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Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production

PloS one, 2014-03, Vol.9 (3), p.e90383-e90383

2014

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A fully human monoclonal antibody possesses antibody‐dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a conserved epitope at the HA1 protomer interface

Journal of medical virology, 2023-07, Vol.95 (7), p.e28901-n/a

2023

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No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model

PloS one, 2024-06, Vol.19 (6), p.e0290909

2024

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Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019

The Journal of infectious diseases, 2022-09, Vol.226 (4), p.655-663

2022

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Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Science translational medicine, 2016-02, Vol.8 (326), p.326ra21

2016

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Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Human vaccines & immunotherapeutics, 2022-04, Vol.18 (2), p.1940652

2022

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Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain

Journal of virology, 2020-10, Vol.94 (22)

2020

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Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source

mBio, 2024-09, p.e0160024

2024

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DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome

Science translational medicine, 2014-11, Vol.6 (264), p.264ra162

2014

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Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system

Scientific reports, 2019-01, Vol.9 (1), p.366-366, Article 366

2019

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Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy

Clinical infectious diseases, 2018-03, Vol.66 (7), p.1116-1119

2018

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Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models

Frontiers in microbiology, 2020-05, Vol.11, p.832-832

2020

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Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle

Scientific reports, 2016-04, Vol.6 (1), p.24897-24897, Article 24897

2016

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Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice

Antiviral research, 2017-10, Vol.146, p.164-173

2017

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Cloned transchromosomic calves producing human immunoglobulin

Nature biotechnology, 2002-09, Vol.20 (9), p.889-894

2002

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Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle

Nature genetics, 2004-07, Vol.36 (7), p.775-780

2004

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Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

iScience, 2023-10, Vol.26 (10), p.107764-107764, Article 107764

2023

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Cloned Calves from Chromatin Remodeled In Vitro

Biology of reproduction, 2004-01, Vol.70 (1), p.146-153

2004

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Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study

The Lancet infectious diseases, 2018-04, Vol.18 (4), p.410-418

2018

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Commercialising genetically engineered animal biomedical products

Reproduction fertility and development, 2008, Vol.20 (1), p.61

2008

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Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines

Scientific reports, 2020-05, Vol.10 (1), p.8764, Article 8764

2020

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Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus

Journal of virology, 2017-07, Vol.91 (14)

2017

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Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques

The Journal of infectious diseases, 2018-11, Vol.218 (suppl_5), p.S658-S661

2018

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Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models

Vaccine, 2017-07, Vol.35 (33), p.4079-4087

2017

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Cloned Calves from Chromatin Remodeled In Vitro1

Biology of reproduction, 2004-01, Vol.70 (1), p.146-153

2004

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Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production

A fully human monoclonal antibody possesses antibody‐dependent cellular cytotoxicity (ADCC) activity against the H1 subtype of influenza A virus by targeting a conserved epitope at the HA1 protomer interface

No evidence for enhanced disease with human polyclonal SARS-CoV-2 antibody in the ferret model

Increased Antibody Avidity and Cross-Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Variants by Hyperimmunized Transchromosomic Bovine–Derived Human Immunoglobulins for Treatment of Coronavirus Disease 2019

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head Domain

Preclinical evaluation of a fully human, quadrivalent-hantavirus polyclonal antibody derived from a non-human source

DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome

Generation of H7N9-specific human polyclonal antibodies from a transchromosomic goat (caprine) system

Deployment of Transchromosomal Bovine for Personalized Antimicrobial Therapy

Anti-HFRS Human IgG Produced in Transchromosomic Bovines Has Potent Hantavirus Neutralizing Activity and Is Protective in Animal Models

Production of Potent Fully Human Polyclonal Antibodies against Ebola Zaire Virus in Transchromosomal Cattle

Human polyclonal antibodies produced in transchromosomal cattle prevent lethal Zika virus infection and testicular atrophy in mice

Cloned transchromosomic calves producing human immunoglobulin

Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle

Transchromosomic bovine-derived anti-SARS-CoV-2 polyclonal human antibodies protects hACE2 transgenic hamsters against multiple variants

Cloned Calves from Chromatin Remodeled In Vitro

Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study

Commercialising genetically engineered animal biomedical products

Lipid Nanoparticle Formulation Increases Efficiency of DNA-Vectored Vaccines/Immunoprophylaxis in Animals Including Transchromosomic Bovines

Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus

Human Polyclonal Antibodies Produced by Transchromosomal Cattle Provide Partial Protection Against Lethal Zaire Ebolavirus Challenge in Rhesus Macaques

Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models

Cloned Calves from Chromatin Remodeled In Vitro1

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