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Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

ACS chemical neuroscience, 2019-01, Vol.10 (1), p.358-370

2019

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The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

Physiological reports, 2019-12, Vol.7 (23), p.e14303-n/a

2019

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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (4), p.e2212338120-e2212338120

2023

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Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590

Molecular pharmacology, 2017-09, Vol.92 (3), p.338-346

2017

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The Shifting Landscape of K Atp Channelopathies and the Need for ‘Sharper’ Therapeutics

Future medicinal chemistry, 2016-05, Vol.8 (7), p.789-802

2016

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Plight of the pore polar bar(rier)

Channels (Austin, Tex.), 2017-11, Vol.11 (6), p.502-503

2017

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Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

Evidence-based complementary and alternative medicine, 2015-01, Vol.2015, p.148791-9

2015

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Discovery and in Vitro Optimization of 3‑Sulfamoylbenzamides as ROMK Inhibitors

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.125-130

2018

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Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence

FEBS letters, 2005-12, Vol.579 (30), p.6809-6813

2005

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Development of novel therapeutics for treating edema and SeSAME/EAST syndrome targeting heteromeric Kir4.1/5.1 potassium channels

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Development of Distal Nephron Diuretics Targeting Heteromeric Kir4.1/5.1 Potassium Channels

The FASEB journal, 2019-04, Vol.33 (S1), p.824.2-824.2

2019

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BK channels in rat and human pulmonary smooth muscle cells are BKα-β 1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert

Pulmonary circulation, 2016-12, Vol.6 (4), p.563-575

2016

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VU590 inhibits Kir1.1 and Kir7.1 potassium channels through distinct molecular mechanisms

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Development of cell‐based high‐throughput screening assay for DNase I inhibitors or activators

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Discovery, characterization, and preclinical development of a Kir4.1 (KCNJ10) inhibitor for the treatment of hypertension

The FASEB journal, 2018-04, Vol.32 (S1), p.829.8-829.8

2018

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ROMK Inhibitor Actions in the Nephron Probed with Diuretics

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Kir4.1 ( KCNJ10 ) Inhibition with a Newly Developed Antagonist Induces Diuresis in Rats

The FASEB journal, 2016-04, Vol.30 (S1)

2016

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Discovery and characterization of a novel class of phenylsulfonylpiperazine containing compounds as inhibitors of the Aedes aegypti Kir1 (AeKir1) potassium channel

The FASEB journal, 2019-04, Vol.33 (S1), p.862.8-862.8

2019

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Effect of β3 subunit deletion on L‐type calcium channels in mouse small mesenteric arteries

The FASEB journal, 2010-04, Vol.24 (S1), p.576.2-576.2

2010

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α1‐Adrenergic receptor (α1‐AR) activation rapidly upregulates L‐type Ca2+ channels in rat mesenteric arteries in vivo

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Targeting the high‐conductance Ca2+‐activated K+ (BK) channel as vasodilator therapy for pulmonary hypertension

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Dynamic turnover of L‐type calcium channels in rat mesenteric arteries in vivo

The FASEB journal, 2012-04, Vol.26 (S1)

2012

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L‐type Ca2+ (CaL) Channels are Silent During Depolarization of Venous Smooth Muscle

The FASEB journal, 2010-04, Vol.24, p.576.1-576.1

2010

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L‐type Ca 2+ (Ca L ) Channels are Silent During Depolarization of Venous Smooth Muscle

The FASEB journal, 2010-04, Vol.24 (S1)

2010

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Upregulation of vascular L‐type calcium channels during hypertension is blunted in the absence of accessory β3 subunits

The FASEB journal, 2011-04, Vol.25, p.808.6-808.6

2011

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Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590

The Shifting Landscape of K Atp Channelopathies and the Need for ‘Sharper’ Therapeutics

Plight of the pore polar bar(rier)

Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

Discovery and in Vitro Optimization of 3‑Sulfamoylbenzamides as ROMK Inhibitors

Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence

Development of novel therapeutics for treating edema and SeSAME/EAST syndrome targeting heteromeric Kir4.1/5.1 potassium channels

Development of Distal Nephron Diuretics Targeting Heteromeric Kir4.1/5.1 Potassium Channels

BK channels in rat and human pulmonary smooth muscle cells are BKα-β 1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert

VU590 inhibits Kir1.1 and Kir7.1 potassium channels through distinct molecular mechanisms

Development of cell‐based high‐throughput screening assay for DNase I inhibitors or activators

Discovery, characterization, and preclinical development of a Kir4.1 (KCNJ10) inhibitor for the treatment of hypertension

ROMK Inhibitor Actions in the Nephron Probed with Diuretics

Kir4.1 ( KCNJ10 ) Inhibition with a Newly Developed Antagonist Induces Diuresis in Rats

Discovery and characterization of a novel class of phenylsulfonylpiperazine containing compounds as inhibitors of the Aedes aegypti Kir1 (AeKir1) potassium channel

Effect of β3 subunit deletion on L‐type calcium channels in mouse small mesenteric arteries

α1‐Adrenergic receptor (α1‐AR) activation rapidly upregulates L‐type Ca2+ channels in rat mesenteric arteries in vivo

Targeting the high‐conductance Ca2+‐activated K+ (BK) channel as vasodilator therapy for pulmonary hypertension

Dynamic turnover of L‐type calcium channels in rat mesenteric arteries in vivo

L‐type Ca2+ (CaL) Channels are Silent During Depolarization of Venous Smooth Muscle

L‐type Ca 2+ (Ca L ) Channels are Silent During Depolarization of Venous Smooth Muscle

Upregulation of vascular L‐type calcium channels during hypertension is blunted in the absence of accessory β3 subunits

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