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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein expression and purification, 2025-01, Vol.225, p.106582, Article 106582

2025

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The role of BTG2/PI3K/AKT pathway-mediated microglial activation in T-2 toxin-induced neurotoxicity

Toxicology letters, 2024-10, Vol.400, p.81-92

2024

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Discovery of Pyrazolo[1,5- a ]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors

Journal of medicinal chemistry, 2024-09, Vol.67 (17), p.15199-15219

2024

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Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature

Cancer Immunology, Immunotherapy : CII, 2024-08, Vol.73 (10), p.204, Article 204

2024

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Bisphenol S (BPS) induces glioblastoma progression via regulation of EZH2-mediated PI3K/AKT/mTOR pathway in U87-MG cells

Toxicology (Amsterdam), 2024-09, Vol.507, p.153898, Article 153898

2024

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Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway

Toxicology and applied pharmacology, 2024-09, Vol.490, p.117036, Article 117036

2024

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PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

JCI insight, 2024-07, Vol.9 (16)

2024

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Network Pharmacology Followed by Experimental Validation to Explore the Mechanism of Stigmasterol in Sangbaipi Decoction Regulating PI3K/Akt Signaling to Alleviate Acute Exacerbation of Chronic Obstructive Pulmonary Disease

International journal of chronic obstructive pulmonary disease, 2024-01, Vol.19, p.1819-1834

2024

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The Worsening of Myocardial Ischemia-Reperfusion Injury in Uremic Cardiomyopathy is Further Aggravated by PM 2.5 Exposure: Mitochondria Serve as the Central Focus of Pathology

Cardiovascular toxicology, 2024-11, Vol.24 (11), p.1236

2024

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Therapeutic potential of inhibiting the PI3Kγ complex for leukemia

Cell chemical biology, 2024-07, Vol.31 (7), p.1244

2024

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Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1429

2024

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Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): An integrated network toxicology and molecular docking strategy

Heliyon, 2024-09, Vol.10 (17), p.e37003, Article e37003

2024

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Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease

Experimental gerontology, 2024-10, Vol.196, p.112558, Article 112558

2024

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Germline mutations in a G protein identify signaling cross-talk in T cells

Science (American Association for the Advancement of Science), 2024-09, Vol.385 (6715), p.eadd8947

2024

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Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia

Proceedings of the National Academy of Sciences - PNAS, 2024-09, Vol.121 (39), p.e2319666121

2024

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Diosgenin Alleviates Obesity-Induced Insulin Resistance by Modulating PI3K/Akt Signaling Pathway in Mice Fed a High-Fat Diet

Chemical & pharmaceutical bulletin, 2024-10, Vol.72 (10), p.845-855, Article c24-00313

2024

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Integrative analysis of multi-omics data reveals importance of collagen and the PI3K AKT signalling pathway in CAKUT

Scientific reports, 2024-09, Vol.14 (1), p.20731-12, Article 20731

2024

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Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

Scientific reports, 2024-07, Vol.14 (1), p.17496-9, Article 17496

Sato, Koji

2024

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Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction

PloS one, 2024-09, Vol.19 (9), p.e0304485

2024

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SMYD5 methylation of rpL40 links ribosomal output to gastric cancer

Nature (London), 2024-08, Vol.632 (8025), p.656-663

2024

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Triiodothyronine (T3) promotes browning of white adipose through inhibition of the PI3K/AKT signalling pathway

Scientific reports, 2024-09, Vol.14 (1), p.20370-17, Article 20370

2024

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Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway

Cellular and molecular life sciences : CMLS, 2024-08, Vol.81 (1), p.360

2024

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Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

PloS one, 2024-07, Vol.19 (7), p.e0305927

2024

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The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway

Scientific reports, 2024-09, Vol.14 (1), p.21914-12, Article 21914

2024

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Microvascular and cellular dysfunctions in Alzheimer's disease: an integrative analysis perspective

Scientific reports, 2024-09, Vol.14 (1), p.20944-15, Article 20944

2024

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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

The role of BTG2/PI3K/AKT pathway-mediated microglial activation in T-2 toxin-induced neurotoxicity

Discovery of Pyrazolo[1,5- a ]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors

Targeting PI3K-gamma in myeloid driven tumour immune suppression: a systematic review and meta-analysis of the preclinical literature

Bisphenol S (BPS) induces glioblastoma progression via regulation of EZH2-mediated PI3K/AKT/mTOR pathway in U87-MG cells

Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway

PI3Kγ promotes neutrophil extracellular trap formation by noncanonical pyroptosis in abdominal aortic aneurysm

Network Pharmacology Followed by Experimental Validation to Explore the Mechanism of Stigmasterol in Sangbaipi Decoction Regulating PI3K/Akt Signaling to Alleviate Acute Exacerbation of Chronic Obstructive Pulmonary Disease

The Worsening of Myocardial Ischemia-Reperfusion Injury in Uremic Cardiomyopathy is Further Aggravated by PM 2.5 Exposure: Mitochondria Serve as the Central Focus of Pathology

Therapeutic potential of inhibiting the PI3Kγ complex for leukemia

Pericyte-to-Endothelial Cell Communication via Tunneling Nanotubes Is Disrupted by a Diol of Docosahexaenoic Acid

Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): An integrated network toxicology and molecular docking strategy

Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease

Germline mutations in a G protein identify signaling cross-talk in T cells

Hippo effector, Yorkie, is a tumor suppressor in select Drosophila squamous epithelia

Diosgenin Alleviates Obesity-Induced Insulin Resistance by Modulating PI3K/Akt Signaling Pathway in Mice Fed a High-Fat Diet

Integrative analysis of multi-omics data reveals importance of collagen and the PI3K AKT signalling pathway in CAKUT

Suppression of gp130 attenuated insulin-mediated signaling and glucose uptake in skeletal muscle cells

Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction

SMYD5 methylation of rpL40 links ribosomal output to gastric cancer

Triiodothyronine (T3) promotes browning of white adipose through inhibition of the PI3K/AKT signalling pathway

Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway

Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

The downregulation of SASH1 expression promotes breast cancer occurrence and invasion accompanied by the activation of PI3K-Akt-mTOR signaling pathway

Microvascular and cellular dysfunctions in Alzheimer's disease: an integrative analysis perspective

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