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Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Cell stem cell, 2014-01, Vol.14 (1), p.68-80

2014

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Cell chemical biology, 2020-01, Vol.27 (1), p.41-46.e17

2020

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Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF -Mutant Melanoma

Clinical cancer research, 2020-01, Vol.26 (1), p.46-53

2020

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Outcome-Driven Cluster Analysis with Application to Microarray Data

PloS one, 2015-11, Vol.10 (11), p.e0141874-e0141874

2015

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Phase III Trial Comparing Concurrent Biochemotherapy With Cisplatin, Vinblastine, Dacarbazine, Interleukin-2, and Interferon Alfa-2b With Cisplatin, Vinblastine, and Dacarbazine Alone in Patients With Metastatic Malignant Melanoma (E3695): A Trial Coordinated by the Eastern Cooperative Oncology Group

Journal of clinical oncology, 2008-12, Vol.26 (35), p.5748-5754

2008

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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

Journal of medicinal chemistry, 2021-12, Vol.64 (23), p.17146-17183

2021

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B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell Lymphoma

The American journal of surgical pathology, 2010-03, Vol.34 (3), p.327-340

2010

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A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer

The oncologist (Dayton, Ohio), 2017-03, Vol.22 (3), p.264-271

2017

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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

Bioorganic & medicinal chemistry letters, 2021-05, Vol.39, p.127904-127904, Article 127904

2021

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BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

Cancer research (Chicago, Ill.), 2008-08, Vol.68 (16), p.6507-6515

2008

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Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma

Neuro-oncology (Charlottesville, Va.), 2015-05, Vol.17 (5), p.697-707

2015

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Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600 -mutated Metastatic Melanoma

Clinical cancer research, 2019-06, Vol.25 (11), p.3239-3246

2019

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Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program

PloS one, 2015-10, Vol.10 (10), p.e0139679

2015

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Informatively clustering longitudinal microarrays using binary or survival outcome data

Communication in statistics. Case studies and data analysis, 2018-01, Vol.4 (1), p.18-27

2018

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Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

Clinical cancer research, 2011, Vol.17 (1), p.56-66

2011

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Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Journal of medicinal chemistry, 2024-06, Vol.67 (11), p.8962-8987

2024

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Diverse Drug Combinations with an Eed Inhibitor Confer Context-Specific Benefit across Multiple Tumor Types

Blood, 2021-11, Vol.138 (Supplement 1), p.2274-2274

2021

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5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAFV600 Mutation-Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

Clinical cancer research, 2021-10, Vol.27 (19), p.5225-5235

2021

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5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAF V600 Mutation–Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

Clinical cancer research, 2021-10, Vol.27 (19), p.5225-5235

2021

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Varied Clinical Ketogenic Diets Elicit Both Shared and Unique Functional and Taxonomic Responses on the Human Gut Microbiome in Refractory Epilepsy

Current developments in nutrition, 2022-06, Vol.6 (Supplement_1), p.1024-1024

2022

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Extended 5-Year Follow-Up Results of a Phase 1b Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma

Clinical cancer research, 2019-11, Vol.26 (1), p.46-53

2019

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Dietary Fibers in Clinical Ketogenic Diets Promotes Seizure Resistance in Mice Through Modulation of Gut Microbiome

Current developments in nutrition, 2024-07, Vol.8, p.103439, Article 103439

2024

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COLET (NCT02322814): A multistage, phase 2 study evaluating the safety and efficacy of cobimetinib (C) in combination with paclitaxel (P) as first-line treatment for patients (pts) with metastatic triple-negative breast cancer (TNBC)

Journal of clinical oncology, 2016-05, Vol.34 (15_suppl), p.TPS1100-TPS1100

2016

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Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

Extended 5-Year Follow-up Results of a Phase Ib Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF -Mutant Melanoma

Outcome-Driven Cluster Analysis with Application to Microarray Data

Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase

B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell Lymphoma

A Phase II Randomized Trial (GO27827) of First‐Line FOLFOX Plus Bevacizumab with or Without the MET Inhibitor Onartuzumab in Patients with Metastatic Colorectal Cancer

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase

BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma

Genomic Features of Exceptional Response in Vemurafenib ± Cobimetinib-treated Patients with BRAF V600 -mutated Metastatic Melanoma

Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program

Informatively clustering longitudinal microarrays using binary or survival outcome data

Cobimetinib combined with vemurafenib in advanced BRAFV600 -mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

Diverse Drug Combinations with an Eed Inhibitor Confer Context-Specific Benefit across Multiple Tumor Types

5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAFV600 Mutation-Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

5-Year Outcomes with Cobimetinib plus Vemurafenib in BRAF V600 Mutation–Positive Advanced Melanoma: Extended Follow-up of the coBRIM Study

Varied Clinical Ketogenic Diets Elicit Both Shared and Unique Functional and Taxonomic Responses on the Human Gut Microbiome in Refractory Epilepsy

Extended 5-Year Follow-Up Results of a Phase 1b Study (BRIM7) of Vemurafenib and Cobimetinib in BRAF-Mutant Melanoma

Dietary Fibers in Clinical Ketogenic Diets Promotes Seizure Resistance in Mice Through Modulation of Gut Microbiome

COLET (NCT02322814): A multistage, phase 2 study evaluating the safety and efficacy of cobimetinib (C) in combination with paclitaxel (P) as first-line treatment for patients (pts) with metastatic triple-negative breast cancer (TNBC)

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