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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

Diabetes (New York, N.Y.), 2009-09, Vol.58 (9), p.2006-2017

2009

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Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

Oncotarget, 2016-02, Vol.7 (5), p.5461-5469

2016

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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

The Journal of clinical investigation, 2002-10, Vol.110 (7), p.1045-1052

2002

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Science (American Association for the Advancement of Science), 1999-03, Vol.283 (5407), p.1544-1548

1999

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Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

The Journal of biological chemistry, 2001-02, Vol.276 (6), p.4469-4475

2001

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Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

Canadian journal of anesthesia, 2018-09, Vol.65 (9), p.1041-1056

2018

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Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Journal of lipid research, 2011-08, Vol.52 (8), p.1494-1499

2011

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Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor

Bioorganic & medicinal chemistry letters, 2024-07, Vol.107, p.129769-129769, Article 129769

2024

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Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)

Bioorganic & medicinal chemistry letters, 2022-06, Vol.66, p.128734-128734, Article 128734

2022

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Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127601-127601, Article 127601

2020

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HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

Journal of thoracic oncology, 2014-03, Vol.9 (3), p.285-294

2014

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Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development

Oncotarget, 2015-08, Vol.6 (24), p.20160-20176

2015

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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

The Journal of pharmacology and experimental therapeutics, 2019-02, Vol.368 (2), p.299

2019

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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9

Diabetes (New York, N.Y.), 2005-10, Vol.54 (10), p.2988-2994

2005

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Substituted coumarins as potent 5-lipoxygenase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2528-2531

2006

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5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates the Release of the Eosinophil Survival Factor Granulocyte/Macrophage Colony-stimulating Factor from Monocytes

The Journal of biological chemistry, 2004-07, Vol.279 (27), p.28159-28164

2004

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Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

The Journal of immunology (1950), 2003-05, Vol.170 (9), p.4738-4744

2003

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The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

British journal of pharmacology, 1999-02, Vol.126 (4), p.979-988

1999

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Clinical characteristics of COVID‐19 patients infected by the Omicron variants in Macao, China: A cross‐sectional study

Health science reports, 2023-07, Vol.6 (7), p.e1361-n/a

2023

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In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

American journal of veterinary research, 2001-11, Vol.62 (11), p.1755-1760

2001

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7281-7286

2011

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Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.479-483

2011

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SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1593-1597

2010

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Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3200-3205

2008

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The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation

Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors

Discovery and preclinical evaluations of TQB3616, a novel CDK4-biased inhibitor

Discovery and preclinical profile of LX-039, a novel indole-based oral selective estrogen receptor degrader (SERD)

Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)

HIP1–ALK, A Novel ALK Fusion Variant that Responds to Crizotinib

Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development

Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes : Potential importance of selectivity over dipeptidyl peptidases 8 and 9

Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

Substituted coumarins as potent 5-lipoxygenase inhibitors

5-Oxo-6,8,11,14-eicosatetraenoic Acid Stimulates the Release of the Eosinophil Survival Factor Granulocyte/Macrophage Colony-stimulating Factor from Monocytes

Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model

The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor‐α and leukotriene B4 in a novel human whole blood assay

Clinical characteristics of COVID‐19 patients infected by the Omicron variants in Macao, China: A cross‐sectional study

In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Biological activity and preclinical efficacy of azetidinyl pyridazines as potent systemically-distributed stearoyl-CoA desaturase inhibitors

SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors

Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor

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