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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

The Journal of clinical investigation, 2003-11, Vol.112 (9), p.1300-1307

2003

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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

The Journal of clinical investigation, 2003-11, Vol.112 (9), p.1300-1307

2003

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Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

The Journal of pharmacology and experimental therapeutics, 2014-09, Vol.350 (3), p.589

2014

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Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr−/− Mice

Antimicrobial Agents and Chemotherapy, 2007-10, Vol.51 (10), p.3677-3687

2007

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Alginate Overproduction Affects Pseudomonas aeruginosa Biofilm Structure and Function

Journal of Bacteriology, 2001-09, Vol.183 (18), p.5395-5401

2001

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High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

Acta pharmacologica Sinica, 2015-07, Vol.36 (7), p.874-878

2015

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Anaerobic Survival of Pseudomonas aeruginosa by Pyruvate Fermentation Requires an Usp-Type Stress Protein

Journal of Bacteriology, 2006-01, Vol.188 (2), p.659-668

2006

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Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

Infection and Immunity, 2005-04, Vol.73 (4), p.2504-2514

2005

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Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

Environmental microbiology, 2003-12, Vol.5 (12), p.1350-1369

2003

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A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm

Environmental microbiology, 2000-10, Vol.2 (5), p.530-541

2000

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Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

ACS medicinal chemistry letters, 2011-04, Vol.2 (4), p.303-306

2011

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

The EMBO journal, 2003-08, Vol.22 (15), p.3803-3815

2003

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Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10312-10332

2021

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Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2022-07, Vol.130 (7), p.458-476

2022

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Abnormal visual gain control in a Parkinson's disease model

Human molecular genetics, 2014-09, Vol.23 (17), p.4465-4478

2014

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Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.8945-8962

2017

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The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4500-4505

2017

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Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6386-6397

2010

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Quorum Sensing Regulation in Aeromonas hydrophila

Journal of molecular biology, 2010-03, Vol.396 (4), p.849-857

2010

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Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Frontiers in cellular neuroscience, 2016-06, Vol.10, p.164-164

2016

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Quorum sensing : a novel target for the treatment of biofilm infections

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2003-01, Vol.17 (4), p.241-250

2003

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3275-3278

2009

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Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6386-6397

2010

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Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Antimicrobial agents and chemotherapy, 2007-10, Vol.51 (10), p.3677-3687

2007

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Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

Infection and immunity, 2005-08, Vol.73 (8), p.5290-5290

2005

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Dose-Response Relationship, Drug
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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator

Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr−/− Mice

Alginate Overproduction Affects Pseudomonas aeruginosa Biofilm Structure and Function

High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

Anaerobic Survival of Pseudomonas aeruginosa by Pyruvate Fermentation Requires an Usp-Type Stress Protein

Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

Abnormal visual gain control in a Parkinson's disease model

Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors

Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Quorum Sensing Regulation in Aeromonas hydrophila

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Quorum sensing : a novel target for the treatment of biofilm infections

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

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