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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

PloS one, 2018-11, Vol.13 (11), p.e0206279-e0206279

2018

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In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Drug metabolism and disposition, 2003-08, Vol.31 (8), p.1005

2003

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Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.243

2005

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A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1616-1620

2014

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Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

Journal of the American Chemical Society, 2000-03, Vol.122 (12), p.2677-2686

2000

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A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2109-2121

2010

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Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5886-5887

1991

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Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Biochemistry (Easton), 1995-04, Vol.34 (13), p.4246-4256

1995

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Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9718-9719

1998

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Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

Biochemistry (Easton), 1997-04, Vol.36 (16), p.4895-4902

1997

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A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Rapid communications in mass spectrometry, 2015-11, Vol.29 (22), p.2175-2183

2015

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Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

Biochemical pharmacology, 2001-06, Vol.61 (12), p.1463-1470

2001

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The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Rapid communications in mass spectrometry, 2010-07, Vol.24 (14), p.2151-2161

2010

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Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

Chemico-biological interactions, 2005-06, Vol.155 (1), p.10-20

2005

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MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Biochimica et biophysica acta, 2005-04, Vol.1707 (2), p.157-169

2005

Volltextzugriff (PDF)

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

Journal of the American Chemical Society, 1991-11, Vol.113 (23), p.9009-9009

1991

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A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

Journal of organic chemistry, 1984-04, Vol.49 (7), p.1286-1288

1984

Volltextzugriff (PDF)

Peroxidative reactions of diversozymes 1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Peroxidative reactions of diversozymes1

The FASEB journal, 1996-03, Vol.10 (4), p.428-434

1996

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Evidence for a Role of a Perferryl-Oxygen Complex, FeO 3+ , in the N -Oxygenation of Amines by Cytochrome P450 Enzymes

Molecular pharmacology, 1997-01, Vol.51 (1), p.147-151

1997

Volltextzugriff (PDF)

Drug Metabolism: Significance and Challenges

Nuclear Receptors in Drug Metabolism, 2008, p.1-41

2008

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Radical intermediates in peroxide-dependent reactions catalyzed by cytochrome P-450

Journal of biosciences, 1987-03, Vol.11 (1-4), p.35-40

1987

Volltextzugriff (PDF)

Synthesis of β-3H-mitotane for use in a rapid assay for mitotane metabolism

Journal of labelled compounds & radiopharmaceuticals, 1995-02, Vol.36 (2), p.121-127

1995

Volltextzugriff (PDF)

Dehydroquinase catalyzed dehydration. II. Identification of the reactive conformation of the substrate responsible for syn elimination

Journal of the American Chemical Society, 1975-10, Vol.97 (20), p.5914-5915

1975

Volltextzugriff (PDF)

Radical intermediates in the catalytic cycles of cytochrome P-450

Basic life sciences, 1988, Vol.49, p.501

1988

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

Cytochrome P450-Catalyzed Hydroxylation of Mechanistic Probes that Distinguish between Radicals and Cations. Evidence for Cationic but Not for Radical Intermediates

A rapid and specific derivatization procedure to identify acyl-glucuronides by mass spectrometry

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide

Old yellow enzyme: Aromatization of cyclic enones and the mechanism of a novel dismutation reaction

Two Distinct Electrophilic Oxidants Effect Hydroxyl- ation in Cytochrome P-450-Catalyzed Reactions

Mechanism-Based Inactivation of Cytochrome P450 2B4 by Aldehydes: Relationship to Aldehyde Deformylation via a Peroxyhemiacetal Intermediate

A tag-free collisionally induced fragmentation approach to detect drug-adducted proteins by mass spectrometry: CID product ion tracking of protein-small molecule complexes

Azole-antifungal binding to a novel cytochrome P450 from Mycobacterium tuberculosis: implications for treatment of tuberculosis

The use of 18 O‐exchange and base‐catalyzed N ‐dealkylation with liquid chromatography/tandem mass spectrometry to identify carbinolamide metabolites

Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4

MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Olefin formation in the oxidative deformylation of aldehydes by cytochrome P-450. Mechanistic implications for catalysis by oxygen-derived peroxide [Erratum to document cited in CA115(5):48632c]

A convenient and simple method for the .alpha.'-chlorination of .alpha.,.beta. and conjugated ketones

Peroxidative reactions of diversozymes 1

Peroxidative reactions of diversozymes1

Evidence for a Role of a Perferryl-Oxygen Complex, FeO 3+ , in the N -Oxygenation of Amines by Cytochrome P450 Enzymes

Drug Metabolism: Significance and Challenges

Radical intermediates in peroxide-dependent reactions catalyzed by cytochrome P-450

Synthesis of β-3H-mitotane for use in a rapid assay for mitotane metabolism

Dehydroquinase catalyzed dehydration. II. Identification of the reactive conformation of the substrate responsible for syn elimination

Radical intermediates in the catalytic cycles of cytochrome P-450

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