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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Cell reports. Medicine, 2020-07, Vol.1 (4), p.100057-100057, Article 100057

2020

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Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood

PLoS computational biology, 2010-09, Vol.6 (9), p.e1000950

2010

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Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study

Frontiers in neuroscience, 2024-02, Vol.18, p.1302714-1302714

2024

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Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria

Communications biology, 2021-07, Vol.4 (1), p.898-898, Article 898

2021

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An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Science translational medicine, 2019-01, Vol.11 (475)

2019

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Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)

British journal of clinical pharmacology, 2010-01, Vol.69 (1), p.15-22

2010

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Pharmacokinetics and Pharmacodynamics of MK-5046, a Bombesin Receptor Subtype-3 (BRS-3) Agonist, in Healthy Patients

Journal of clinical pharmacology, 2012-09, Vol.52 (9), p.1306-1316

2012

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Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects

British journal of clinical pharmacology, 2017-02, Vol.83 (2), p.326-338

2017

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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Cell host & microbe, 2024-03, Vol.32 (3), p.382-395.e10

2024

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Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray

Biotechnology and bioengineering, 2006-08, Vol.94 (6), p.1099-1110

2006

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Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

European journal of pain, 2019-07, Vol.23 (6), p.1129-1140

2019

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Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

Blood, 2008-04, Vol.111 (7), p.3507-3513

2008

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Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Journal of veterinary pharmacology and therapeutics, 2021-07, Vol.44 (4), p.533-543

2021

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Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates

Clinical and translational science, 2018-03, Vol.11 (2), p.200-207

2018

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Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Nature metabolism, 2023-10, Vol.5 (10), p.1685

2023

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Characterizing the PK/PD relationship for inhibition of capsaicin‐induced dermal vasodilatation by MK‐3207, an oral calcitonin gene related peptide receptor antagonist

British journal of clinical pharmacology, 2015-05, Vol.79 (5), p.831-837

2015

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Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator

Drug metabolism and disposition, 2014-11, Vol.42 (11), p.1926

2014

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A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design

The AAPS journal, 2014-11, Vol.16 (6), p.1259-1270

2014

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COMPARISON OF PHENYLALANINE ABSORPTION IN HEALTHY VOLUNTEERS AND PKU PATIENTS IN THE SYNPHENY-1 STUDY

Molecular genetics and metabolism, 2022-04, Vol.135 (4), p.295-295

2022

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Stochastic Modeling of Blood Coagulation Initiation

Pathophysiology of haemostasis and thrombosis, 2005-01, Vol.34 (2-3), p.80-90

2005

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Abstract 5548: The therapeutic potential of AMV564, a novel bispecific bivalent (2x2) T-cell engager, for the treatment of CD33-expressing hematologic malignancies

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5548-5548

2018

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Hyper-Sialylated IgG M254, an Innovative Therapeutic Candidate, Evaluated in Healthy Volunteers and in Patients with Immune Thrombocytopenia Purpura: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics

Blood, 2019-11, Vol.134 (Supplement_1), p.1090-1090

2019

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SBML Level 3: an extensible format for the exchange and reuse of biological models

Molecular systems biology, 2020-08, Vol.16 (8), p.e9110-n/a

2020

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A Quantitative Systems Pharmacology Model for the Coagulation Network Describes Biomarker Changes Observed in a Clinical Study with FXa Variant and Predicts Age-Associated Biomarker Variations

Blood, 2015-12, Vol.126 (23), p.3502-3502

2015

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Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood: e1000950

PLoS computational biology, 2010-09, Vol.6 (9)

2010

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AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood

Pharmacokinetics and pharmacodynamics across infusion rates of intravenously administered nipocalimab: results of a phase 1, placebo-controlled study

Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Inhibition of capsaicin‐induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK‐0974)

Pharmacokinetics and Pharmacodynamics of MK-5046, a Bombesin Receptor Subtype-3 (BRS-3) Agonist, in Healthy Patients

Pharmacokinetics and pharmacodynamics of PF‐05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects

The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers

Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray

Reproducibility of a battery of human evoked pain models to detect pharmacological effects of analgesic drugs

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses

Translational Development of Microbiome‐Based Therapeutics: Kinetics of E. coli Nissle and Engineered Strains in Humans and Nonhuman Primates

Efficacy and safety of a synthetic biotic for treatment of phenylketonuria: a phase 2 clinical trial

Characterizing the PK/PD relationship for inhibition of capsaicin‐induced dermal vasodilatation by MK‐3207, an oral calcitonin gene related peptide receptor antagonist

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator

A Semi-mechanistic Model for the Effects of a Novel Glucagon Receptor Antagonist on Glucagon and the Interaction Between Glucose, Glucagon, and Insulin Applied to Adaptive Phase II Design

COMPARISON OF PHENYLALANINE ABSORPTION IN HEALTHY VOLUNTEERS AND PKU PATIENTS IN THE SYNPHENY-1 STUDY

Stochastic Modeling of Blood Coagulation Initiation

Abstract 5548: The therapeutic potential of AMV564, a novel bispecific bivalent (2x2) T-cell engager, for the treatment of CD33-expressing hematologic malignancies

Hyper-Sialylated IgG M254, an Innovative Therapeutic Candidate, Evaluated in Healthy Volunteers and in Patients with Immune Thrombocytopenia Purpura: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics

SBML Level 3: an extensible format for the exchange and reuse of biological models

A Quantitative Systems Pharmacology Model for the Coagulation Network Describes Biomarker Changes Observed in a Clinical Study with FXa Variant and Predicts Age-Associated Biomarker Variations

Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood: e1000950

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