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Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors

Bioorganic & medicinal chemistry, 2024-05, Vol.106, p.117749-117749, Article 117749

2024

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Discovery of novel pyridone-benzamide derivatives possessing a 1-methyl-2-benzimidazolinone moiety as potent EZH2 inhibitors for the treatment of B-cell lymphomas

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117725-117725, Article 117725

2024

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A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9′,2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4538-4543

2008

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Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds

Bioorganic & medicinal chemistry, 2024-05, Vol.105, p.117734-117734, Article 117734

2024

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Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.16 (7), p.3907-3916

2008

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Thiophene containing triarylmethanes as antitubercular agents

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.289-292

2008

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Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Bioorganic & medicinal chemistry, 2008, Vol.18 (1), p.423-426

2008

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Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

Bioorganic & medicinal chemistry, 2008-08, Vol.18 (15), p.4388-4392

2008

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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6501-6504

2008

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Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5452-5460

2017

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Small molecule enabled chemical biology and drug discovery

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (11), p.2815-2816

Lei, Xiaoguang

2017

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Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.918-922

2008

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Discovery of indole-2-one derivatives as BRD4 (BD1) selective inhibitors

Bioorganic & medicinal chemistry, 2024-05, Vol.106, p.117752-117752, Article 117752

2024

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cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2- α]pyridine

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6513-6516

2008

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Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2- a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2- a]pyridines

Bioorganic & medicinal chemistry, 2008-01, Vol.16 (2), p.683-691

2008

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Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile

Bioorganic & medicinal chemistry, 2021-12, Vol.52, p.116503-116503, Article 116503

2021

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Synthesis and evaluation of isosteres of N-methyl indolo[3,2- b]-quinoline (cryptolepine) as new antiinfective agents

Bioorganic & medicinal chemistry, 2007-01, Vol.15 (2), p.686-695

2007

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Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

Bioorganic & medicinal chemistry, 2008-11, Vol.18 (22), p.5879-5883

2008

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Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6265-6267

2008

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An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8 -tetrahydro -4H -pyrano [3,2 -c ]pyridine -3 -carbonitriles

Bioorganic & medicinal chemistry, 2007-12, Vol.17 (23), p.6459-6462

2007

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Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1840-1844

2008

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Synthesis and structure based optimization of novel Akt inhibitors

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3359-3363

2008

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Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1120-1123

2008

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Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction

Bioorganic & medicinal chemistry, 2017-11, Vol.25 (21), p.6007-6015

2017

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Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2342-2345

2008

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Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors

Discovery of novel pyridone-benzamide derivatives possessing a 1-methyl-2-benzimidazolinone moiety as potent EZH2 inhibitors for the treatment of B-cell lymphomas

A facile regioselective synthesis of novel spiro-thioxanthene and spiro-xanthene-9′,2-[1,3,4]thiadiazole derivatives as potential analgesic and anti-inflammatory agents

Discovery of harmiprims, harmine-primaquine hybrids, as potent and selective anticancer and antimalarial compounds

Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors

Thiophene containing triarylmethanes as antitubercular agents

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

Structure–activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes

Small molecule enabled chemical biology and drug discovery

Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

Discovery of indole-2-one derivatives as BRD4 (BD1) selective inhibitors

cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2- α]pyridine

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2- a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2- a]pyridines

Studies on the Importance of the 7α-, and 12α- hydroxyl groups of N-Aryl-3α,7α,12α-trihydroxy-5β-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile

Synthesis and evaluation of isosteres of N-methyl indolo[3,2- b]-quinoline (cryptolepine) as new antiinfective agents

Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide

Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis

An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8 -tetrahydro -4H -pyrano [3,2 -c ]pyridine -3 -carbonitriles

Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones

Synthesis and structure based optimization of novel Akt inhibitors

Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor

Synthesis of photocaged 6-O-(2-nitrobenzyl)guanosine and 4-O-(2-nitrobenzyl) uridine triphosphates for photocontrol of the RNA transcription reaction

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

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