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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

Cell reports (Cambridge), 2015-01, Vol.10 (3), p.383-397

2015

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Epigenetics and cancer

Genes & development, 2004-10, Vol.18 (19), p.2315-2335

2004

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BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

Molecular and Cellular Biology, 2011-05, Vol.31 (10), p.1972-1982

2011

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The many faces of ubiquitinated histone H2A: insights from the DUBs

Cell division, 2008-04, Vol.3 (1), p.8-8, Article 8

2008

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A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition

PloS one, 2020-04, Vol.15 (4), p.e0227592

2020

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Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy

International journal of molecular sciences, 2021-09, Vol.22 (17), p.9331

2021

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Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Breast cancer research : BCR, 2022-06, Vol.24 (1), p.1-41, Article 41

2022

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Association of BMI1 with Polycomb Bodies Is Dynamic and Requires PRC2/EZH2 and the Maintenance DNA Methyltransferase DNMT1

Molecular and Cellular Biology, 2005-12, Vol.25 (24), p.11047-11058

2005

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Stable X Chromosome Inactivation Involves the PRC1 Polycomb Complex and Requires Histone MACROH2A1 and the CULLIN3/SPOP Ubiquitin E3 Ligase

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (21), p.7635-7640

2005

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Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

Molecular and Cellular Biology, 2003-01, Vol.23 (1), p.389-401

2003

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EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

Breast cancer research : BCR, 2008-01, Vol.10 (6), p.R109-R109, Article R109

2008

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Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

Cancer cell, 2016-02, Vol.29 (2), p.241-241

2016

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Cancer genes hypermethylated in human embryonic stem cells

PloS one, 2008-09, Vol.3 (9), p.e3294-e3294

2008

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TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

The Journal of biological chemistry, 2002-02, Vol.277 (8), p.6567-6572

2002

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Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status

Journal of cell science, 1999-12, Vol.112 ( Pt 24) (24), p.4627-4639

1999

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Developmental biology Two paths to silence merge

Nature, 2006-02, Vol.439 (7078), p.794-795

2006

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Abstract SY35-01: Unexpected results of prolonged EZH2 inhibition in an in vivo model for glioblastoma

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.SY35-01-SY35-01

Lohuizen, Maarten van

2014

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Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

Molecular cell, 2003-08, Vol.12 (2), p.393-400

2003

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Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

Oncogene, 1997-08, Vol.15 (8), p.899-910

1997

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Abstract SY20-02: Role of Polycomb repressors in stem cells, cancer, DNA repair and iPS cell reprogramming

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.SY20-02-SY20-02

van Lohuizen, Maarten

2012

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Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells

Cancer gene therapy, 2024-04, Vol.31 (4), p.537-551

2024

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Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities

The Journal of experimental medicine, 2018-12, Vol.215 (12), p.3115-3135

2018

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Corrigendum: Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

Nature genetics, 2006-07, Vol.38 (7), p.850-850

2006

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The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

Genes & development, 2009-05, Vol.23 (10), p.1195-1206

2009

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USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

Cell reports (Cambridge), 2020-12, Vol.33 (13), p.108533-108533, Article 108533

2020

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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

Epigenetics and cancer

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

The many faces of ubiquitinated histone H2A: insights from the DUBs

A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition

Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Efficacy

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Association of BMI1 with Polycomb Bodies Is Dynamic and Requires PRC2/EZH2 and the Maintenance DNA Methyltransferase DNMT1

Stable X Chromosome Inactivation Involves the PRC1 Polycomb Complex and Requires Histone MACROH2A1 and the CULLIN3/SPOP Ubiquitin E3 Ligase

Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer

Cancer genes hypermethylated in human embryonic stem cells

TBX-3, the Gene Mutated in Ulnar-Mammary Syndrome, Is a Negative Regulator of p19 and Inhibits Senescence

Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status

Developmental biology Two paths to silence merge

Abstract SY35-01: Unexpected results of prolonged EZH2 inhibition in an in vivo model for glioblastoma

Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

Perturbation of B and T cell development and predisposition to lymphomagenesis in EμBmi1 transgenic mice require the Bmi1 RING finger

Abstract SY20-02: Role of Polycomb repressors in stem cells, cancer, DNA repair and iPS cell reprogramming

Retinoids and EZH2 inhibitors cooperate to orchestrate anti-oncogenic effects on bladder cancer cells

Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities

Corrigendum: Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

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