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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Journal of molecular biology, 2019-05, Vol.431 (11), p.2143-2162

2019

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Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

European journal of medicinal chemistry, 2020-03, Vol.189, p.112043, Article 112043

2020

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Alternative Thiol-Based Redox Systems

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.407-409

2018

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Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Biochemical and biophysical research communications, 2022-12, Vol.637, p.308-313

2022

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Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

European journal of organic chemistry, 2022-09, Vol.2022 (34), p.n/a

2022

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

PloS one, 2023-11, Vol.18 (11), p.e0292946-e0292946

2023

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.358

2021

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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004617-e0004617

2016

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Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.463-486

2018

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Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules (Basel, Switzerland), 2016-03, Vol.21 (3), p.368

2016

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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.912-929

2022

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In vitro activity and mode of action of distamycin analogues against African trypanosomes

European journal of medicinal chemistry, 2017-01, Vol.126, p.776-788

2017

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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

European journal of medicinal chemistry, 2023-01, Vol.246, p.114926-114926, Article 114926

2023

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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International journal for parasitology -- drugs and drug resistance, 2024-04, Vol.24, p.100529-100529, Article 100529

2024

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Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Analytical biochemistry, 2013-04, Vol.435 (1), p.74-82

2013

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Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

Redox biology, 2021-10, Vol.46, p.102085-102085, Article 102085

2021

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The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

Scientific reports, 2018-09, Vol.8 (1), p.13716-14, Article 13716

2018

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Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

International journal for parasitology -- drugs and drug resistance, 2017-12, Vol.7 (3), p.303-313

2017

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Ensemble learning application to discover new trypanothione synthetase inhibitors

Molecular diversity, 2021-08, Vol.25 (3), p.1361-1373

2021

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Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of enzyme inhibition and medicinal chemistry, 2020-12, Vol.35 (1), p.1345-1358

2020

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Evaluation of the Anti- Leishmania mexicana and - Trypanosoma brucei Activity and Mode of Action of 4,4'-(Arylmethylene)bis(3-methyl-1-phenyl-1 H -pyrazol-5-ol)

Biomedicines, 2022-08, Vol.10 (8), p.1913

2022

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CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones

Frontiers in molecular biosciences, 2021-03, Vol.8, p.629773-629773

2021

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The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

iScience, 2020-05, Vol.23 (5), p.101097-101097, Article 101097

2020

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Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

EBioMedicine, 2021-01, Vol.63, p.103206-103206, Article 103206

2021

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Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis

Proteomics (Weinheim), 2007-09, Vol.7 (18), p.3332-3341

2007

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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Alternative Thiol-Based Redox Systems

Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

In vitro activity and mode of action of distamycin analogues against African trypanosomes

Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

Ensemble learning application to discover new trypanothione synthetase inhibitors

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Evaluation of the Anti- Leishmania mexicana and - Trypanosoma brucei Activity and Mode of Action of 4,4'-(Arylmethylene)bis(3-methyl-1-phenyl-1 H -pyrazol-5-ol)

CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones

The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system

Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis

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