UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 284

Sortiert nach

Discovery of Novel Pyrrolo[2,3‑d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1243-1264

2022

Link zum Volltext

Verfügbarkeit prüfen

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

Journal of medicinal chemistry, 2018-04, Vol.61 (8), p.3478-3490

2018

Link zum Volltext

Verfügbarkeit prüfen

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7510-7528

2020

Link zum Volltext

Verfügbarkeit prüfen

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

Journal of medicinal chemistry, 2014-08, Vol.57 (16), p.6949-6964

2014

Link zum Volltext

Verfügbarkeit prüfen

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8754-8773

2018

Link zum Volltext

Verfügbarkeit prüfen

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.777-792

2023

Link zum Volltext

Verfügbarkeit prüfen

Discovery of a 9‑mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.2918-2927

2016

Link zum Volltext

Verfügbarkeit prüfen

Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo

Journal of medicinal chemistry, 2021-02, Vol.64 (4), p.2077-2109

2021

Link zum Volltext

Verfügbarkeit prüfen

Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3667-3683

2022

Link zum Volltext

Verfügbarkeit prüfen

Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.17572-17600

Cushman, Mark

2021

Link zum Volltext

Verfügbarkeit prüfen

Monohydrazone Based G‑Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.3090-3103

2020

Link zum Volltext

Verfügbarkeit prüfen

Structure-Based Design and Evaluation of Naphthalene Diimide G‑Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.2959-2974

2013

Link zum Volltext

Verfügbarkeit prüfen

Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3193-3217

2022

Link zum Volltext

Verfügbarkeit prüfen

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3306-3331

2022

Link zum Volltext

Verfügbarkeit prüfen

Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure-Activity Relationships of the Novel PPP4pT Series

Journal of medicinal chemistry, 2023-11, Vol.66 (22), p.15453-15476

2023

Link zum Volltext

Verfügbarkeit prüfen

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1584-1592

2021

Link zum Volltext

Verfügbarkeit prüfen

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7066-7083

2011

Link zum Volltext

Verfügbarkeit prüfen

Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X‑ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site

Journal of medicinal chemistry, 2023-03, Vol.66 (5), p.3588-3620

2023

Link zum Volltext

Verfügbarkeit prüfen

Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Partial Agonists: Design, Synthesis, Structure–Activity Relationship, and Anticancer Activities

Journal of medicinal chemistry, 2021-01, Vol.64 (2), p.1018-1036

2021

Link zum Volltext

Verfügbarkeit prüfen

Discovery of M‑808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4997-5010

2020

Link zum Volltext

Verfügbarkeit prüfen

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments

Journal of medicinal chemistry, 2024-01, Vol.67 (1), p.492-512

2024

Link zum Volltext

Verfügbarkeit prüfen

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.627-640

2023

Link zum Volltext

Verfügbarkeit prüfen

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Journal of medicinal chemistry, 2021-08, Vol.64 (16), p.12132-12151

2021

Link zum Volltext

Verfügbarkeit prüfen

Guaianolide Sesquiterpene Lactones, a Source To Discover Agents That Selectively Inhibit Acute Myelogenous Leukemia Stem and Progenitor Cells

Journal of medicinal chemistry, 2012-10, Vol.55 (20), p.8757-8769

2012

Link zum Volltext

Verfügbarkeit prüfen

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Journal of medicinal chemistry, 2020-12, Vol.63 (23), p.14609-14625

2020

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 284

Suche als RSS-Feed

Aktive Filter

ThemaAntineoplastic Agents - Chemistry

Zeitschrift / SerieJournal Of Medicinal Chemistry

ThemaAntineoplastic Agents - Pharmacology

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(284)
Mit Volltextzugriff
(284)

Publikationsform

Artikel
(284)

Sprache

Englisch
(284)
Japanisch
(66)
Russisch
(1)

Erscheinungsjahr

n.n

Thema

Drug Screening Assays, Antitumor
(280)
Chemistry, Medicinal
(269)
Life Sciences & Biomedicine
(269)
Pharmacology & Pharmacy
(269)
Science & Technology
(269)
Humans
(252)
Antineoplastic Agents - Chemical Synthesis
(247)
Structure-Activity Relationship
(201)
Cell Line, Tumor
(191)
Animals
(180)
Mice
(150)
Biological And Medical Sciences
(115)
Medical Sciences
(115)
Pharmacology. Drug Treatments
(113)
Antineoplastic Agents
(110)
General Aspects
(105)
Models, Molecular
(80)
Antineoplastic Agents - Pharmacokinetics
(77)
Female
(74)

14 weitere anzeigen...

Weniger anzeigen...

Kollektion

MEDLINE
(284)

Zeitschrift / Serie

J. Med. Chem
(3)

Menü

Weitere Dienste

Einstellungen

Discovery of Novel Pyrrolo[2,3‑d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

Discovery of a 9‑mer Cationic Peptide (LTX-315) as a Potential First in Class Oncolytic Peptide

Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo

Discovery of DNA-Targeting HDAC Inhibitors with Potent Antitumor Efficacy In Vivo That Trigger Antitumor Immunity

Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy

Monohydrazone Based G‑Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells

Structure-Based Design and Evaluation of Naphthalene Diimide G‑Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure-Activity Relationships of the Novel PPP4pT Series

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X‑ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site

Tetrazanbigen Derivatives as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Partial Agonists: Design, Synthesis, Structure–Activity Relationship, and Anticancer Activities

Discovery of M‑808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity

Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments

Discovery of Novel Acridane-Based Tubulin Polymerization Inhibitors with Anticancer and Potential Immunomodulatory Effects

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands

Guaianolide Sesquiterpene Lactones, a Source To Discover Agents That Selectively Inhibit Acute Myelogenous Leukemia Stem and Progenitor Cells

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Aktive Filter

Suchergebnisse filtern