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The significance of G protein-coupled receptor crystallography for drug discovery

Pharmacological reviews, 2011-12, Vol.63 (4), p.901-937

2011

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Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF

Frontiers in physiology, 2020-06, Vol.11, p.728-728

2020

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Activation of G Protein-Coupled Receptors : Beyond Two-State Models and Tertiary Conformational Changes

Annual review of pharmacology and toxicology, 2008-01, Vol.48 (1), p.107-141

2008

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Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

The Journal of biological chemistry, 2012-07, Vol.287 (28), p.23790-23807

2012

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Protein Footprinting: Auxiliary Engine to Power the Structural Biology Revolution

Journal of molecular biology, 2020-04, Vol.432 (9), p.2973-2984

2020

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The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation

Structure (London), 2015-12, Vol.23 (12), p.2358-2364

2015

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A multipronged footprinting map validates the predicted structure of stress biomarker Neuropeptide Y (NPY) and its binding with novel peptide binders

Biophysical journal, 2023-02, Vol.122 (3), p.472a-472a

2023

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Evaluating Mass Spectrometry-Based Hydroxyl Radical Protein Footprinting of a Benchtop Flash Oxidation System against a Synchrotron X‑ray Beamline

Journal of the American Society for Mass Spectrometry, 2024-03, Vol.35 (3), p.476-486

2024

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New high‐throughput endstation to accelerate the experimental optimization pipeline for synchrotron X‐ray footprinting

Journal of synchrotron radiation, 2021-09, Vol.28 (5), p.1321-1332

2021

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The Role of Gβγ and Domain Interfaces in the Activation of G Protein-Coupled Receptor Kinase 2

Biochemistry (Easton), 2005-05, Vol.44 (18), p.6958-6970

2005

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Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1271, p.123

2015

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Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization

Journal of structural biology, 2011-12, Vol.176 (3), p.387-394

2011

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Keeping G Proteins at Bay: A Complex between G Protein-Coupled Receptor Kinase 2 and Gβγ

Science (American Association for the Advancement of Science), 2003-05, Vol.300 (5623), p.1256-1262

2003

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Conformational flexibility in the catalytic triad revealed by the high-resolution crystal structure of Streptomyces erythraeus trypsin in an unliganded state

Acta crystallographica. Section D, Biological crystallography., 2014-03, Vol.70 (3), p.833-840

2014

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Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1867-1870

2010

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Structure of the Full-Length TRPV2 Channel by Cryo-EM

Microscopy and microanalysis, 2016-07, Vol.22 (S3), p.1118-1119

2016

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Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: Biochemical and clinical evaluations

Vision research (Oxford), 2007-07, Vol.47 (15), p.2055-2066

2007

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Elucidating lactate oxidase enzyme–biomarker lactate interactions by SAXS, crystallography and X-ray footprinting for developing a real-time stress biosensor

Acta crystallographica. Section A, Foundations and advances, 2021-07, Vol.77 (a1), p.a49-a49

2021

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Reprint of “Crystal packing analysis of Rhodopsin crystals” [J. Struct. Biol. 158 (2007) 455–462]

Journal of structural biology, 2007-08, Vol.159 (2), p.253-260

2007

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Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions

Acta crystallographica. Section F, Structural biology and crystallization communications, 2007-06, Vol.63 (6), p.457-461

2007

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Molecular Dynamics Insights into TRPV5 Channel Inhibition by Small Molecules

Biophysical journal, 2018-02, Vol.114 (3), p.485a-486a

2018

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The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation

Structure (London), 2015-12, Vol.23 (12)

2015

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An ELIC-GLIC Chimera Reveals Distinct Pathways of Activation in the Cys-Loop Family of Receptors

Biophysical journal, 2015-01, Vol.108 (2), p.192a-192a

2015

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Structural Insights into Ligand Modulation of the TRPV2 Channel

Biophysical journal, 2019-02, Vol.116 (3), p.451a-451a

2019

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Assembly of a GPCR-G Protein Complex

Cell, 2019-05, Vol.177 (5)

2019

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The significance of G protein-coupled receptor crystallography for drug discovery

Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF

Activation of G Protein-Coupled Receptors : Beyond Two-State Models and Tertiary Conformational Changes

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

Protein Footprinting: Auxiliary Engine to Power the Structural Biology Revolution

The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation

A multipronged footprinting map validates the predicted structure of stress biomarker Neuropeptide Y (NPY) and its binding with novel peptide binders

Evaluating Mass Spectrometry-Based Hydroxyl Radical Protein Footprinting of a Benchtop Flash Oxidation System against a Synchrotron X‑ray Beamline

New high‐throughput endstation to accelerate the experimental optimization pipeline for synchrotron X‐ray footprinting

The Role of Gβγ and Domain Interfaces in the Activation of G Protein-Coupled Receptor Kinase 2

Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange

Rhodopsin–transducin heteropentamer: Three-dimensional structure and biochemical characterization

Keeping G Proteins at Bay: A Complex between G Protein-Coupled Receptor Kinase 2 and Gβγ

Conformational flexibility in the catalytic triad revealed by the high-resolution crystal structure of Streptomyces erythraeus trypsin in an unliganded state

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

Structure of the Full-Length TRPV2 Channel by Cryo-EM

Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: Biochemical and clinical evaluations

Elucidating lactate oxidase enzyme–biomarker lactate interactions by SAXS, crystallography and X-ray footprinting for developing a real-time stress biosensor

Reprint of “Crystal packing analysis of Rhodopsin crystals” [J. Struct. Biol. 158 (2007) 455–462]

Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions

Molecular Dynamics Insights into TRPV5 Channel Inhibition by Small Molecules

The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation

An ELIC-GLIC Chimera Reveals Distinct Pathways of Activation in the Cys-Loop Family of Receptors

Structural Insights into Ligand Modulation of the TRPV2 Channel

Assembly of a GPCR-G Protein Complex

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