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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections

Antimicrobial agents and chemotherapy, 2015-01, Vol.59 (1), p.289-298

2015

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Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Antimicrobial Agents and Chemotherapy, 2006-11, Vol.50 (11), p.3882-3885

2006

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Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin

Antimicrobial Agents and Chemotherapy, 2007-06, Vol.51 (6), p.2048-2052

2007

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Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4507-4509

2008

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A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential

Journal of microbiological methods, 2010-11, Vol.83 (2), p.254-256

2010

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In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains

Antimicrobial agents and chemotherapy, 2016-02, Vol.60 (2), p.729-734

2016

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Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2002-11, Vol.46 (11), p.3343-3347

2002

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In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

Journal of antimicrobial chemotherapy, 2016-03, Vol.71 (3), p.670-677

2016

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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2061-2065

2001

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Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

Antimicrobial Agents and Chemotherapy, 2003-06, Vol.47 (6), p.1784-1789

2003

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New benzylidenethiazolidinediones as antibacterial agents

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (21), p.3771-3773

2003

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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Antimicrobial Agents and Chemotherapy, 2002-06, Vol.46 (6), p.1880-1886

2002

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Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2241-2244

2001

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1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models

Open forum infectious diseases, 2019-10, Vol.6 (Supplement_2), p.S569-S569

2019

Volltextzugriff (PDF)

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Journal of visualized experiments, 2017-01 (119)

2017

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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1282-1292

2000

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248S-649266, a Novel Siderophore Cephalosporin: Efficacy against Klebsiella pneumoniae producing NDM-1 or KPC in rat lung infection model with recreated humanized exposure profile of 2 gram dose with 1 hour and 3 hours infusion

Open forum infectious diseases, 2014-12, Vol.1 (suppl_1), p.S106-S107

2014

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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3937-3941

2004

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In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

Journal of antimicrobial chemotherapy, 2000-04, Vol.45 (suppl-3), p.13-13

2000

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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.665-668

2003

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In vitro antibacterial activity of gemifloxacin and comparator compounds against common respiratory pathogens

Journal of antimicrobial chemotherapy, 2000-04, Vol.45 (suppl-3), p.23-23

2000

Volltextzugriff (PDF)

Postantibiotic and post-beta-lactamase inhibitor effects of amoxicillin plus clavulanate

Antimicrobial Agents and Chemotherapy, 1996-12, Vol.40 (12), p.2796-2801

1996

Volltextzugriff (PDF)

Information from your family doctor: Questions and answers about TB

American family physician, 2000-05, Vol.61 (9), p.2681

2000

Volltextzugriff (PDF)

Identification and management of tuberculosis

American family physician, 2000-05, Vol.61 (9), p.2667-2678

2000

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A survey of β-lactamase-producing Haemophilus influenzae an evaluation of 5750 isolates

Diagnostic microbiology and infectious disease, 1995-04, Vol.21 (4), p.223-225

1995

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Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections

Selection of Retapamulin, a Novel Pleuromutilin for Topical Use

Stepwise Exposure of Staphylococcus aureus to Pleuromutilins Is Associated with Stepwise Acquisition of Mutations in rplC and Minimally Affects Susceptibility to Retapamulin

Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential

In Vitro Antimicrobial Activity of a Siderophore Cephalosporin, S-649266, against Enterobacteriaceae Clinical Isolates, Including Carbapenem-Resistant Strains

Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus

In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)

Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

New benzylidenethiazolidinediones as antibacterial agents

Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4- b]indoles as potential antibacterial agents

1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

248S-649266, a Novel Siderophore Cephalosporin: Efficacy against Klebsiella pneumoniae producing NDM-1 or KPC in rat lung infection model with recreated humanized exposure profile of 2 gram dose with 1 hour and 3 hours infusion

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

In vitro activity of gemifloxacin against a broad range of recent clinical isolates from the USA

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

In vitro antibacterial activity of gemifloxacin and comparator compounds against common respiratory pathogens

Postantibiotic and post-beta-lactamase inhibitor effects of amoxicillin plus clavulanate

Information from your family doctor: Questions and answers about TB

Identification and management of tuberculosis

A survey of β-lactamase-producing Haemophilus influenzae an evaluation of 5750 isolates

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