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Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo

British journal of pharmacology, 2006-11, Vol.149 (6), p.666-675

2006

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Bronchodilator and anti‐inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

British journal of pharmacology, 1999-08, Vol.127 (7), p.1641-1651

1999

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Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist

Naunyn-Schmiedeberg's archives of pharmacology, 1997-09, Vol.356 (3), p.328-334

1997

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Resident Cell Chemokine Expression Serves as the Major Mechanism for Leukocyte Recruitment During Local Inflammation

The Journal of immunology (1950), 2002-12, Vol.169 (11), p.6467-6473

2002

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Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization

British journal of pharmacology, 1997-05, Vol.121 (2), p.171-180

1997

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Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483

Bioorganic & medicinal chemistry, 1999-12, Vol.7 (12), p.2891-2897

1999

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Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2000-01, Vol.43 (2), p.214-223

2000

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Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2004-07, Vol.47 (15), p.3874-3886

2004

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Synthesis and Structure−Activity Relationships of Novel Histamine H 1 Antagonists: Indolylpiperidinyl Benzoic Acid Derivatives

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6326-6337

2004

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Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors

Journal of medicinal chemistry, 2000-02, Vol.43 (4), p.683-689

2000

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Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors

Farmaco (Società chimica italiana : 1989), 1995-12, Vol.50 (12), p.819

1995

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Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine

European journal of pharmacology, 2000-12, Vol.410 (1), p.33-41

2000

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Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.1165-1167

2005

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Studies on the cardiac actions of flosequinan in vitro

British journal of pharmacology, 1992-04, Vol.105 (4), p.985-991

1992

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Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3- c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (23), p.2661-2664

2000

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Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1417-1421

1997

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Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A sub(2B) Adenosine Receptor Antagonist

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2732-2736

2007

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Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation

Cellular Immunology, 2006-07, Vol.242 (1), p.31-38

2006

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Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

Bioorganic & medicinal chemistry letters, 1998-03, Vol.8 (5), p.505-510

1998

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Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors

Journal of medicinal chemistry, 1998-10, Vol.41 (21), p.4021-4035

1998

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Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle

European journal of pharmacology, 1999-06, Vol.374 (2), p.249-254

1999

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Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

British journal of pharmacology, 1997-07, Vol.121 (6), p.1150-1154

1997

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Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor

British journal of pharmacology, 1998-03, Vol.123 (6), p.1047-1054

1998

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Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies

European journal of medicinal chemistry, 1998-10, Vol.33 (10), p.789-797

1998

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Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

Journal of enzyme inhibition and medicinal chemistry, 2002-01, Vol.17 (4), p.227-233

2002

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Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo

Bronchodilator and anti‐inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes

Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist

Resident Cell Chemokine Expression Serves as the Major Mechanism for Leukocyte Recruitment During Local Inflammation

Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization

Synthesis and biological evaluation of a conformationally free seco-analogue of the immunosuppressant FR901483

Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Synthesis and Biological Evaluation of 2-Phenylpyran-4-ones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

Synthesis and Structure−Activity Relationships of Novel Histamine H 1 Antagonists: Indolylpiperidinyl Benzoic Acid Derivatives

Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors

Second messenger systems as targets for new therapeutic agents: focus on selective phosphodiesterase inhibitors

Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine

Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

Studies on the cardiac actions of flosequinan in vitro

Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3- c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Discovery and Characterization of 4'-(2-Furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a Potent, Selective, and Efficacious A sub(2B) Adenosine Receptor Antagonist

Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation

Phosphodiesterase inhibitory properties of losartan. design and synthesis of new lead compounds

Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors

Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle

Inhibition of eotaxin‐mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram

Functional and biochemical evidence for diazepam as a cyclic nucleotide phosphodiesterase type 4 inhibitor

Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies

Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

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