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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Journal of molecular biology, 2020-11, Vol.432 (22), p.5849-5859

2020

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Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Seminars in cancer biology, 2022-05, Vol.80, p.1-17

2022

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Architecture and activation of phosphatidylinositol 3-kinase related kinases

Current opinion in structural biology, 2018-04, Vol.49, p.177-189

2018

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Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Cellular signalling, 2023-08, Vol.108, p.110693-110693, Article 110693

2023

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Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Protein expression and purification, 2025-01, Vol.225, p.106582, Article 106582

2025

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Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

International journal of biological macromolecules, 2020-12, Vol.164, p.456-467

2020

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Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes

Environmental pollution (1987), 2018-03, Vol.234, p.406-419

2018

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Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

Drug discovery today, 2015-08, Vol.20 (8), p.988-994

2015

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Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

Experimental gerontology, 2023-01, Vol.171, p.112028, Article 112028

2023

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Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

European journal of vascular and endovascular surgery, 2020-08, Vol.60 (2), p.254-263

2020

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PI3K/Akt signaling in osteosarcoma

Clinica chimica acta, 2015-04, Vol.444, p.182-192

2015

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The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-06, Vol.36 (6), p.320-328

2011

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Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Molecular and cellular endocrinology, 2017-09, Vol.452, p.44-56

2017

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Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase

Biochemical and biophysical research communications, 2011-07, Vol.410 (2), p.258-263

2011

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Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

The Journal of nutritional biochemistry, 2016-10, Vol.36, p.68-80

2016

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Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Biochemical pharmacology, 2014-08, Vol.90 (3), p.197-207

2014

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Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Journal of ethnopharmacology, 2022-05, Vol.289, p.115021, Article 115021

2022

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Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains

Molecular immunology, 2021-03, Vol.131, p.51-59

2021

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Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Carbohydrate polymers, 2020-12, Vol.249, p.116874-116874, Article 116874

2020

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Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Journal of molecular biology, 2021-04, Vol.433 (8), p.166838-166838, Article 166838

2021

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Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae

Pharmacological research, 2020-06, Vol.156, p.104759, Article 104759

2020

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The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

Molecular immunology, 2018-02, Vol.94, p.7-17

2018

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Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation

Cellular signalling, 2018-10, Vol.50, p.111-120

2018

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Targeting PI3 kinase in cancer

Pharmacology & therapeutics (Oxford), 2015-02, Vol.146, p.53-60

2015

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Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor

Bioorganic & medicinal chemistry, 2015-04, Vol.23 (7), p.1386-1394

2015

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Structural Features that Distinguish Inactive and Active PI3K Lipid Kinases

Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy

Architecture and activation of phosphatidylinositol 3-kinase related kinases

Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer

Improved production of class I phosphatidylinositol 4,5-bisphosphate 3-kinase

Effects of chitosan and oligochitosans on the phosphatidylinositol 3-kinase-AKT pathway in cancer therapy

Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates phosphatidylinositol 3-kinase mediated DNA damage responses in lymphocytes

Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

Trigonelline, a plant derived alkaloid prevents ultraviolet-B-induced oxidative DNA damage in primary human dermal fibroblasts and BALB/c mice via modulation of phosphoinositide 3-kinase-Akt-Nrf2 signalling axis

Inhibition of Phosphatidylinositol 3-Kinase γ by IPI-549 Attenuates Abdominal Aortic Aneurysm Formation in Mice

PI3K/Akt signaling in osteosarcoma

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via phosphatidylinositol 3-kinase

Mulberry anthocyanin extract ameliorates insulin resistance by regulating PI3K/AKT pathway in HepG2 cells and db/db mice

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains

Structural characterization and immunomodulatory activity of a water-soluble polysaccharide from Ganoderma leucocontextum fruiting bodies

Biophysical and Structural Characterization of Novel RAS-Binding Domains (RBDs) of PI3Kα and PI3Kγ

Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae

The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation

Targeting PI3 kinase in cancer

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor

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