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Methyltransferases of gentamicin biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (6), p.1340-1345

2018

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Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin

ACS chemical biology, 2019-05, Vol.14 (5), p.925-933

2019

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Structural Basis of the Selectivity of GenN, an Aminoglycoside N‑Methyltransferase Involved in Gentamicin Biosynthesis

ACS chemical biology, 2017-11, Vol.12 (11), p.2779-2787

2017

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Crystal structure and mechanism of a bacterial fluorinating enzyme

Nature, 2004-02, Vol.427 (6974), p.561-565

2004

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Spectroscopic and Electronic Structure Studies of Aromatic Electrophilic Attack and Hydrogen-Atom Abstraction by Non-Heme Iron Enzymes

Proceedings of the National Academy of Sciences - PNAS, 2006-08, Vol.103 (35), p.12966-12973

2006

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Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin

Chembiochem : a European journal of chemical biology, 2007-02, Vol.8 (3), p.283-288

2007

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Characterization of the Enzyme BtrD from Bacillus circulans and Revision of Its Functional Assignment in the Biosynthesis of Butirosin

Angewandte Chemie International Edition, 2007-01, Vol.46 (9), p.1462-1464

2007

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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase

Organic & biomolecular chemistry, 2008-09, Vol.6 (18), p.3306-3314

2008

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Efophylins A and B, Two C2-Asymmetric Macrodiolide Immunosuppressants from Streptomyces malaysiensis

Journal of natural products (Washington, D.C.), 2021-05, Vol.84 (5), p.1579-1586

2021

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Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

Proteins, structure, function, and bioinformatics, 2006-10, Vol.65 (1), p.220-230

2006

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Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis

ACS catalysis, 2021-10, Vol.11 (19), p.12274-12283

2021

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Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis

ACS chemical biology, 2024-09, Vol.19 (9), p.2002-2011

2024

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Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes

Angewandte Chemie International Edition, 2016-03, Vol.55 (10), p.3463-3467

International ed. in English, 2016

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Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

Chemistry & biology, 2015-02, Vol.22 (2), p.251-261

2015

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Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

Chemistry & biology, 2014-05, Vol.21 (5), p.608-618

2014

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Characterization of the Enzyme BtrD from Bacillus circulans and Revision of Its Functional Assignment in the Biosynthesis of Butirosin

Angewandte Chemie, 2007-02, Vol.119 (9), p.1484-1486

2007

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The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine

Organic & biomolecular chemistry, 2005-04, Vol.3 (8), p.1410-1418

2005

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Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

The Journal of biological chemistry, 2010-07, Vol.285 (29), p.22495-22504

2010

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Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution

FEBS letters, 2006-06, Vol.580 (14), p.3445-3450

2006

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Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes

Angewandte Chemie, 2016-03, Vol.128 (10), p.3524-3528

2016

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Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

Chemical communications (Cambridge, England), 2002-12 (23), p.2860-2861

2002

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The Gene Cluster for Fluorometabolite Biosynthesis in Streptomyces cattleya: A Thioesterase Confers Resistance to Fluoroacetyl-Coenzyme A

Chemistry & biology, 2006-05, Vol.13 (5), p.475-484

2006

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Biosynthesis of the Unique Amino Acid Side Chain of Butirosin: Possible Protective-Group Chemistry in an Acyl Carrier Protein-Mediated Pathway

Chemistry & biology, 2005-06, Vol.12 (6), p.665-675

2005

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Crystal sbucture and mechanism of a bacterial fluorinating enzyme

Nature (London), 2004, Vol.427 (6974), p.561-565

2004

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Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamineElectronic supplementary information (ESI) available: LC-MS, TLC and ESI-Q-TOF MS. See http://www.rsc.org/suppdata/cc/b2/b209799k

Chemical communications (Cambridge, England), 2002-11 (23), p.2860-2861

2002

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Methyltransferases of gentamicin biosynthesis

Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in the Biosynthesis of Gentamicin

Structural Basis of the Selectivity of GenN, an Aminoglycoside N‑Methyltransferase Involved in Gentamicin Biosynthesis

Crystal structure and mechanism of a bacterial fluorinating enzyme

Spectroscopic and Electronic Structure Studies of Aromatic Electrophilic Attack and Hydrogen-Atom Abstraction by Non-Heme Iron Enzymes

Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin

Characterization of the Enzyme BtrD from Bacillus circulans and Revision of Its Functional Assignment in the Biosynthesis of Butirosin

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase

Efophylins A and B, Two C2-Asymmetric Macrodiolide Immunosuppressants from Streptomyces malaysiensis

Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis

Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis

Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes

Delineating the Biosynthesis of Gentamicin X2, the Common Precursor of the Gentamicin C Antibiotic Complex

Specificity and Promiscuity at the Branch Point in Gentamicin Biosynthesis

Characterization of the Enzyme BtrD from Bacillus circulans and Revision of Its Functional Assignment in the Biosynthesis of Butirosin

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution

Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine

The Gene Cluster for Fluorometabolite Biosynthesis in Streptomyces cattleya: A Thioesterase Confers Resistance to Fluoroacetyl-Coenzyme A

Biosynthesis of the Unique Amino Acid Side Chain of Butirosin: Possible Protective-Group Chemistry in an Acyl Carrier Protein-Mediated Pathway

Crystal sbucture and mechanism of a bacterial fluorinating enzyme

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamineElectronic supplementary information (ESI) available: LC-MS, TLC and ESI-Q-TOF MS. See http://www.rsc.org/suppdata/cc/b2/b209799k

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