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Are PIEZO1 channels a potential therapeutic target for heart failure? Getting to the heart of the matter

Expert opinion on therapeutic targets, 2023-06, Vol.27 (6), p.409-411

Beech, David J.

2023

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Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

Circulation Journal, 2013, Vol.77(3), pp.570-579

Beech, David J.

2013

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(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

Angewandte Chemie International Edition, 2015-03, Vol.54 (12), p.3787-3791

2015

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Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

The Journal of biological chemistry, 2017-05, Vol.292 (20), p.8158-8173

2017

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Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies

The Journal of cell biology, 2019-07, Vol.218 (7), p.2232-2246

2019

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Pico145 inhibits TRPC4-mediated mICAT and postprandial small intestinal motility

Biomedicine & pharmacotherapy, 2023-12, Vol.168, p.115672, Article 115672

2023

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Endothelial Piezo1 channels as sensors of exercise

The Journal of physiology, 2018-03, Vol.596 (6), p.979-984

Beech, David J.

2018

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Docking Domain-Mediated Subunit Interactions in Natural Product Megasynth(et)ases

Journal of industrial microbiology & biotechnology, 2021-02, Vol.48 (3-4)

2021

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Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Cells (Basel, Switzerland), 2018-06, Vol.7 (6), p.52

2018

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Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

Scientific reports, 2017-12, Vol.7 (1), p.16988-12, Article 16988

2017

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Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

Communications biology, 2020-11, Vol.3 (1), p.704-704, Article 704

2020

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ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling

Frontiers in cell and developmental biology, 2021-04, Vol.9, p.653812-653812

2021

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Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids

British journal of pharmacology, 2011-04, Vol.162 (7), p.1509-1520

2011

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Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension

Biophysical journal, 2021-04, Vol.120 (8), p.1510-1521

2021

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Mycobacterium abscessus skin and soft tissue infection following autologous fat grafting in Kurdistan treated with an antibiotic combination including Imipenem-Relebactam and Rifabutin

Journal of clinical tuberculosis and other mycobacterial diseases, 2023-08, Vol.32, p.100381, Article 100381

2023

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Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation

The Journal of biological chemistry, 2003-03, Vol.278 (13), p.11002-11006

2003

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TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca2+ Channels in Native Vascular Smooth Muscle Cells

Circulation research, 2001-01, Vol.88 (1), p.84-87

2001

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Extension of nanoconfined DNA: Quantitative comparison between experiment and theory

Physical review. E, 2015-12, Vol.92 (6), p.062701-062701, Article 062701

2015

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Generation of functional ion-channel tools by E3 targeting

Nature biotechnology, 2005-10, Vol.23 (10), p.1289-1293

2005

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Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)

Biochemical and biophysical research communications, 2010-02, Vol.393 (1), p.50-54

2010

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Simplifying microfluidic separation devices towards field-detection of blood parasites

Analytical methods, 2016-01, Vol.8 (16), p.3291-3300

2016

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Interactions, Functions, and Independence of Plasma Membrane STIM1 and TRPC1 in Vascular Smooth Muscle Cells

Circulation research, 2008-10, Vol.103 (8), p.e97-e104

2008

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Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels

Molecular pharmacology, 2011-06, Vol.79 (6), p.1023-1030

2011

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Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy

Journal of the American Heart Association, 2020-09, Vol.9 (18), p.e017091-e017091

2020

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Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands

British journal of pharmacology, 2013-03, Vol.168 (6), p.1445-1455

2013

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Are PIEZO1 channels a potential therapeutic target for heart failure? Getting to the heart of the matter

Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

(−)-Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies

Pico145 inhibits TRPC4-mediated mICAT and postprandial small intestinal motility

Endothelial Piezo1 channels as sensors of exercise

Docking Domain-Mediated Subunit Interactions in Natural Product Megasynth(et)ases

Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease

Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling

Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids

Molecular dynamics simulations of Piezo1 channel opening by increases in membrane tension

Mycobacterium abscessus skin and soft tissue infection following autologous fat grafting in Kurdistan treated with an antibiotic combination including Imipenem-Relebactam and Rifabutin

Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation

TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca2+ Channels in Native Vascular Smooth Muscle Cells

Extension of nanoconfined DNA: Quantitative comparison between experiment and theory

Generation of functional ion-channel tools by E3 targeting

Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb2+)

Simplifying microfluidic separation devices towards field-detection of blood parasites

Interactions, Functions, and Independence of Plasma Membrane STIM1 and TRPC1 in Vascular Smooth Muscle Cells

Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channels

Unique Transcriptome Signature Distinguishes Patients With Heart Failure With Myopathy

Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands

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