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An electronic environment and contact direction sensitive scoring function for predicting affinities of protein–ligand complexes in Contour

Journal of molecular graphics & modelling, 2014-09, Vol.53, p.118-127

2014

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Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3187-3187

2018

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Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

Biochemistry (Easton), 1994-08, Vol.33 (33), p.10109-10119

1994

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The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.68-68.1

2015

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Abstract 334: The LXRβ Selective Agonist, VTP-38443, Significantly Decreases Plaque Cholesterol Ester Content and Inflammation in a Murine Model of Accelerated Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2015-05, Vol.35 (suppl_1)

2015

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Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.71-71.4

2016

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In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

Journal of cardiovascular pharmacology, 2003-07, Vol.42 (1), p.105-112

2003

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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.208-208.5|68.3

2015

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Organolithium addition to aldehyde dimethylhydrazones: a highly diastereocontrolled synthesis of threo 2-amino alcohols, and (1R,2R)-(-)-norpseudoephedrine

Journal of the American Chemical Society, 1986-12, Vol.108 (26), p.8265-8266

1986

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Spirocyclic ureas: Orally bioavailable 11b-HSD1 inhibitors identified by computer-aided drug design

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.881-886

2010

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4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3973-3976

1992

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Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation

Journal of medicinal chemistry, 1987-04, Vol.30 (4), p.690-695

1987

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Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Circulation (New York, N.Y.), 1999-11, Vol.100 (18), p.1917-1922

1999

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Antiarrhythmic Efficacy of Selective Blockade of the Cardiac Slowly Activating Delayed Rectifier Current, I Ks , in Canine Models of Malignant Ischemic Ventricular Arrhythmia

Circulation (New York, N.Y.), 1999-11, Vol.100 (18), p.1917-1922

1999

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Synthesis of 4,5-dihydroazepine-3,6-dicarboxylate derivatives by stereoselective ring expansion-nucleophilic addition to 4-.alpha.-chloroalkyl-1,4-dihydropyridine-3,5-dicarboxylates

Journal of organic chemistry, 1984-10, Vol.49 (20), p.3871-3874

1984

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (15), p.2611

2003

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Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.283

2002

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Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1165-1168

2003

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Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (15), p.2611-2611

2003

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Inhibition of Factor XIIIa in a Canine Model of Coronary Thrombosis: Effect on Reperfusion and Acute Reocclusion After Recombinant Tissue-Type Plasminogen Activator

Blood, 1990-04, Vol.75 (7), p.1455-1459

1990

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An efficient chemoselective synthesis of nitriles from primary amides

Tetrahedron letters, 1988, Vol.29 (18), p.2155-2158

1988

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Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

Tetrahedron letters, 1996-09, Vol.37 (37), p.6685-6688

1996

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Dissociation of Vasoconstrictor and Platelet Aggregatory Activities of Thromboxane by Carbocyclic Thromboxane A2, a Stable Analog of Thromboxane A2

Proceedings of the National Academy of Sciences - PNAS, 1980-03, Vol.77 (3), p.1706-1710

1980

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An electronic environment and contact direction sensitive scoring function for predicting affinities of protein–ligand complexes in Contour

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Abstract 3187: Pediatric Preclinical Testing Consortium evaluation of the menin inhibitor, VTP-50469, against xenograft models of MLL-rearranged infant acute lymphoblastic leukemia

Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZ

Transglutaminase Inhibition by 2-[(2-Oxopropyl)thio]imidazolium Derivatives: Mechanism of Factor XIIIa Inactivation

The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

Abstract 334: The LXRβ Selective Agonist, VTP-38443, Significantly Decreases Plaque Cholesterol Ester Content and Inflammation in a Murine Model of Accelerated Atherosclerosis

Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

In Vivo Canine Cardiac Electrophysiologic Profile of 1,4-Benzodiazepine Iks Blockers

VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

Organolithium addition to aldehyde dimethylhydrazones: a highly diastereocontrolled synthesis of threo 2-amino alcohols, and (1R,2R)-(-)-norpseudoephedrine

Spirocyclic ureas: Orally bioavailable 11b-HSD1 inhibitors identified by computer-aided drug design

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Diethyl 3,6-dihydro-2,4-dimethyl-2,6-methano-1,3-benzothiazocine-5,11-dicarboxylates as calcium entry antagonists: new conformationally restrained analogs of Hantzsch 1,4-dihydropyridines related to nitrendipine as probes for receptor-site conformation

Antiarrhythmic efficacy of selective blockade of the cardiac slowly activating delayed rectifier current, I(Ks), in canine models of malignant ischemic ventricular arrhythmia

Antiarrhythmic Efficacy of Selective Blockade of the Cardiac Slowly Activating Delayed Rectifier Current, I Ks , in Canine Models of Malignant Ischemic Ventricular Arrhythmia

Synthesis of 4,5-dihydroazepine-3,6-dicarboxylate derivatives by stereoselective ring expansion-nucleophilic addition to 4-.alpha.-chloroalkyl-1,4-dihydropyridine-3,5-dicarboxylates

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective IKs-Blocking Class III Antiarrhythmic Agents’

Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade

Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents

Corrigendum to ‘Novel 5-Cyclopropyl-1,4-benzodiazepine-2-ones as Potent and Selective I Ks-Blocking Class III Antiarrhythmic Agents’ : [Bioorg. Med. Chem. Lett. 13 (2003) 1165]

Inhibition of Factor XIIIa in a Canine Model of Coronary Thrombosis: Effect on Reperfusion and Acute Reocclusion After Recombinant Tissue-Type Plasminogen Activator

An efficient chemoselective synthesis of nitriles from primary amides

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

Dissociation of Vasoconstrictor and Platelet Aggregatory Activities of Thromboxane by Carbocyclic Thromboxane A2, a Stable Analog of Thromboxane A2

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