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Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan

Cancer research (Chicago, Ill.), 2005-08, Vol.65 (15), p.6850-6857

2005

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Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.392

2009

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Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Chemical research in toxicology, 2008-10, Vol.21 (10), p.1956-1963

2008

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Functional role of residues in the helix B′ region of cytochrome P450 2B1

Archives of biochemistry and biophysics, 2005-03, Vol.435 (1), p.157-165

2005

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Hypersensitive Radical Probes and the Mechanisms of Cytochrome P450-Catalyzed Hydroxylation Reactions

Accounts of chemical research, 2000-07, Vol.33 (7), p.449-455

2000

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Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

Archives of biochemistry and biophysics, 2004-03, Vol.423 (2), p.266-276

2004

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In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes

Xenobiotica, 2003-07, Vol.33 (7), p.717-729

2003

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Amino Acid Residues Critical for Differential Inhibition of CYP2B4, CYP2B5, and CYP2B1 by Phenylimidazoles

Molecular pharmacology, 2001-03, Vol.59 (3), p.475-484

2001

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Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

The Journal of biological chemistry, 2009-09, Vol.284 (38), p.25678-25686

2009

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Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene

The Journal of pharmacology and experimental therapeutics, 2010-06, Vol.333 (3), p.663

2010

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Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity

Molecular pharmacology, 2008-10, Vol.74 (4), p.990-999

2008

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Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene

Cancer, 2002-09, Vol.95 (5), p.1171-1181

2002

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Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: Bi-directional coupling between CYP2B1 and anionic phospholipid

Archives of biochemistry and biophysics, 2007-12, Vol.468 (2), p.226-233

2007

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Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Chemical research in toxicology, 2003-02, Vol.16 (2), p.129-136

2003

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Enhancing crop yields through improvements in the efficiency of photosynthesis and respiration

The New phytologist, 2023-01, Vol.237 (1), p.60-77

2023

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Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1

Chemical research in toxicology, 2002-11, Vol.15 (11), p.1407-1413

2002

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Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms

The Journal of pharmacology and experimental therapeutics, 2004-09, Vol.310 (3), p.1011

2004

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Biological effects of Byrsocarpus coccineus in vitro

Pharmaceutical biology, 2011-02, Vol.49 (2), p.152-160

2011

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The Highly Conserved Glu149 and Tyr190 Residues Contribute To Peroxynitrite-Mediated Nitrotyrosine Formation and the Catalytic Activity of Cytochrome P450 2B1

Chemical research in toxicology, 2005-08, Vol.18 (8), p.1203-1210

2005

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Exploring QSARs for Binding Affinity of Azoles with CYP2B and CYP3A Enzymes Using GFA and G/PLS Techniques

Chemical biology & drug design, 2008-05, Vol.71 (5), p.464-473

2008

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Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP)

DNA and cell biology, 2004-02, Vol.23 (2), p.81

2004

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2,2‘,3,3‘,6,6‘-Hexachlorobiphenyl Hydroxylation by Active Site Mutants of Cytochrome P450 2B1 and 2B11

Chemical research in toxicology, 1999-08, Vol.12 (8), p.690-699

1999

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Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism

Biochemical and biophysical research communications, 2005-12, Vol.338 (1), p.386-393

2005

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P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct

Journal of the American Chemical Society, 2005-02, Vol.127 (5), p.1376-1377

2005

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Structure–Function Analysis of Human Cytochrome P450 3A4 Using 7-Alkoxycoumarins as Active-Site Probes

Archives of biochemistry and biophysics, 2000-01, Vol.373 (2), p.335-345

2000

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Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan

Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein

Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Functional role of residues in the helix B′ region of cytochrome P450 2B1

Hypersensitive Radical Probes and the Mechanisms of Cytochrome P450-Catalyzed Hydroxylation Reactions

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes

Amino Acid Residues Critical for Differential Inhibition of CYP2B4, CYP2B5, and CYP2B1 by Phenylimidazoles

Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene

Investigation of the Mechanisms Underlying the Differential Effects of the K262R Mutation of P450 2B6 on Catalytic Activity

Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene

Lateral segregation of anionic phospholipids in model membranes induced by cytochrome P450 2B1: Bi-directional coupling between CYP2B1 and anionic phospholipid

Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Enhancing crop yields through improvements in the efficiency of photosynthesis and respiration

Substrate Routes to the Buried Active Site May Vary among Cytochromes P450: Mutagenesis of the F−G Region in P450 2B1

Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms

Biological effects of Byrsocarpus coccineus in vitro

The Highly Conserved Glu149 and Tyr190 Residues Contribute To Peroxynitrite-Mediated Nitrotyrosine Formation and the Catalytic Activity of Cytochrome P450 2B1

Exploring QSARs for Binding Affinity of Azoles with CYP2B and CYP3A Enzymes Using GFA and G/PLS Techniques

Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP)

2,2‘,3,3‘,6,6‘-Hexachlorobiphenyl Hydroxylation by Active Site Mutants of Cytochrome P450 2B1 and 2B11

Roles of the threonine 407, aspartic acid 417, and threonine 419 residues in P450 2B1 in metabolism

P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct

Structure–Function Analysis of Human Cytochrome P450 3A4 Using 7-Alkoxycoumarins as Active-Site Probes

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