for CLN3 disease

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107150, Article 107150

2023

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Lysosomal Ca 2+ Homeostasis and Signaling in Health and Disease

Cold Spring Harbor perspectives in biology, 2020-06, Vol.12 (6), p.a035311

2020

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Phosphatidic acid: an emerging versatile class of cellular mediators

Essays in biochemistry, 2020-09, Vol.64 (3), p.533-546

2020

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Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

Progress in lipid research, 2019-04, Vol.74, p.18-30

2019

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

Endolysosomal calcium regulation and disease

Regulation of TRPML1 function

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function

The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Enhanced calcium release in the acute neuronopathic form of Gaucher disease

Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin

Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons

Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis

Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

Comparing the lysosomal biotoxicity of iron oxide nanoparticles for improved lysosomal purification

On the move, lysosomal CAX drives Ca^sup 2+^ transport and motility

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Investigation of cannabidiol as a potential therapeutic in Niemann-Pick disease

The Batten disease associated protein CLN3 is required for the efflux of lysosomal K

Unbiased phenotypic drug screen for CLN3 disease

Lysosomal Ca 2+ Homeostasis and Signaling in Health and Disease

Phosphatidic acid: an emerging versatile class of cellular mediators

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

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