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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Nature reviews. Drug discovery, 2009-02, Vol.8 (2), p.139-152

2009

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Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

The Journal of immunology (1950), 2010-07, Vol.185 (1), p.605-614

2010

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Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

Clinical cancer research, 2012-03, Vol.18 (5), p.1207-1213

2012

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Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity

International journal of molecular sciences, 2020-12, Vol.21 (24), p.9401

2020

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Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12960

2021

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Nature genetics, 2008-02, Vol.40 (2), p.170-180

2008

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Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor

The Journal of immunology (1950), 2009-03, Vol.182 (5), p.3155-3164

2009

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IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

Cell reports (Cambridge), 2023-12, Vol.42 (12), p.113508-113508, Article 113508

2023

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HIF Oxygen Sensing Pathways in Lung Biology

Biomedicines, 2018-06, Vol.6 (2), p.68

2018

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Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Redox biology, 2021-12, Vol.48, p.102171-102171, Article 102171

2021

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Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

Gastroenterology (New York, N.Y. 1943), 2010-03, Vol.138 (3), p.1143-1154.e2

2010

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Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

Liver international, 2020-10, Vol.40 (10), p.2553-2567

2020

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CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

Oncoimmunology, 2017-04, Vol.6 (4), p.e1283468-e1283468

2017

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Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression

PloS one, 2011-07, Vol.6 (7), p.e22589

2011

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Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease

Cardiovascular research, 2010-11, Vol.88 (2), p.219-228

2010

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The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors

Endocrine-related cancer, 2010-12, Vol.17 (4), p.897-908

2010

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Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue

Frontiers in physiology, 2019-01, Vol.10, p.39-39

2019

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The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity

Biomedicine & pharmacotherapy, 2022-12, Vol.156, p.113972-113972, Article 113972

2022

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Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase

The Journal of biological chemistry, 2005-06, Vol.280 (25), p.24238-24244

2005

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Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells

Frontiers in physiology, 2022-09, Vol.13, p.950791-950791

2022

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Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1

Blood, 2000-06, Vol.95 (11), p.3387-3395

2000

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Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension

The Journal of biological chemistry, 2001-03, Vol.276 (13), p.10548-10555

2001

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Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes

International journal of molecular sciences, 2024-11, Vol.25 (21), p.11718

2024

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FRI-298-Hypoxia-inducible factor 2 alpha drives lipid accumulation in human hepatocytes through the fatty acid translocase CD36

Journal of hepatology, 2019-04, Vol.70 (1), p.e526-e526

2019

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Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation

Journal of allergy and clinical immunology, 2020-01, Vol.145 (1), p.199-214.e11

2020

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Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation

Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer

Differential Contribution of N- and C-Terminal Regions of HIF1α and HIF2α to Their Target Gene Selectivity

Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor

IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis

HIF Oxygen Sensing Pathways in Lung Biology

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression

Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease

The association of the angiopoietin/Tie-2 system with the development of metastasis and leukocyte migration in neuroendocrine tumors

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue

The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity

Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase

Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells

Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1

Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension

Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes

FRI-298-Hypoxia-inducible factor 2 alpha drives lipid accumulation in human hepatocytes through the fatty acid translocase CD36

Targeting L-type amino acid transporter 1 in innate and adaptive T cells efficiently controls skin inflammation

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