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The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10616

Lugnier, Claire

2022

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The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure

Journal of clinical medicine, 2019-10, Vol.8 (10), p.1746

2019

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NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

Frontiers in pharmacology, 2020-08, Vol.11, p.1266-1266

2020

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NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues

American Journal of Physiology: Cell Physiology, 2011-10, Vol.301 (4), p.L441-L450

2011

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Modulation of VEGF-induced endothelial cell cycle protein expression through cyclic AMP hydrolysis by PDE2 and PDE4

Thrombosis and haemostasis, 2004-09, Vol.92 (3), p.634-645

2004

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Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Antioxidants, 2019-04, Vol.8 (4), p.93

2019

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Cyclic nucleotide phosphodiesterase (PDE) implication in lupus erythematosus: Effect of a new PDE4 inhibitor

Immunome research, 2017-01, Vol.13 (S1), p.44

Lugnier, Claire

2017

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New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6567-6572

2011

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Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition

European journal of pharmacology, 2010-07, Vol.638 (1-3), p.5-12

2010

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Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

British journal of pharmacology, 2012, Vol.165 (5), p.1288-1305

2012

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Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

Current drug discovery technologies, 2005-09, Vol.2 (3), p.161-167

2005

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Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

European journal of medicinal chemistry, 2019-09, Vol.177, p.269-290

2019

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Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Biochemical pharmacology, 2010-05, Vol.79 (9), p.1251-1260

2010

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Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation

Investigational new drugs, 2012-12, Vol.30 (6), p.2121-2131

2012

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Coupling of I1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline

Molecular pharmacology, 2000-06, Vol.57 (6), p.1142

2000

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Statins Therapy Improves Acute Ischemic Stroke in Patients with Cardio-metabolic Disorders Measured by Lipoprotein-Associated Phospholipase A2 (Lp-PLA2): New Focal Point

Neurology India, 2021-11, Vol.69 (6), p.1637-1644

2021

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Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

Cellular signalling, 2011, Vol.23 (1), p.152-160

2011

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COVID-19 and phosphodiesterase enzyme type 5 inhibitors

The journal of microscopy & ultrastructure, 2020-10, Vol.8 (4), p.141-145

2020

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Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52095-52105

2004

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Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52095-52105

2004

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NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production

Canadian journal of physiology and pharmacology, 2013-05, Vol.91 (5), p.353-361

2013

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Implication of cGMP cyclic nucleotide phosphodiesterases PDE1, PDE2 and PDE5 in early angiotensin II induced cardiac hypertrophy in rat

The FASEB journal, 2011-04, Vol.25 (S1), p.661.10-661.10

2011

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Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis

Cardiovascular research, 2003-08, Vol.59 (2), p.479-487

2003

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Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A 2 synthesis inhibition

European journal of pharmacology, 2010, Vol.638 (1), p.5-12

2010

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Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4

PloS one, 2012-01, Vol.7 (1), p.e28899

2012

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The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches

The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure

NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues

Modulation of VEGF-induced endothelial cell cycle protein expression through cyclic AMP hydrolysis by PDE2 and PDE4

Effect of the Phosphodiesterase 5 Inhibitor Sildenafil on Ischemia-Reperfusion-Induced Muscle Mitochondrial Dysfunction and Oxidative Stress

Cyclic nucleotide phosphodiesterase (PDE) implication in lupus erythematosus: Effect of a new PDE4 inhibitor

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

Reverse pharmacognosy: application of selnergy, a new tool for lead discovery. The example of epsilon-viniferin

Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation

Coupling of I1 Imidazoline Receptors to the cAMP Pathway: Studies with a Highly Selective Ligand, Benazoline

Statins Therapy Improves Acute Ischemic Stroke in Patients with Cardio-metabolic Disorders Measured by Lipoprotein-Associated Phospholipase A2 (Lp-PLA2): New Focal Point

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

COVID-19 and phosphodiesterase enzyme type 5 inhibitors

Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes

Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels

NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production

Implication of cGMP cyclic nucleotide phosphodiesterases PDE1, PDE2 and PDE5 in early angiotensin II induced cardiac hypertrophy in rat

Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis

Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A 2 synthesis inhibition

Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4

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