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Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3187-3187

2018

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The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.68-68.1

2015

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Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.71-71.4

2016

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In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

Journal of cardiovascular pharmacology, 2003-07, Vol.42 (1), p.105-112

2003

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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.208-208.5|68.3

2015

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Spirocyclic ureas: Orally bioavailable 11b-HSD1 inhibitors identified by computer-aided drug design

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.881-886

2010

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4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3973-3976

1992

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Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation

Journal of medicinal chemistry, 1987-04, Vol.30 (4), p.690-695

1987

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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Circulation (New York, N.Y.), 1999-11, Vol.100 (18), p.1917-1922

1999

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Synthesis of 4,5-dihydroazepine-3,6-dicarboxylate derivatives by stereoselective ring expansion-nucleophilic addition to 4-.alpha.-chloroalkyl-1,4-dihydropyridine-3,5-dicarboxylates

Journal of organic chemistry, 1984-10, Vol.49 (20), p.3871-3874

1984

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2611

2003

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Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.283

2002

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (15), p.2611-2611

2003

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Chapter 11 - Structure-based Design Technology CONTOUR and its Application to Drug Discovery

Innovations in Biomolecular Modeling and Simulations: Volume 2, 2012, Vol.2, p.265-280

2012

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Non-peptide fibrinogen receptor antagonists. 21. The synthesis of [3H]L-738,167

Journal of labelled compounds & radiopharmaceuticals, 1998-04, Vol.41 (4), p.273-277

1998

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Preparation of 7-Alkyl-2,3,6,7-tetrahydro-4-alkyl-2-oxo- 1 H -1,3-diazepine-5-carboxylates by Ring Expansion-Nucleophilic Addition

Synthesis (Stuttgart), 1986, Vol.1986 (8), p.664-665

1986

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Reversal of the phenylseleno- and phenylsulpheno-cyclizations. Synthesis of olefins from phenylseleno- and phenylsulpheno-lactones, phenylselenoethers, and α-hydroxyselenides

Journal of the Chemical Society. Chemical communications, 1979 (2), p.83-85

1979

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Hantzsch 1,2,3,4-tetrahydropyridines related to calcium antagonists. Two synthetic approaches

Tetrahedron letters, 1985, Vol.26 (44), p.5417-5420

1985

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SYNTHESIS OF (+, -) ZOAPATANOL: SYNTHESIS OF IONOPHORE ANTIBIOTIC X-14547A, COUPLING OF RIGHT AND LEFT WINGS, TRANS BUTADIENE FORMATION, AND 2-KETOPYRROLE FORMATION. N-PHENYLSELENO PHTHALIMIDE (N-PSP) AND N-PHENYLSELENO SUCCINIMIDE (N-PSS), TWO VERSATILE CARRIERS OF THE PHENYLSELENO GROUP

CLAREMON, DAVID ALAN

1982

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ChemInform Abstract: Pyridazine Based Inhibitors of p38 MAPK

ChemInform, 2002-07, Vol.33 (26), p.no-no

2002

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Carbocyclic thromboxane A 2: Aggrevation of myocardial ischemia by a new synthetic thromboxane A 2 analog

Prostaglandins, 1981, Vol.21 (3), p.443-456

1981

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Carbocyclic thromboxane A2: aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog

Prostaglandins, 1981-03, Vol.21 (3), p.443-456

1981

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Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia

The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

Spirocyclic ureas: Orally bioavailable 11b-HSD1 inhibitors identified by computer-aided drug design

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation

Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Synthesis of 4,5-dihydroazepine-3,6-dicarboxylate derivatives by stereoselective ring expansion-nucleophilic addition to 4-.alpha.-chloroalkyl-1,4-dihydropyridine-3,5-dicarboxylates

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Chapter 11 - Structure-based Design Technology CONTOUR and its Application to Drug Discovery

Non-peptide fibrinogen receptor antagonists. 21. The synthesis of [3H]L-738,167

Preparation of 7-Alkyl-2,3,6,7-tetrahydro-4-alkyl-2-oxo- 1 H -1,3-diazepine-5-carboxylates by Ring Expansion-Nucleophilic Addition

Reversal of the phenylseleno- and phenylsulpheno-cyclizations. Synthesis of olefins from phenylseleno- and phenylsulpheno-lactones, phenylselenoethers, and α-hydroxyselenides

Hantzsch 1,2,3,4-tetrahydropyridines related to calcium antagonists. Two synthetic approaches

SYNTHESIS OF (+, -) ZOAPATANOL: SYNTHESIS OF IONOPHORE ANTIBIOTIC X-14547A, COUPLING OF RIGHT AND LEFT WINGS, TRANS BUTADIENE FORMATION, AND 2-KETOPYRROLE FORMATION. N-PHENYLSELENO PHTHALIMIDE (N-PSP) AND N-PHENYLSELENO SUCCINIMIDE (N-PSS), TWO VERSATILE CARRIERS OF THE PHENYLSELENO GROUP

ChemInform Abstract: Pyridazine Based Inhibitors of p38 MAPK

Carbocyclic thromboxane A 2: Aggrevation of myocardial ischemia by a new synthetic thromboxane A 2 analog

Carbocyclic thromboxane A2: aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog

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