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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells

Cancer research (Chicago, Ill.), 2007-01, Vol.67 (2), p.746-755

2007

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Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Blood, 2001-07, Vol.98 (1), p.210-216

2001

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Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1222-1232

2003

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1522-1524

2009

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Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (18), p.7347-7356

2009

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A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

Journal of translational medicine, 2004-01, Vol.2 (1), p.4-4, Article 4

2004

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Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Pancreas, 2009-01, Vol.38 (1), p.78-84

2009

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Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3238-3240

1996

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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

The Journal of immunology (1950), 1999-07, Vol.163 (1), p.380-386

1999

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Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1625-1630

1999

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Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Journal of clinical immunology, 2001-09, Vol.21 (5), p.357-364

2001

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Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Cellular immunology, 2004-08, Vol.230 (2), p.81-88

2004

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Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-θ Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-κB, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604-616

2005

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Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1

Journal of medicinal chemistry, 1992-05, Vol.35 (10), p.1747-1751

1992

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Lenalidomide and CC-4047 Inhibit the Proliferation of Malignant B Cells while Expanding Normal CD34 super(+) Progenitor Cells

Cancer research (Chicago, Ill.), 2007-01, Vol.67 (2), p.746-755

2007

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Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro

AIDS research and human retroviruses, 1997-07, Vol.13 (10), p.857-863

1997

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Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-[theta] Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-[kappa]B, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604

2005

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Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT

Journal of interferon & cytokine research, 2005-10, Vol.25 (10), p.604

2005

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Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (18), p.7347-7356

2009

Volltextzugriff (PDF)

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Cellular immunology, 2004-08, Vol.230 (2), p.81-88

2004

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Thalidomide analogs, but not thalidomide itself, are potent inhMitors of lamina propria mononuclear cell (LPMC) TNF-A and IFN-कproduction in response to T cell stimuli

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A586-A586

2000

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TNF-α inhibitors and rheumatoid arthritis

Expert opinion on therapeutic patents, 1998-05, Vol.8 (5), p.531-544

1998

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TNF- inhibitors and rheumatoid arthritis

Expert opinion on therapeutic patents, 1998-05, Vol.8 (5), p.531-544

1998

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A regiospecific and highly stereoselective approach to the synthesis of linearly fused tricyclopentanoids. Intramolecular diyl trapping reactions

Journal of the American Chemical Society, 1979-11, Vol.101 (23), p.7129-7130

1979

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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells

Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-a Inhibitor

Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

A novel technique for quantifying changes in vascular density, endothelial cell proliferation and protein expression in response to modulators of angiogenesis using the chick chorioallantoic membrane (CAM) assay

Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells

Structural Modifications of Thalidomide Produce Analogs with Enhanced Tumor Necrosis Factor Inhibitory Activity

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha

Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production

Potent inhibition of cytokine production from intestinal lamina propria T cells by phosphodiesterase-4 inhibitory thalidomide analogues

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-α, IL-1β, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-θ Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-κB, OCT-1, or NF-AT

Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1

Lenalidomide and CC-4047 Inhibit the Proliferation of Malignant B Cells while Expanding Normal CD34 super(+) Progenitor Cells

Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro

Immunomodulatory Drugs (IMiDs) Increase the Production of IL-2 from Stimulated T Cells by Increasing PKC-[theta] Activation and Enhancing the DNA-Binding Activity of AP-1 but Not NF-[kappa]B, OCT-1, or NF-AT

Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT

Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma and multiple myeloma through a LSD1-mediated epigenetic mechanism

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner

Thalidomide analogs, but not thalidomide itself, are potent inhMitors of lamina propria mononuclear cell (LPMC) TNF-A and IFN-कproduction in response to T cell stimuli

TNF-α inhibitors and rheumatoid arthritis

TNF- inhibitors and rheumatoid arthritis

A regiospecific and highly stereoselective approach to the synthesis of linearly fused tricyclopentanoids. Intramolecular diyl trapping reactions

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