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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

Nature nanotechnology, 2019-08, Vol.14 (8), p.799-809

2019

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DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Clinical cancer research, 2016-10, Vol.22 (20), p.5097-5108

2016

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Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy

ACS nano, 2017-09, Vol.11 (9), p.8838-8848

2017

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Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

Advanced materials (Weinheim), 2014-06, Vol.26 (21), p.3433-3440

2014

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The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

ACS nano, 2015-07, Vol.9 (7), p.7195-7206

2015

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Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

The Journal of clinical investigation, 2017-05, Vol.127 (5), p.2007-2018

2017

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Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect

Nature reviews. Clinical oncology, 2016-11, Vol.13 (11), p.659-673

2016

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Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

Journal of the American Chemical Society, 2012-08, Vol.134 (30), p.12668-12674

2012

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Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

World journal of gastroenterology : WJG, 2015-11, Vol.21 (43), p.12234-12248

2015

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Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer

ACS nano, 2016-02, Vol.10 (2), p.2702-2715

2016

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The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (9), p.4518-4526

2020

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Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma

Journal of controlled release, 2017-08, Vol.259, p.136-148

2017

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Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers

Bioconjugate chemistry, 2015-05, Vol.26 (5), p.919-931

2015

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Near-Infrared Light-Activated Photochemical Internalization of Reduction-Responsive Polyprodrug Vesicles for Synergistic Photodynamic Therapy and Chemotherapy

Biomacromolecules, 2017-08, Vol.18 (8), p.2571-2582

2017

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Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Journal of controlled release, 2017-02, Vol.247, p.28-54

2017

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Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

Journal of clinical oncology, 2016-04, Vol.34 (12), p.1368-1375

2016

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CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3850-3854

2016

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Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)

Current medicinal chemistry, 2017-01, Vol.24 (2), p.193

2017

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An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Angewandte Chemie (International ed.), 2014-04, Vol.53 (17), p.4469-4474

International ed. in English, 2014

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Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

Advanced materials (Weinheim), 2013-08, Vol.25 (32), p.4452-4458

2013

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Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity

European journal of pharmaceutics and biopharmaceutics, 2010-02, Vol.74 (2), p.193-201

2010

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Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis

Clinical cancer research, 2021-07, Vol.27 (14), p.3970-3979

2021

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Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

International journal of pharmaceutics, 2018-10, Vol.549 (1-2), p.352-362

2018

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Synergistic Combination Chemotherapy of Camptothecin and Floxuridine through Self-Assembly of Amphiphilic Drug–Drug Conjugate

Bioconjugate chemistry, 2015-12, Vol.26 (12), p.2497-2506

2015

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Enhancing SN38 prodrug delivery using a self-immolative linker and endogenous albumin transport

Journal of controlled release, 2024-05, Vol.369, p.622-629

2024

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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1

Transformative Nanomedicine of an Amphiphilic Camptothecin Prodrug for Long Circulation and High Tumor Uptake in Cancer Therapy

Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment

Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer

Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer

Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer

The role of critical micellization concentration in efficacy and toxicity of supramolecular polymers

Positively charged polypeptide nanogel enhances mucoadhesion and penetrability of 10-hydroxycamptothecin in orthotopic bladder carcinoma

Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers

Near-Infrared Light-Activated Photochemical Internalization of Reduction-Responsive Polyprodrug Vesicles for Synergistic Photodynamic Therapy and Chemotherapy

Safe approaches for camptothecin delivery: Structural analogues and nanomedicines

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)

An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity

Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis

Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery

Synergistic Combination Chemotherapy of Camptothecin and Floxuridine through Self-Assembly of Amphiphilic Drug–Drug Conjugate

Enhancing SN38 prodrug delivery using a self-immolative linker and endogenous albumin transport

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