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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

The Journal of physiology, 2020-05, Vol.598 (9), p.1683-1693

Colecraft, Henry M.

2020

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Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Nature (London), 2020-01, Vol.577 (7792), p.695-700

2020

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Structure and selectivity in bestrophin ion channels

Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6207), p.355-359

2014

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Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

PloS one, 2012-05, Vol.7 (5), p.e37079-e37079

2012

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Structural mechanism of ligand activation in human calcium-sensing receptor

eLife, 2016-07, Vol.5 (2016)

2016

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A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

eLife, 2019-08, Vol.8

2019

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Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18213-18218

2014

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Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Nature communications, 2022-12, Vol.13 (1), p.7556-7556, Article 7556

2022

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Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Circulation (New York, N.Y.), 2018-10, Vol.138 (14), p.1431-1445

2018

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Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

eLife, 2023-08, Vol.12

2023

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Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Frontiers in physiology, 2018-04, Vol.9, p.397-397

2018

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Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Molecular therapy. Nucleic acids, 2023-12, Vol.34, p.102032, Article 102032

2023

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Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

Cell death & disease, 2023-04, Vol.14 (4), p.297-297, Article 297

2023

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Ion channels: channel production and optical methods

2021

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Ion channels: channel chemical biology, engineering, and physiological function

2021

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Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Frontiers in physiology, 2022-11, Vol.13, p.902224-902224

2022

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Research Highlights: Biophysics of Calcium

Biophysical journal, 2020-10, Vol.119 (8), p.1472-1473

Colecraft, Henry M.

2020

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Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15461-15466

2013

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David T. Yue: In Memoriam

Neuron (Cambridge, Mass.), 2015-03, Vol.85 (6), p.1158-1161

2015

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Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

PloS one, 2017-03, Vol.12 (3), p.e0174525-e0174525

2017

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Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

Nature methods, 2020-12, Vol.17 (12), p.1245-1253

2020

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Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

eLife, 2017-01, Vol.6

2017

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Controlling ion channel function with renewable recombinant antibodies

The Journal of physiology, 2022-05, Vol.600 (9), p.2023-2036

2022

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Regulation of microdomain voltage-gated L-type calcium channels in cardiac health and disease

Current opinion in physiology, 2018-04, Vol.2, p.13-18

2018

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Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels

The Journal of physiology, 2011-09, Vol.589 (18), p.4437-4455

2011

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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

Structure and selectivity in bestrophin ion channels

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

Structural mechanism of ligand activation in human calcium-sensing receptor

A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits

Preassociated apocalmodulin mediates Ca²⁺-dependent sensitization of activation and inactivation of TMEM16A/16B Ca²⁺-gated Cl⁻ channels

Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

Ion channels: channel production and optical methods

Ion channels: channel chemical biology, engineering, and physiological function

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Research Highlights: Biophysics of Calcium

Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing

David T. Yue: In Memoriam

Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies

Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels

Controlling ion channel function with renewable recombinant antibodies

Regulation of microdomain voltage-gated L-type calcium channels in cardiac health and disease

Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels

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