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Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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Structural basis for GPR40 allosteric agonism and incretin stimulation

Nature communications, 2018-04, Vol.9 (1), p.1645-11, Article 1645

2018

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Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5904-5910

2016

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Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1377-1380

2015

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The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (23), p.4235-4239

2003

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Design, synthesis, and conformational analysis of a novel spiro-bicyclic system as a type II .beta.-turn peptidomimetic

Journal of the American Chemical Society, 1992-11, Vol.114 (23), p.8778-8783

1992

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Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9768-9772

2015

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Design, synthesis, and x-ray crystallographic analysis of two novel spirolactam systems as .beta.-turn mimics

Journal of organic chemistry, 1993-02, Vol.58 (4), p.860-866

1993

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Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2

Journal of medicinal chemistry, 1993-10, Vol.36 (22), p.3481-3483

1993

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Synthesis and crystal structure of a peptidomimetic containing the (R)-4.4-spiro lactam type-II .beta.-turn mimic

Journal of organic chemistry, 1993-04, Vol.58 (8), p.2334-2337

1993

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Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus i nfluenzae and Moraxella c atarrhalis

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.953-970

2000

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Recent progress with oxazolidinone antibacterial agents

Expert opinion on therapeutic patents, 2000-09, Vol.10 (9), p.1405-1414

Genin, Michael J

2000

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Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate

Journal of medicinal chemistry, 1993-05, Vol.36 (10), p.1505-1508

1993

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Application of conformationally restricted peptidomimetics to modeling the bound conformation of peptide antagonists with the IL-1 receptor

International journal of peptide research and therapeutics, 1998-05, Vol.5 (2-3), p.93-100

1998

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Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogs and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)carbonyl]-4-[3-[(1-methylethyl)amino]pyridinyl]piperazinemonomethanesulfonate (U-90152S), a second-generation clinical candidate

Journal of medicinal chemistry, 1993-05, Vol.36 (10), p.1505-1508

1993

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An improved method of oxazolidinone hydrolysis in the asymmetric synthesis of α-alkylprolines

Tetrahedron letters, 1994-07, Vol.35 (28), p.4967-4968

1994

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Design and synthesis of a conformationally constrained analog of the bis(heteroaryl)piperazine (BHAP) HIV-1 reverse transcriptase inhibitor atevirdine

Bioorganic & medicinal chemistry letters, 1995-08, Vol.5 (16), p.1875-1880

1995

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A novel method for the t-butylation of aromatic amines

Tetrahedron letters, 1993-07, Vol.34 (27), p.4301-4304

1993

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ChemInform Abstract: Substituent Effects on the Antibacterial Activity of Nitrogen-Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

ChemInform, 2000-05, Vol.31 (22), p.no-no

2000

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A mechanism for effective cell-seeding in rigid, microporous substrates

Acta biomaterialia, 2013-08, Vol.9 (8), p.7977-7986

2013

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Quantitative assessment of organ distribution of dietary protein-bound C-13-labeled N-epsilon-carboxymethyllysine after a chronic oral exposure in mice

Molecular nutrition & food research, 2016-11, Vol.60 (11), p.2446-2456

2016

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Prolonged increase in psychotropic drug use among young women following the COVID-19 pandemic: a French nationwide retrospective study

BMC medicine, 2024-07, Vol.22 (1), p.1-10, Article 274

2024

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Secondary Use of Healthcare Structured Data: The Challenge of Domain-Knowledge Based Extraction of Features

Studies in health technology and informatics, 2018, Vol.255, p.15

2018

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Plasma Levels of Free NƐ-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans

Nutrients, 2022-04, Vol.14 (9), p.1890

2022

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Adaptive Stress Testing: Finding Likely Failure Events with Reinforcement Learning

The Journal of artificial intelligence research, 2020-12, Vol.69, p.1165-1201

2020

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Discovery of 6‑(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl‑1H‑indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Structural basis for GPR40 allosteric agonism and incretin stimulation

Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Design, synthesis, and conformational analysis of a novel spiro-bicyclic system as a type II .beta.-turn peptidomimetic

Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1 H -indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia

Design, synthesis, and x-ray crystallographic analysis of two novel spirolactam systems as .beta.-turn mimics

Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro-Leu-Gly-NH2

Synthesis and crystal structure of a peptidomimetic containing the (R)-4.4-spiro lactam type-II .beta.-turn mimic

Substituent Effects on the Antibacterial Activity of Nitrogen−Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus i nfluenzae and Moraxella c atarrhalis

Recent progress with oxazolidinone antibacterial agents

Application of conformationally restricted peptidomimetics to modeling the bound conformation of peptide antagonists with the IL-1 receptor

An improved method of oxazolidinone hydrolysis in the asymmetric synthesis of α-alkylprolines

Design and synthesis of a conformationally constrained analog of the bis(heteroaryl)piperazine (BHAP) HIV-1 reverse transcriptase inhibitor atevirdine

A novel method for the t-butylation of aromatic amines

ChemInform Abstract: Substituent Effects on the Antibacterial Activity of Nitrogen-Carbon-Linked (Azolylphenyl)oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis

A mechanism for effective cell-seeding in rigid, microporous substrates

Quantitative assessment of organ distribution of dietary protein-bound C-13-labeled N-epsilon-carboxymethyllysine after a chronic oral exposure in mice

Prolonged increase in psychotropic drug use among young women following the COVID-19 pandemic: a French nationwide retrospective study

Secondary Use of Healthcare Structured Data: The Challenge of Domain-Knowledge Based Extraction of Features

Plasma Levels of Free NƐ-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans

Adaptive Stress Testing: Finding Likely Failure Events with Reinforcement Learning

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