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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

The Journal of clinical investigation, 2003-11, Vol.112 (9), p.1300-1307

2003

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Anaerobic Survival of Pseudomonas aeruginosa by Pyruvate Fermentation Requires an Usp-Type Stress Protein

Journal of Bacteriology, 2006-01, Vol.188 (2), p.659-668

2006

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Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

Environmental microbiology, 2003-12, Vol.5 (12), p.1350-1369

2003

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A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm

Environmental microbiology, 2000-10, Vol.2 (5), p.530-541

2000

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Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

ACS medicinal chemistry letters, 2011-04, Vol.2 (4), p.303-306

2011

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

The EMBO journal, 2003-08, Vol.22 (15), p.3803-3815

2003

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Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10312-10332

2021

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Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2022-07, Vol.130 (7), p.458-476

2022

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Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6386-6397

2010

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Quorum Sensing Regulation in Aeromonas hydrophila

Journal of molecular biology, 2010-03, Vol.396 (4), p.849-857

2010

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Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Frontiers in cellular neuroscience, 2016-06, Vol.10, p.164-164

2016

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Quorum sensing : a novel target for the treatment of biofilm infections

BioDrugs : clinical immunotherapeutics, biopharmaceuticals, and gene therapy, 2003-01, Vol.17 (4), p.241-250

2003

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3275-3278

2009

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Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Antimicrobial agents and chemotherapy, 2007-10, Vol.51 (10), p.3677-3687

2007

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Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

Infection and immunity, 2005-08, Vol.73 (8), p.5290-5290

2005

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Antisense Silencing of the creA Gene inAspergillus nidulans

Applied and Environmental Microbiology, 2000-10, Vol.66 (10), p.4579

2000

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Targeting Quorum Sensing for Treatment of Chronic Bacterial Biofilm Infections

Laboratory medicine, 2002-04, Vol.33 (4), p.295-306

2002

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[12] Genetic and chemical tools for investigating signaling processes in biofilms

Methods in Enzymology, 2001, Vol.336, p.108,IN3-128,IN4

2001

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QUORUM SENSING IN BIOFILMS: GOSSIP IN SLIME CITY

Microbial Biofilms, 2004, p.118-140

2004

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Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections

Anaerobic Survival of Pseudomonas aeruginosa by Pyruvate Fermentation Requires an Usp-Type Stress Protein

Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics

A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm

Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

Design and Synthesis of Pyrrolo[2,3‑d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate

Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection: significance of macrolide treatment

Discovery of N -{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M 1 Receptor Agonist with Unprecedented Selectivity and Procognitive Potential

Quorum Sensing Regulation in Aeromonas hydrophila

Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

Quorum sensing : a novel target for the treatment of biofilm infections

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Azithromycin Blocks Quorum Sensing and Alginate Polymer Formation and Increases the Sensitivity to Serum and Stationary-Growth-Phase Killing of Pseudomonas aeruginosa and Attenuates Chronic P. aeruginosa Lung Infection in Cftr super(-) super(/) super(-) Mice

Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

Antisense Silencing of the creA Gene inAspergillus nidulans

Targeting Quorum Sensing for Treatment of Chronic Bacterial Biofilm Infections

[12] Genetic and chemical tools for investigating signaling processes in biofilms

QUORUM SENSING IN BIOFILMS: GOSSIP IN SLIME CITY

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