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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Neuron (Cambridge, Mass.), 2016-05, Vol.90 (3), p.507-520

2016

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Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Neuron (Cambridge, Mass.), 2009-12, Vol.64 (6), p.828-840

2009

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Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

The Journal of neuroscience, 2008-11, Vol.28 (45), p.11500-11510

2008

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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Human molecular genetics, 2008-12, Vol.17 (23), p.3767-3775

2008

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

International journal of molecular sciences, 2021-08, Vol.22 (16), p.8914

2021

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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A cause for childhood ataxia

eLife, 2016-03, Vol.5

Steffan, Joan S

2016

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The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

Human molecular genetics, 2007-01, Vol.16 (1), p.61-77

2007

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Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Experimental neurology, 2021-04, Vol.338, p.113463, Article 113463

2021

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Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29427-29436

2009

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Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Journal of Huntington's disease, 2022-01, Vol.11 (1), p.25-33

2022

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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

Journal of Huntington's disease, 2018-01, Vol.7 (2), p.137-150

2018

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Nature genetics, 2002-04, Vol.30 (4), p.367-376

2002

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Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

Journal of Huntington's disease, 2018-01, Vol.7 (4), p.321-335

2018

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Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

Journal of Huntington's disease, 2012, Vol.1 (1), p.71-87

2012

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Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases

Expert opinion on therapeutic targets, 2003-04, Vol.7 (2), p.201-213

2003

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RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I

The Journal of biological chemistry, 1996-08, Vol.271 (35), p.21062-21067

1996

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Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae

Biochemistry (Easton), 1988-11, Vol.27 (22), p.8393-8400

1988

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Expression and Function of a Mislocalized Form of Peroxisomal Malate Dehydrogenase (MDH3) in Yeast (∗)

The Journal of biological chemistry, 1995-09, Vol.270 (36), p.21220-21225

1995

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Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase

The Journal of biological chemistry, 1992-12, Vol.267 (34), p.24708-24715

1992

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Expression and function of heterologous forms of malate dehydrogenase in yeast

Archives of biochemistry and biophysics, 1992-02, Vol.293 (1), p.93-102

1992

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Habitat fragmentation causes immediate and time-delayed biodiversity loss at different trophic levels

Ecology letters, 2010-05, Vol.13 (5), p.597-605

2010

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Treating the whole body in Huntington's disease

Lancet neurology, 2015-11, Vol.14 (11), p.1135-1142

2015

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Extinction debt: a challenge for biodiversity conservation

Trends in ecology & evolution (Amsterdam), 2009-10, Vol.24 (10), p.564-571

2009

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Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment

Genomics (San Diego, Calif.), 2013-09, Vol.102 (3), p.157-162

2013

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PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

A cause for childhood ataxia

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis

Serine residues 13 and 16 are key modulators of mutant huntingtin induced toxicity in Drosophila

Phosphorylation of Threonine 3: IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY

Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes

Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

Longitudinal Biochemical Assay Analysis of Mutant Huntingtin Exon 1 Protein in R6/2 Mice

Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice

Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases

RRN11 encodes the third subunit of the complex containing Rrn6p and Rrn7p that is essential for the initiation of rDNA transcription by yeast RNA polymerase I

Gene sequence and primary structure of mitochondrial malate dehydrogenase from Saccharomyces cerevisiae

Expression and Function of a Mislocalized Form of Peroxisomal Malate Dehydrogenase (MDH3) in Yeast (∗)

Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase

Expression and function of heterologous forms of malate dehydrogenase in yeast

Habitat fragmentation causes immediate and time-delayed biodiversity loss at different trophic levels

Treating the whole body in Huntington's disease

Extinction debt: a challenge for biodiversity conservation

Multiplexed deep sequencing analysis of ALK kinase domain identifies resistance mutations in relapsed patients following crizotinib treatment

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