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The Use of Modeling and Simulation to Guide Clinical Development of Olmesartan Medoxomil in Pediatric Subjects

Clinical pharmacology and therapeutics, 2012-02, Vol.91 (2), p.250-256

2012

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Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation

Thrombosis and haemostasis, 2010-09, Vol.104 (3), p.633-641

2010

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Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation

Thrombosis and haemostasis, 2012-05, Vol.107 (5), p.925-934

2012

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Prospective dose prediction for FXa inhibitor otamixaban (OTAM) using PK/PD simulations accounting for non-dose proportional plasma exposure

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P40-P40

2005

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Usability of a novel digital medicine system in adults with schizophrenia treated with sensor-embedded tablets of aripiprazole

Neuropsychiatric disease and treatment, 2016-01, Vol.12, p.2587-2594

2016

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PK/PD of inhaled corticosteroids: The risk/benefit of inhaled ciclesonide

Journal of allergy and clinical immunology, 2003-02, Vol.111 (2), p.S218-S218

2003

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Characterisation of exposure versus response of edoxaban in patients undergoing total hip replacement surgery

Thrombosis and haemostasis, 2012-11, Vol.108 (5), p.887-895

2012

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Ciclesonide, a novel inhaled steroid, has no effect on hypothalamic-pituitary-adrenal (HPA)-axis function in mild-to-moderate asthmatics

Journal of allergy and clinical immunology, 2003-02, Vol.111 (2), p.S218-S218

2003

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High doses of the novel inhaled steroid ciclesonide have no effect on HPA-axis function in patients with moderate-to-severe persistent asthma

Journal of allergy and clinical immunology, 2003-02, Vol.111 (2), p.S216-S216

2003

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Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists

Birth defects research. Part B. Developmental and reproductive toxicology, 2004-04, Vol.71 (2), p.69-79

2004

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Risk-Benefit Value of Inhaled Glucocorticoids: A Pharmacokinetic/ Pharmacodynamic Perspective

Journal of clinical pharmacology, 2004-01, Vol.44 (1), p.37-47

2004

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Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide

American journal of therapeutics, 2005-05, Vol.12 (3), p.201

2005

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Non-compartmental analysis of pharmacokinetic data after multiple intravenous and oral administration

Pharmazie, 1997-07, Vol.52 (7), p.529-532

1997

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Risk-benefit value of inhaled corticosteroids: A pharmacokinetic/ pharmacodynamic perspective

Chest, 2003-03, Vol.123 (3), p.430S-431S

2003

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Are there lessons to be learned from drug development that will accelerate the use of molecular imaging probes in the clinic?

Nuclear medicine and biology, 2005-10, Vol.32 (7), p.657-662

2005

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Pharmacokinetics of Triamcinolone Acetonide After Intravenous, Oral, and Inhaled Administration

Journal of clinical pharmacology, 1995-03, Vol.35 (3), p.302-305

1995

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Mathematical modeling of cortisol circadian rhythm and cortisol suppression

European journal of pharmaceutical sciences, 1996-11, Vol.4 (6), p.341-350

1996

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Pharmacokinetics/Pharmacodynamics in Drug Development: An Industrial Perspective

Journal of clinical pharmacology, 2000-12, Vol.40 (12), p.1428-1438

2000

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1133 Ebastine 20 mg once daily (OD) given with food (EWF) or without food (EWOF) is equally efficacious in the treatment of seasonal allergic rhinitis (SAR)

Journal of allergy and clinical immunology, 2000, Vol.105 (1), p.S388-S388

2000

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Absolute Oral Versus Inhaled Bioavailability: Significance for Inhaled Drugs with Special Reference to Inhaled Glucocorticoids

Journal of clinical pharmacology, 1999-07, Vol.39 (7), p.661-663

1999

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Dependency of Cortisol Suppression on the Administration Time of Inhaled Corticosteroids

Journal of clinical pharmacology, 1997-08, Vol.37 (8), p.704-710

1997

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Selegiline percutaneous absorption in various species and metabolism by human skin

Pharmaceutical research, 1997, Vol.14 (1), p.50-55

1997

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Pharmacokinetic/Pharmacodynamic Modeling of Cortisol Suppression after Oral Administration of Fluocortolone

Journal of clinical pharmacology, 1996-04, Vol.36 (4), p.311-314

1996

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Pharmacokinetics and safety of a selegiline transdermal system relative to single-dose oral administration in the elderly

American journal of therapeutics, 1996-10, Vol.3 (10), p.688-698

1996

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Disposition and Blood Cell Effects of Prednisolone and Methylprednisolone

Clinical pharmacology and therapeutics, 1996-02, Vol.59 (2), p.207-207

1996

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The Use of Modeling and Simulation to Guide Clinical Development of Olmesartan Medoxomil in Pediatric Subjects

Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation

Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation

Prospective dose prediction for FXa inhibitor otamixaban (OTAM) using PK/PD simulations accounting for non-dose proportional plasma exposure

Usability of a novel digital medicine system in adults with schizophrenia treated with sensor-embedded tablets of aripiprazole

PK/PD of inhaled corticosteroids: The risk/benefit of inhaled ciclesonide

Characterisation of exposure versus response of edoxaban in patients undergoing total hip replacement surgery

Ciclesonide, a novel inhaled steroid, has no effect on hypothalamic-pituitary-adrenal (HPA)-axis function in mild-to-moderate asthmatics

High doses of the novel inhaled steroid ciclesonide have no effect on HPA-axis function in patients with moderate-to-severe persistent asthma

Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists

Risk-Benefit Value of Inhaled Glucocorticoids: A Pharmacokinetic/ Pharmacodynamic Perspective

Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide

Non-compartmental analysis of pharmacokinetic data after multiple intravenous and oral administration

Risk-benefit value of inhaled corticosteroids: A pharmacokinetic/ pharmacodynamic perspective

Are there lessons to be learned from drug development that will accelerate the use of molecular imaging probes in the clinic?

Pharmacokinetics of Triamcinolone Acetonide After Intravenous, Oral, and Inhaled Administration

Mathematical modeling of cortisol circadian rhythm and cortisol suppression

Pharmacokinetics/Pharmacodynamics in Drug Development: An Industrial Perspective

1133 Ebastine 20 mg once daily (OD) given with food (EWF) or without food (EWOF) is equally efficacious in the treatment of seasonal allergic rhinitis (SAR)

Absolute Oral Versus Inhaled Bioavailability: Significance for Inhaled Drugs with Special Reference to Inhaled Glucocorticoids

Dependency of Cortisol Suppression on the Administration Time of Inhaled Corticosteroids

Selegiline percutaneous absorption in various species and metabolism by human skin

Pharmacokinetic/Pharmacodynamic Modeling of Cortisol Suppression after Oral Administration of Fluocortolone

Pharmacokinetics and safety of a selegiline transdermal system relative to single-dose oral administration in the elderly

Disposition and Blood Cell Effects of Prednisolone and Methylprednisolone

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