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Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis

Organic process research & development, 2019-04, Vol.23 (4), p.558-564

2019

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A Practical Method for Oxazole Synthesis by Cycloisomerization of Propargyl Amides

Organic letters, 2004-09, Vol.6 (20), p.3593-3595

2004

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Development of Practical Synthetic Method for the Preparation of Dolutegravir Sodium, a Potent HIV-1 Integrase Inhibitor for the Treatment of HIV Infectious Disease

Yūki gōsei kagaku kyōkaishi, 2020-01, Vol.78 (1), p.2-10

2020

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Process Optimization of Aldol-Type Reaction by Process Understanding Using in Situ IR

Organic process research & development, 2012-11, Vol.16 (11), p.1783-1786

2012

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Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore

Scientific reports, 2020-10, Vol.10 (1), p.16751-16751, Article 16751

2020

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The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death

Biochimica et biophysica acta. Bioenergetics, 2018-12, Vol.1859 (12), p.1313-1326

2018

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Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

Bioorganic & medicinal chemistry, 2001-11, Vol.9 (11), p.3065-3075

2001

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Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons

Neuroscience research, 2002-11, Vol.44 (3), p.297-304

2002

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Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-oxazolidones

Journal of organic chemistry, 1995-03, Vol.60 (5), p.1100-1101

1995

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Total synthesis of human chymase inhibitor methyllinderone and structure–activity relationships of its derivatives

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1695-1697

2001

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Over-activation of cAMP signaling increases vulnerability to hydrogen peroxide via actin rearrangement, which is inhibited by prostaglandin E2 in a mouse granulosa cell line

Journal of Medical and Dental Sciences, 2007, Vol.54(4), pp.167-176

2007

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Inhibition of atresia leading to luteinization of ovarian preovulatory follicles by NS398, a specific cyclooxygenase-2 inhibitor

Journal of Medical and Dental Sciences, 2007, Vol.54(2), pp.117-123

2007

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Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones

Bioorganic & medicinal chemistry letters, 2001-07, Vol.11 (13), p.1691-1694

2001

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The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca 2+ and Cpr3, mediating cell death

Biochimica et biophysica acta. Bioenergetics, 2018-12, Vol.1859 (12), p.1313

2018

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Development of Safe One-Pot Synthesis of N-1- and C-2-Substituted Benzimidazole via Reductive Cyclization of o-Nitroarylamine Using Na2S2O4

Organic process research & development, 2012-01, Vol.16 (1), p.96-101

2012

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Synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2397-2401

2000

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1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma

Bioorganic & medicinal chemistry letters, 2000-11, Vol.10 (21), p.2403-2406

2000

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Effects of trifluoroethanol as a co-solvent on the electrochemical oxidation of hardly oxidizable organic compounds

Journal of electroanalytical chemistry (Lausanne, Switzerland), 2001-07, Vol.507 (1), p.191-197

2001

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Development of Safe One-Pot Synthesis of N -1- and C -2-Substituted Benzimidazole via Reductive Cyclization of o -Nitroarylamine Using Na 2 S 2 O 4

Organic process research & development, 2012-01, Vol.16 (1), p.96-101

2012

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Structure and reactivity of reconstituted myoglobins: interaction between protein and polar side chain of chemically modified hemin

Inorganica Chimica Acta, 1998-07, Vol.275, p.159-167

1998

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Non-peptidic chymase inhibitors

Expert opinion on therapeutic patents, 2001-09, Vol.11 (9), p.1423-1428

Aoyama, Yasunori

2001

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Stereoselective Total Synthesis of (-)-α-Eudesmol, a P/Q-Type Calcium Channel Blocker

Synlett, 2001, Vol.2001 (9), p.1452-1454

2001

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Corrigendum to “synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors” [Bioorg. Med. Chem. Lett. 11 (2001) 2397]

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (15), p.2055-2055

2001

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Effects of trifluoroethanol as a co-solvent on the electrochemical oxidation of hardly oxidizable organic compounds: New trends in organic electrochemistry

Journal of electroanalytical chemistry (Lausanne, Switzerland), 2001, Vol.507 (1-2), p.191-197

2001

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Protein kinase C-dependent down-regulation of basic fibroblast growth factor (FGF-2) receptor by phorbol ester and epidermal growth factor in porcine granulosa cells

Endocrinology (Philadelphia), 1995-08, Vol.136 (8), p.3470

1995

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Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis

A Practical Method for Oxazole Synthesis by Cycloisomerization of Propargyl Amides

Development of Practical Synthetic Method for the Preparation of Dolutegravir Sodium, a Potent HIV-1 Integrase Inhibitor for the Treatment of HIV Infectious Disease

Process Optimization of Aldol-Type Reaction by Process Understanding Using in Situ IR

Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons

Enantioselective Synthesis of 2,3-Disubstituted Succinic Acids by Oxidative Homocoupling of Optically Active 3-Acyl-2-oxazolidones

Total synthesis of human chymase inhibitor methyllinderone and structure–activity relationships of its derivatives

Over-activation of cAMP signaling increases vulnerability to hydrogen peroxide via actin rearrangement, which is inhibited by prostaglandin E2 in a mouse granulosa cell line

Inhibition of atresia leading to luteinization of ovarian preovulatory follicles by NS398, a specific cyclooxygenase-2 inhibitor

Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones

The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca 2+ and Cpr3, mediating cell death

Development of Safe One-Pot Synthesis of N-1- and C-2-Substituted Benzimidazole via Reductive Cyclization of o-Nitroarylamine Using Na2S2O4

Synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors

1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma

Effects of trifluoroethanol as a co-solvent on the electrochemical oxidation of hardly oxidizable organic compounds

Development of Safe One-Pot Synthesis of N -1- and C -2-Substituted Benzimidazole via Reductive Cyclization of o -Nitroarylamine Using Na 2 S 2 O 4

Structure and reactivity of reconstituted myoglobins: interaction between protein and polar side chain of chemically modified hemin

Non-peptidic chymase inhibitors

Stereoselective Total Synthesis of (-)-α-Eudesmol, a P/Q-Type Calcium Channel Blocker

Corrigendum to “synthesis and structure–activity relationships of a new class of 1-oxacephem-based human chymase inhibitors” [Bioorg. Med. Chem. Lett. 11 (2001) 2397]

Effects of trifluoroethanol as a co-solvent on the electrochemical oxidation of hardly oxidizable organic compounds: New trends in organic electrochemistry

Protein kinase C-dependent down-regulation of basic fibroblast growth factor (FGF-2) receptor by phorbol ester and epidermal growth factor in porcine granulosa cells

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