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PBPK models for the prediction of in vivo performance of oral dosage forms

European journal of pharmaceutical sciences, 2014-06, Vol.57 (SI), p.300-321

2014

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Prediction of intestinal first-pass drug metabolism

Current drug metabolism, 2007-10, Vol.8 (7), p.676

2007

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Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Drug metabolism and pharmacokinetics, 2016-06, Vol.31 (3), p.224-233

2016

Volltextzugriff (PDF)

Biopharmaceutic IVIVE—Mechanistic Modeling of Single- and Two-Phase In Vitro Experiments to Obtain Drug-Specific Parameters for Incorporation Into PBPK Models

Journal of pharmaceutical sciences, 2019-04, Vol.108 (4), p.1604-1618

2019

Volltextzugriff (PDF)

The Simcyp® Population-based ADME Simulator

Expert opinion on drug metabolism & toxicology, 2009-02, Vol.5 (2), p.211-223

2009

Volltextzugriff (PDF)

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Drug metabolism and disposition, 2016-06, Vol.44 (6), p.821-832

2016

Volltextzugriff (PDF)

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs

The AAPS journal, 2017-07, Vol.19 (4), p.1205-1217

2017

Volltextzugriff (PDF)

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: A case study using the BCS/BDDCS Class II drug nifedipine

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.240-249

2014

Volltextzugriff (PDF)

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

The AAPS journal, 2016-09, Vol.18 (5), p.1144-1158

2016

Volltextzugriff (PDF)

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3145-3160

2013

Volltextzugriff (PDF)

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution

Journal of pharmacy and pharmacology, 2012-07, Vol.64 (7), p.1008-1024

2012

Volltextzugriff (PDF)

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PBPK models for the prediction of in vivo performance of oral dosage forms

Prediction of intestinal first-pass drug metabolism

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

Biopharmaceutic IVIVE—Mechanistic Modeling of Single- and Two-Phase In Vitro Experiments to Obtain Drug-Specific Parameters for Incorporation Into PBPK Models

The Simcyp® Population-based ADME Simulator

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: A case study using the BCS/BDDCS Class II drug nifedipine

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

Application of permeability-limited physiologically-based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution

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