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Central and Peripheral Inflammation in Mild Cognitive Impairment in the Context of Alzheimer's Disease

International journal of molecular sciences, 2023-06, Vol.24 (13), p.10523

2023

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Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers

NeuroImage (Orlando, Fla.), 2021-04, Vol.230, p.117785-117785, Article 117785

2021

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In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB

Journal of cerebral blood flow and metabolism, 2017-08, Vol.37 (8), p.2716-2727

2017

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Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Journal of neuroinflammation, 2016-08, Vol.13 (1), p.189-189, Article 189

2016

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Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

Biological psychiatry : cognitive neuroscience and neuroimaging, 2017-07, Vol.2 (5), p.449-456

2017

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Metabotropic Glutamate Receptors for Parkinson's Disease Therapy

Parkinson's disease, 2013-01, Vol.2013 (2013), p.1-11

2013

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Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

Trends in pharmacological sciences (Regular ed.), 2001-07, Vol.22 (7), p.331-337

2001

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Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

Clinical epigenetics, 2016-02, Vol.8 (15), p.15-15, Article 15

2016

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The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

BMC medical genetics, 2012-03, Vol.13 (1), p.13-13, Article 13

2012

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Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

European journal of pharmacology, 2000-10, Vol.406 (3), p.403-410

2000

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VHB937, a TREM2 Stabilizing and Activating Antibody Strongly Reduces Pathology After Peripheral Administration in a Broad Range of Animal Models for Neuroinflammation and Neurodegeneration (P4-4.004)

Neurology, 2024-04, Vol.102 (17_supplement_1)

2024

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Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers

European journal of nuclear medicine and molecular imaging, 2008-04, Vol.35 (4), p.766-770

2008

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THE CMS MUON DETECTOR: FROM THE FIRST THOUGHTS TO THE FINAL DESIGN

International journal of modern physics. A, Particles and fields, gravitation, cosmology, 2010-06, Vol.25 (16), p.3121-3154

GASPARINI, FABRIZIO

2010

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Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056

Science translational medicine, 2011-01, Vol.3 (64), p.64ra1

2011

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Protein synthesis levels are increased in a subset of individuals with fragile X syndrome

Human molecular genetics, 2018-06, Vol.27 (12), p.2039-2051

2018

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AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials

Movement disorders, 2011-06, Vol.26 (7), p.1243-1250

2011

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A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease

Movement disorders, 2015-03, Vol.30 (3), p.427-431

2015

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Protein synthesis levels are increased in a subset of individuals with fragile X syndrome

Human molecular genetics, 2018-11, Vol.27 (21), p.3825-3825

2018

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Optically Pure 7-Oxabicyclo[2.2.1]hept-5-en-2-yl Derivatives ("Naked Sugars") as New Chirons

Synlett, 1990, Vol.1990 (4), p.173-185

1990

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Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study

Advances in therapy, 2017-02, Vol.34 (2), p.524-541

2017

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Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11C]ABP688 PET imaging

Synapse (New York, N.Y.), 2014-12, Vol.68 (12), p.565-573

2014

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Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

Chimia, 2004-03, Vol.58 (3), p.133

2004

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Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington’s disease: a preliminary investigation in the postmortem human brain

Brain Structure and Function, 2015-09, Vol.220 (5), p.3043-3051

2015

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Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with 11 CABP688 PET imaging

Synapse (New York, N.Y.), 2014-12, Vol.68 (12), p.565

2014

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Allosteric Modulators for mGlu Receptors

Current neuropharmacology, 2007-09, Vol.5 (3), p.187-194

2007

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Central and Peripheral Inflammation in Mild Cognitive Impairment in the Context of Alzheimer's Disease

Regional brain mGlu5 receptor occupancy following single oral doses of mavoglurant as measured by [11C]-ABP688 PET imaging in healthy volunteers

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

Metabotropic Glutamate Receptors for Parkinson's Disease Therapy

Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Effects of the prototypical mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

VHB937, a TREM2 Stabilizing and Activating Antibody Strongly Reduces Pathology After Peripheral Administration in a Broad Range of Animal Models for Neuroinflammation and Neurodegeneration (P4-4.004)

Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers

THE CMS MUON DETECTOR: FROM THE FIRST THOUGHTS TO THE FINAL DESIGN

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056

Protein synthesis levels are increased in a subset of individuals with fragile X syndrome

AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials

A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington's disease

Protein synthesis levels are increased in a subset of individuals with fragile X syndrome

Optically Pure 7-Oxabicyclo[2.2.1]hept-5-en-2-yl Derivatives ("Naked Sugars") as New Chirons

Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study

Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11C]ABP688 PET imaging

Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington’s disease: a preliminary investigation in the postmortem human brain

Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with 11 CABP688 PET imaging

Allosteric Modulators for mGlu Receptors

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