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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Journal of molecular biology, 2020-11, Vol.432 (22), p.5849-5859

2020

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in cancer biology, 2022-05, Vol.80, p.1-17

2022

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Immunity (Cambridge, Mass.), 2021-05, Vol.54 (5), p.976-987.e7

2021

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Architecture and activation of phosphatidylinositol 3-kinase related kinases

Current opinion in structural biology, 2018-04, Vol.49, p.177-189

2018

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Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Cellular signalling, 2023-08, Vol.108, p.110693-110693, Article 110693

2023

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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein expression and purification, 2025-01, Vol.225, p.106582, Article 106582

2025

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Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway

Journal of ethnopharmacology, 2024-10, Vol.332, p.118366, Article 118366

2024

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Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

International journal of biological macromolecules, 2020-12, Vol.164, p.456-467

2020

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Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

Chemico-biological interactions, 2024-05, Vol.394, p.110968-110968, Article 110968

2024

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Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

Drug discovery today, 2015-08, Vol.20 (8), p.988-994

2015

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Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

Experimental gerontology, 2023-01, Vol.171, p.112028, Article 112028

2023

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PI3K/Akt signaling in osteosarcoma

Clinica chimica acta, 2015-04, Vol.444, p.182-192

2015

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Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Toxicology letters, 2015-09, Vol.237 (3), p.181-190

2015

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Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

European journal of vascular and endovascular surgery, 2020-08, Vol.60 (2), p.254-263

2020

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-06, Vol.36 (6), p.320-328

2011

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Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Molecular and cellular endocrinology, 2017-09, Vol.452, p.44-56

2017

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TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α

Cellular signalling, 2016-03, Vol.28 (3), p.148-156

2016

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Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase

Biochemical and biophysical research communications, 2011-07, Vol.410 (2), p.258-263

2011

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Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

The Journal of nutritional biochemistry, 2016-10, Vol.36, p.68-80

2016

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Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Biochemical pharmacology, 2014-08, Vol.90 (3), p.197-207

2014

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Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Journal of ethnopharmacology, 2022-05, Vol.289, p.115021, Article 115021

2022

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Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Carbohydrate polymers, 2020-12, Vol.249, p.116874-116874, Article 116874

2020

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Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains

Molecular immunology, 2021-03, Vol.131, p.51-59

2021

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Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

Cellular signalling, 2011-04, Vol.23 (4), p.603-608

Fung-Leung, Wai-Ping

2011

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Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Journal of molecular biology, 2021-04, Vol.433 (8), p.166838-166838, Article 166838

2021

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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

Architecture and activation of phosphatidylinositol 3-kinase related kinases

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway

Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

PI3K/Akt signaling in osteosarcoma

Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

TLR signalling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α

Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase

Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains

Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

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