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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

PloS one, 2012-04, Vol.7 (4), p.e34822

2012

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.1005-1015

2003

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243-253

2005

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1616-1620

2014

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Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Proceedings of the National Academy of Sciences - PNAS, 1998-03, Vol.95 (7), p.3555-3560

1998

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Drug metabolism and disposition, 2012-03, Vol.40 (3), p.625-634

2012

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Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2677-2686

2000

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IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240-1250

2003

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Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Journal of medicinal chemistry, 2009-12, Vol.52 (23), p.7446-7457

2009

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Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Proceedings of the National Academy of Sciences - PNAS, 1996-05, Vol.93 (10), p.4644-4648

1996

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5886-5887

1991

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The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Proceedings of the National Academy of Sciences - PNAS, 1995-04, Vol.92 (9), p.3764-3768

1995

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Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1463-1470

2001

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The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Journal of the American Chemical Society, 1991-11, Vol.113 (23), p.9009-9009

1991

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Catalysis by Cytochrome P-450 of an Oxidative Reaction in Xenobiotic Aldehyde Metabolism: Deformylation with Olefin Formation

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (20), p.8963-8966

1991

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A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

Journal of organic chemistry, 1984-04, Vol.49 (7), p.1286-1288

1984

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In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

Drug metabolism and disposition, 2003-10, Vol.31 (10), p.1240

2003

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Evidence for a Role of a Perferryl-Oxygen Complex, FeO3+, in the N-Oxygenation of Amines by Cytochrome P450 Enzymes

Molecular pharmacology, 1997-01, Vol.51 (1), p.147-151

1997

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Peroxidative reactions of diversozymes1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Peroxidative reactions of diversozymes 1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Molecular etiology of atherogenesis--in vitro induction of lipidosis in macrophages with a new LDL model

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Epoxidation of Olefins by Cytochrome P450: Evidence from Site-Specific Mutagenesis for Hydroperoxo-Iron as an Electrophilic Oxidant

Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Peroxo-Iron and Oxenoid-Iron Species as Alternative Oxygenating Agents in Cytochrome P450-Catalyzed Reactions: Switching by Threonine-302 to Alanine Mutagenesis of Cytochrome P450 2B4

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

The use of 18O-exchange and base-catalyzed N-dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Inactivation of Ethanol-Inducible Cytochrome P450 and Other Microsomal P450 Isozymes by Trans-4-Hydroxy-2-Nonenal, a Major Product of Membrane Lipid Peroxidation

Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Catalysis by Cytochrome P-450 of an Oxidative Reaction in Xenobiotic Aldehyde Metabolism: Deformylation with Olefin Formation

A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

Evidence for a Role of a Perferryl-Oxygen Complex, FeO3+, in the N-Oxygenation of Amines by Cytochrome P450 Enzymes

Peroxidative reactions of diversozymes1

Peroxidative reactions of diversozymes 1

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