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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Clinical pharmacology and therapeutics, 2012-06, Vol.91 (6), p.1044-1052

2012

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Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

British journal of clinical pharmacology, 2012-08, Vol.74 (2), p.304-314

2012

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In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

European journal of clinical pharmacology, 2011-08, Vol.67 (8), p.815-824

2011

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Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease

Atherosclerosis, 2012-06, Vol.222 (2), p.530-536

2012

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Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients

Clinical pharmacology and therapeutics, 2010-11, Vol.88 (5), p.676-684

2010

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Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.533-538

2007

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A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

Clinical pharmacology and therapeutics, 2011-08, Vol.90 (2), p.221-228

2011

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Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Clinical pharmacology and therapeutics, 2005-06, Vol.77 (6), p.553-559

2005

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Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2330-2339

2009

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Losartan increases bradykinin levels in hypertensive humans

Circulation (New York, N.Y.), 2005-01, Vol.111 (3), p.315-320

2005

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Metabolism and excretion of asenapine in healthy male subjects

Drug metabolism and disposition, 2011-04, Vol.39 (4), p.580-590

2011

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Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.507-513

2013

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CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

European journal of clinical pharmacology, 2012-05, Vol.68 (5), p.637-644

2012

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Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

British journal of clinical pharmacology, 2012-12, Vol.74 (6), p.999-1004

2012

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Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Drug metabolism and disposition, 2011-01, Vol.39 (1), p.92-97

2011

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Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.439-448

2013

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GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

Therapeutic drug monitoring, 2013-08, Vol.35 (4), p.473-484

2013

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CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir

Clinical pharmacology and therapeutics, 2007-05, Vol.81 (5), p.708-712

2007

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St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

Clinical pharmacology and therapeutics, 2004-03, Vol.75 (3), p.191-197

2004

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Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects

European journal of clinical pharmacology, 2013-03, Vol.69 (3), p.523-532

2013

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No pharmacokinetic alteration of docetaxel following coadministration of aprepitant 3 h before docetaxel infusion

Cancer chemotherapy and pharmacology, 2014-09, Vol.74 (3), p.539-547

2014

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CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

Pharmacogenetics and genomics, 2006-09, Vol.16 (9), p.637-645

2006

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Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

European journal of clinical pharmacology, 2009-04, Vol.65 (4), p.403-409

2009

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10‐hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

Clinical pharmacology and therapeutics, 1998-04, Vol.63 (4), p.444-452

1998

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Hydroxylation of R(+)- and S(−)-Omeprazole after Racemic Dosing are Different among the CYP2C19 Genotypes

Pharmaceutical research, 2012-08, Vol.29 (8), p.2310-2316

2012

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PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

Simultaneous population pharmacokinetic modelling of ketamine and three major metabolites in patients with treatment‐resistant bipolar depression

In vitro–in vivo extrapolation of CYP2C8-catalyzed paclitaxel 6α-hydroxylation: effects of albumin on in vitro kinetic parameters and assessment of interindividual variability in predicted clearance

Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease

Long-Term Efavirenz Autoinduction and Its Effect on Plasma Exposure in HIV Patients

Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator

Losartan increases bradykinin levels in hypertensive humans

Metabolism and excretion of asenapine in healthy male subjects

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

CYP2D6 genotype and dextromethorphan hydroxylation phenotype in an Ecuadorian population

Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men

Effects of pregnane X receptor (NR1I2) and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin

Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin

GC-MS-based quantitative signatures of cytochrome P450-mediated steroid oxidation induced by rifampicin

CYP3A5 Genotype has an Impact on the Metabolism of the HIV Protease Inhibitor Saquinavir

St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole

Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects

No pharmacokinetic alteration of docetaxel following coadministration of aprepitant 3 h before docetaxel infusion

CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

10‐hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes

Hydroxylation of R(+)- and S(−)-Omeprazole after Racemic Dosing are Different among the CYP2C19 Genotypes

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