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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

ACS medicinal chemistry letters, 2015-06, Vol.6 (6), p.630-634

2015

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Syk tyrosine kinase required for mouse viability and B-cell development

Nature (London), 1995-11, Vol.378 (6554), p.303-306

1995

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Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase

Oncogene, 1999-02, Vol.18 (6), p.1261-1266

1999

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Membrane Glycoprotein IV (CD36) is Physically Associated with the Fyn, Lyn, and Yes Protein-Tyrosine Kinases in Human Platelets

Proceedings of the National Academy of Sciences - PNAS, 1991-09, Vol.88 (17), p.7844-7848

1991

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Transcriptional analysis of the PTEN/MMAC1 pseudogene, ΨPTEN

Oncogene, 1999-03, Vol.18 (9), p.1765-1769

1999

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Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils (∗)

The Journal of biological chemistry, 1996-01, Vol.271 (3), p.1455-1461

1996

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Blood, 2010-09, Vol.116 (9), p.1515-1523

2010

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Signal Transduction through the CD4 Receptor Involves the Activation of the Internal Membrane Tyrosine-Protein Kinase p56(lck)

Nature (London), 1989-03, Vol.338 (6212), p.257-257

1989

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The Product of the Herpesvirus saimiri Open Reading Frame 1 (Tip) Interacts with T Cell-specific Kinase p56 in Transformed Cells

The Journal of biological chemistry, 1995-03, Vol.270 (9), p.4729

1995

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Synthesis and Application of Fmoc-O-[Bis(dimethylamino)phosphono]tyrosine, a Versatile Protected Phosphotyrosine Equivalent

Journal of organic chemistry, 1995-12, Vol.60 (24), p.7710-7711

1995

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Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells

The Journal of biological chemistry, 1996-10, Vol.271 (43), p.27130-27137

1996

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Selective Activation of T Cell Kinase p56 by Herpesvirus saimiri Protein Tip

The Journal of biological chemistry, 1996-01, Vol.271 (2), p.847-852

1996

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Effects of the tyrosine‐kinase inhibitor geldanamycin on ligand‐induced HER‐2/NEU activation, receptor expression and proliferation of HER‐2‐positive malignant cell lines

International journal of cancer, 1997-01, Vol.70 (2), p.221-229

1997

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Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck

Journal of medicinal chemistry, 1993-02, Vol.36 (4), p.425-432

1993

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MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

Cancer research (Chicago, Ill.), 1997-12, Vol.57 (23), p.5221-5225

1997

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No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

Nature (London), 1990-12, Vol.348 (6301), p.557-560

1990

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Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72 Expression

The Journal of biological chemistry, 1995-11, Vol.270 (44), p.26533

1995

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Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

The Journal of biological chemistry, 1996-03, Vol.271 (11), p.6389-6397

1996

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Pillars Article: The CD4 and CD8 T Cell Surface Antigens are Associated with the Internal Membrane Tyrosine-Protein Kinase p56lck. Cell 1994. 77: 301-308

The Journal of immunology (1950), 2010-09, Vol.185 (5), p.2650-2657

2010

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CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck

The EMBO journal, 1993-01, Vol.12 (1), p.315-321

1993

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Integral membrane protein 2 of Epstein—barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

Immunity (Cambridge, Mass.), 1995-02, Vol.2 (2), p.155-166

1995

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Protein tyrosine kinases in the initiation of antigen receptor signaling

Current opinion in immunology, 1995, Vol.7 (3), p.306-311

Bolen, Joseph B.

1995

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The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

The EMBO journal, 1996-11, Vol.15 (22), p.6251-6261

1996

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors

Syk tyrosine kinase required for mouse viability and B-cell development

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy

Phenotypic analysis of human glioma cells expressing the MMAC1 tumor suppressor phosphatase

Membrane Glycoprotein IV (CD36) is Physically Associated with the Fyn, Lyn, and Yes Protein-Tyrosine Kinases in Human Platelets

Transcriptional analysis of the PTEN/MMAC1 pseudogene, ΨPTEN

Endogenous Reactive Oxygen Intermediates Activate Tyrosine Kinases in Human Neutrophils (∗)

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma

Signal Transduction through the CD4 Receptor Involves the Activation of the Internal Membrane Tyrosine-Protein Kinase p56(lck)

The Product of the Herpesvirus saimiri Open Reading Frame 1 (Tip) Interacts with T Cell-specific Kinase p56 in Transformed Cells

Synthesis and Application of Fmoc-O-[Bis(dimethylamino)phosphono]tyrosine, a Versatile Protected Phosphotyrosine Equivalent

Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells

Selective Activation of T Cell Kinase p56 by Herpesvirus saimiri Protein Tip

Effects of the tyrosine‐kinase inhibitor geldanamycin on ligand‐induced HER‐2/NEU activation, receptor expression and proliferation of HER‐2‐positive malignant cell lines

Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

Syk Mutation in Jurkat E6-derived Clones Results in Lack of p72 Expression

Physical and Functional Interactions between Lyn and p34 Kinases in Irradiated Human B-cell Precursors

Pillars Article: The CD4 and CD8 T Cell Surface Antigens are Associated with the Internal Membrane Tyrosine-Protein Kinase p56lck. Cell 1994. 77: 301-308

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck

Integral membrane protein 2 of Epstein—barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

Protein tyrosine kinases in the initiation of antigen receptor signaling

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling

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