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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

The Journal of clinical investigation, 2020-01, Vol.130 (1), p.258-271

2020

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Nature communications, 2019-11, Vol.10 (1), p.5065-15, Article 5065

2019

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Molecular cancer therapeutics, 2018-05, Vol.17 (5), p.885-896

2018

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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Journal of medicinal chemistry, 2020-04, Vol.63 (7), p.3461-3471

2020

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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8249-8267

2014

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Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7025-7048

2013

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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13704-13718

2021

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Feedbacks between sea-floor spreading, trade winds and precipitation in the Southern Red Sea

Nature communications, 2022-09, Vol.13 (1), p.5405-5405, Article 5405

2022

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Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases

Immunological reviews, 2014-05, Vol.259 (1), p.206-230

2014

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AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Cancer discovery, 2014-09, Vol.4 (9), p.1046-1061

2014

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Construction of a dense SNP map of a highly heterozygous diploid potato population and QTL analysis of tuber shape and eye depth

Theoretical and applied genetics, 2014-10, Vol.127 (10), p.2159-2171

2014

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Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

Frontiers in immunology, 2019-06, Vol.10, p.1266-1266

2019

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Formation of hybrid arc andesites beneath thick continental crust

Earth and planetary science letters, 2011-03, Vol.303 (3-4), p.337-347

2011

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Improving breeding efficiency in potato using molecular and quantitative genetics

Theoretical and applied genetics, 2014-11, Vol.127 (11), p.2279-2292

2014

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The role of mantle melting in granite-associated hydrothermal systems: He–Ar isotopes in fluids responsible for Sn–Ag–Pb–Zn mineralization in northeast China

Mineralium deposita, 2023-11, Vol.58 (8), p.1421-1443

2023

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Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

Nature communications, 2017-12, Vol.8 (1), p.1923-11, Article 1923

2017

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Association between temperature exposure and cognition: a cross-sectional analysis of 20,687 aging adults in the United States

BMC public health, 2021-07, Vol.21 (1), p.1484-12, Article 1484

2021

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Coping During the COVID-19 Pandemic: A Qualitative Study of Older Adults Across the United States

Frontiers in public health, 2021-04, Vol.9, p.643807-643807

2021

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Cohort profile: the COVID-19 Coping Study, a longitudinal mixed-methods study of middle-aged and older adults’ mental health and well-being during the COVID-19 pandemic in the USA

BMJ open, 2021-02, Vol.11 (2), p.e044965-e044965

2021

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How local crustal thermal properties influence the amount of denudation derived from low-temperature thermochronometry

Geology (Boulder), 2017-09, Vol.45 (9), p.779-782

2017

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Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Scientific reports, 2018-09, Vol.8 (1), p.13952-16, Article 13952

2018

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Late Cretaceous to Late Eocene Exhumation in the Nima Area, Central Tibet: Implications for Development of Low Relief Topography of the Tibetan Plateau

Tectonics (Washington, D.C.), 2022-03, Vol.41 (3), p.n/a

2022

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Synthesis and Reactivity of Acyclic Germanimines: Silyl Rearrangement and Cycloadditions

Inorganic chemistry, 2021-06, Vol.60 (11), p.8293-8303

2021

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance

Feedbacks between sea-floor spreading, trade winds and precipitation in the Southern Red Sea

Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Construction of a dense SNP map of a highly heterozygous diploid potato population and QTL analysis of tuber shape and eye depth

Divergent Roles for the IL-1 Family in Gastrointestinal Homeostasis and Inflammation

Formation of hybrid arc andesites beneath thick continental crust

Improving breeding efficiency in potato using molecular and quantitative genetics

The role of mantle melting in granite-associated hydrothermal systems: He–Ar isotopes in fluids responsible for Sn–Ag–Pb–Zn mineralization in northeast China

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Association between temperature exposure and cognition: a cross-sectional analysis of 20,687 aging adults in the United States

Coping During the COVID-19 Pandemic: A Qualitative Study of Older Adults Across the United States

Cohort profile: the COVID-19 Coping Study, a longitudinal mixed-methods study of middle-aged and older adults’ mental health and well-being during the COVID-19 pandemic in the USA

How local crustal thermal properties influence the amount of denudation derived from low-temperature thermochronometry

Neogene fluvial landscape evolution in the hyperarid core of the Atacama Desert

Late Cretaceous to Late Eocene Exhumation in the Nima Area, Central Tibet: Implications for Development of Low Relief Topography of the Tibetan Plateau

Synthesis and Reactivity of Acyclic Germanimines: Silyl Rearrangement and Cycloadditions

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