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Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

Advanced drug delivery reviews, 2009-07, Vol.61 (7), p.554-571

2009

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DNp73 Exerts Function in Metastasis Initiation by Disconnecting the Inhibitory Role of EPLIN on IGF1R-AKT/STAT3 Signaling

Cancer cell, 2013-10, Vol.24 (4), p.512-527

2013

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Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (5), p.1674-1674

2014

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Targeting of autoantigens to DEC205⁺ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice

The Journal of immunology (1950), 2013-09, Vol.191 (6), p.2938-2947

2013

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Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics

mAbs, 2021-01, Vol.13 (1), p.1982447-1982447

2021

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Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses

Nucleic acids research, 2012-11, Vol.40 (21), p.e167-e167

2012

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Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

Molecular therapy. Oncolytics, 2017-03, Vol.4 (C), p.77-86

2017

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Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

Molecular therapy. Methods & clinical development, 2016-01, Vol.3 (C), p.16018-16018, Article 16018

2016

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German Cancer Consortium (DKTK) – A national consortium for translational cancer research

Molecular oncology, 2019-03, Vol.13 (3), p.535-542

2019

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Virotherapy Research in Germany: From Engineering to Translation

Human gene therapy, 2017-10, Vol.28 (10), p.800-819

2017

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Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies

International journal of hyperthermia, 2011-09, Vol.27 (6), p.591-603

2011

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CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

Molecular therapy, 2014-11, Vol.22 (11), p.1949-1959

2014

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Multiple Interferon Regulatory Factor and NF-κB Sites Cooperate in Mediating Cell-Type- and Maturation-Specific Activation of the Human CD83 Promoter in Dendritic Cells

Molecular and Cellular Biology, 2013-04, Vol.33 (7), p.1331-1344

2013

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Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds

PloS one, 2014-04, Vol.9 (4), p.e95723-e95723

2014

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Inhibition of Melanoma Growth by Targeting of Antigen to Dendritic Cells via an Anti-DEC-205 Single-Chain Fragment Variable Molecule

Clinical cancer research, 2008-12, Vol.14 (24), p.8169-8177

2008

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Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells

International journal of cancer, 2015-08, Vol.137 (4), p.978-990

2015

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Virus chimeras for gene therapy, vaccination, and oncolysis: adenoviruses and beyond

Trends in molecular medicine, 2012-07, Vol.18 (7), p.365-376

2012

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Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation

Journal of Immunology Research, 2016-01, Vol.2016 (2016), p.1-17

2016

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Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis

PloS one, 2011-11, Vol.6 (11), p.e27934-e27934

2011

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Gene Therapy "Made in Germany": A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy

Human gene therapy, 2021-10, Vol.32 (19-20), p.987-996

2021

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Triple-Targeted Oncolytic Adenoviruses Featuring the Cox2 Promoter, E1A Transcomplementation, and Serotype Chimerism for Enhanced Selectivity for Ovarian Cancer Cells

Molecular therapy, 2006-08, Vol.14 (2), p.164-174

2006

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Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM‐CSF: Results in vitro, in rodents and in humans

International journal of cancer, 2015-10, Vol.137 (7), p.1775-1783

2015

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Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy

Oncotarget, 2015-02, Vol.6 (6), p.4467-4481

2015

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Virotherapeutics: conditionally replicative adenoviruses for viral oncolysis

Anti-cancer drugs, 2003-09, Vol.14 (8), p.577-584

Nettelbeck, Dirk M

2003

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Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

DNp73 Exerts Function in Metastasis Initiation by Disconnecting the Inhibitory Role of EPLIN on IGF1R-AKT/STAT3 Signaling

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

Targeting of autoantigens to DEC205⁺ dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice

Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics

Synthetic riboswitches for external regulation of genes transferred by replication-deficient and oncolytic adenoviruses

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

Virotherapy in Germany-Recent Activities in Virus Engineering, Preclinical Development, and Clinical Studies

German Cancer Consortium (DKTK) – A national consortium for translational cancer research

Virotherapy Research in Germany: From Engineering to Translation

Mild hyperthermia enhances human monocyte-derived dendritic cell functions and offers potential for applications in vaccination strategies

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

Multiple Interferon Regulatory Factor and NF-κB Sites Cooperate in Mediating Cell-Type- and Maturation-Specific Activation of the Human CD83 Promoter in Dendritic Cells

Adenoviruses using the cancer marker EphA2 as a receptor in vitro and in vivo by genetic ligand insertion into different capsid scaffolds

Inhibition of Melanoma Growth by Targeting of Antigen to Dendritic Cells via an Anti-DEC-205 Single-Chain Fragment Variable Molecule

Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells

Virus chimeras for gene therapy, vaccination, and oncolysis: adenoviruses and beyond

Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation

Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis

Gene Therapy "Made in Germany": A Historical Perspective, Analysis of the Status Quo, and Recommendations for Action by the German Society for Gene Therapy

Triple-Targeted Oncolytic Adenoviruses Featuring the Cox2 Promoter, E1A Transcomplementation, and Serotype Chimerism for Enhanced Selectivity for Ovarian Cancer Cells

Treatment of melanoma with a serotype 5/3 chimeric oncolytic adenovirus coding for GM‐CSF: Results in vitro, in rodents and in humans

Immunological data from cancer patients treated with Ad5/3-E2F-Δ24-GMCSF suggests utility for tumor immunotherapy

Virotherapeutics: conditionally replicative adenoviruses for viral oncolysis

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