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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

Diabetes (New York, N.Y.), 2009-09, Vol.58 (9), p.2006-2017

2009

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Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

Oncotarget, 2016-02, Vol.7 (5), p.5461-5469

2016

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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Science (American Association for the Advancement of Science), 1999-03, Vol.283 (5407), p.1544-1548

1999

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Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation

Cancer medicine (Malden, MA), 2020-05, Vol.9 (10), p.3371-3382

2020

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Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

The Journal of biological chemistry, 2001-02, Vol.276 (6), p.4469-4475

2001

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Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

Canadian journal of anesthesia, 2018-09, Vol.65 (9), p.1041-1056

2018

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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Journal of lipid research, 2011-08, Vol.52 (8), p.1494-1499

2011

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Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor

Bioorganic & medicinal chemistry letters, 2024-07, Vol.107, p.129769-129769, Article 129769

2024

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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)

Bioorganic & medicinal chemistry letters, 2022-06, Vol.66, p.128734-128734, Article 128734

2022

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Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127601-127601, Article 127601

2020

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HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

Journal of thoracic oncology, 2014-03, Vol.9 (3), p.285-294

2014

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Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development

Oncotarget, 2015-08, Vol.6 (24), p.20160-20176

2015

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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

The Journal of pharmacology and experimental therapeutics, 2019-02, Vol.368 (2), p.299-307

2019

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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9

Diabetes (New York, N.Y.), 2005-10, Vol.54 (10), p.2988-2994

2005

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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Journal of medicinal chemistry, 2011-07, Vol.54 (14), p.5082-5096

2011

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Substituted coumarins as potent 5-lipoxygenase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2528-2531

2006

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5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates the Release of the Eosinophil Survival Factor Granulocyte/Macrophage Colony-stimulating Factor from Monocytes

The Journal of biological chemistry, 2004-07, Vol.279 (27), p.28159-28164

2004

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

The Journal of immunology (1950), 2003-05, Vol.170 (9), p.4738-4744

2003

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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

British journal of pharmacology, 1999-02, Vol.126 (4), p.979-988

1999

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Clinical characteristics of COVID‐19 patients infected by the Omicron variants in Macao, China: A cross‐sectional study

Health science reports, 2023-07, Vol.6 (7), p.e1361-n/a

2023

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SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro

PloS one, 2013-01, Vol.8 (1), p.e54572

2013

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Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

British journal of pharmacology, 1999-10, Vol.128 (4), p.853-859

1999

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In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

American journal of veterinary research, 2001-11, Vol.62 (11), p.1755-1760

2001

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7281-7286

2011

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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation

Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)

Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)

HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development

Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Substituted coumarins as potent 5-lipoxygenase inhibitors

5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates the Release of the Eosinophil Survival Factor Granulocyte/Macrophage Colony-stimulating Factor from Monocytes

Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

Clinical characteristics of COVID‐19 patients infected by the Omicron variants in Macao, China: A cross‐sectional study

SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro

Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

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