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Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps

Nature communications, 2020-03, Vol.11 (1), p.1515-12, Article 1515

2020

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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

Nature communications, 2022-01, Vol.13 (1), p.74-74, Article 74

2022

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An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

Nature chemical biology, 2015-07, Vol.11 (7), p.465

2015

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Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability

American journal of human genetics, 2017-02, Vol.100 (2), p.257-266

2017

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Neuromelanin in Parkinson's Disease: Tyrosine Hydroxylase and Tyrosinase

International journal of molecular sciences, 2022-04, Vol.23 (8), p.4176

2022

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Disease duration and the integrity of the nigrostriatal system in Parkinson's disease

Brain (London, England : 1878), 2013-08, Vol.136 (Pt 8), p.2419-2431

2013

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Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

Nature medicine, 2011-12, Vol.17 (12), p.1657-1662

2011

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The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase

Archives of biochemistry and biophysics, 2023-02, Vol.735, p.109518-109518, Article 109518

Fitzpatrick, Paul F.

2023

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Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue

Biochemical and biophysical research communications, 2022-01, Vol.589, p.209-214

2022

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Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2020-03, Vol.183 (2), p.95-105

2020

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Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1

Journal of inherited metabolic disease, 2024-05, Vol.47 (3), p.517-532

2024

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Functional coculture of sympathetic neurons and cardiomyocytes derived from human-induced pluripotent stem cells

American journal of physiology. Heart and circulatory physiology, 2020-11, Vol.319 (5), p.H927-H937

2020

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Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon

Histology and histopathology, 2008-02, Vol.23 (2), p.197

2008

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MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

Schizophrenia research, 2010-12, Vol.124 (1), p.183-191

2010

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Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson disease

Neurology, 2017-04, Vol.88 (15), p.1461-1467

2017

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Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

Scientific reports, 2018-02, Vol.8 (1), p.2450-13, Article 2450

2018

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The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease

Journal of Neural Transmission, 2023-05, Vol.130 (5), p.611-625

2023

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Coumarin-Based Compounds as Inhibitors of Tyrosinase/Tyrosine Hydroxylase: Synthesis, Kinetic Studies, and In Silico Approaches

International journal of molecular sciences, 2023-03, Vol.24 (6), p.5216

2023

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Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans

PloS one, 2016-07, Vol.11 (7), p.e0158847-e0158847

2016

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Impact of proinflammatory epicardial adipose tissue and differentially enhanced autonomic remodeling on human atrial fibrillation

The Journal of thoracic and cardiovascular surgery, 2023-04, Vol.165 (4), p.e158-e174

2023

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Vitamin D signaling and the differentiation of developing dopamine systems

Neuroscience, 2016-10, Vol.333, p.193-203

2016

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Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease

Neurobiology of disease, 2019-10, Vol.130, p.104524, Article 104524

2019

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Mentalis nerve branches supplying the lower lip revisited: a study of human fetuses and donated elderly cadavers

Surgical and radiologic anatomy (English ed.), 2024-06, Vol.46 (6), p.895-904

2024

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Developing a highly efficient hydroxytyrosol whole-cell catalyst by de-bottlenecking rate-limiting steps

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability

Neuromelanin in Parkinson's Disease: Tyrosine Hydroxylase and Tyrosinase

Disease duration and the integrity of the nigrostriatal system in Parkinson's disease

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

The aromatic amino acid hydroxylases: Structures, catalysis, and regulation of phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase

Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue

Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis

Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1

Functional coculture of sympathetic neurons and cardiomyocytes derived from human-induced pluripotent stem cells

Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon

MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders

Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson disease

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson’s disease

Coumarin-Based Compounds as Inhibitors of Tyrosinase/Tyrosine Hydroxylase: Synthesis, Kinetic Studies, and In Silico Approaches

Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans

Impact of proinflammatory epicardial adipose tissue and differentially enhanced autonomic remodeling on human atrial fibrillation

Vitamin D signaling and the differentiation of developing dopamine systems

Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease

Mentalis nerve branches supplying the lower lip revisited: a study of human fetuses and donated elderly cadavers

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