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Current approaches to enhancing oxime reactivator delivery into the brain

Toxicology (Amsterdam), 2019-07, Vol.423, p.75-83

2019

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Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review

Mini reviews in medicinal chemistry, 2015-01, Vol.15 (1), p.58-72

2015

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“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

Pharmacology & therapeutics (Oxford), 2022-08, Vol.236, p.108234-108234, Article 108234

Sakai, Toshiyuki

2022

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HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

ACS applied materials & interfaces, 2024-09, Vol.16 (38), p.50474-50483

2024

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Progress in the development of enzyme-based nerve agent bioscavengers

Chemico-biological interactions, 2013-12, Vol.206 (3), p.536-544

2013

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Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4079-4092

2020

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No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice

Chemico-biological interactions, 2024-04, Vol.392, p.110929-110929, Article 110929

2024

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Countermeasures in organophosphorus intoxication: pitfalls and prospects

Trends in pharmacological sciences (Regular ed.), 2022-07, Vol.43 (7), p.593-606

2022

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Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus

Toxicological sciences, 2019-06, Vol.169 (2), p.465-474

2019

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A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators

Life sciences (1973), 2020-01, Vol.240, p.117099-117099, Article 117099

2020

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EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

AL ULUM: JURNAL SAINS DAN TEKNOLOGI, 2023-08, Vol.9 (2), p.84

2023

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Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Accounts of chemical research, 2012-05, Vol.45 (5), p.756-766

2012

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Pharmacokinetics and pharmacodynamics of standard nerve agent medical countermeasures in Göttingen Minipigs

Toxicology letters, 2024-06, Vol.397, p.103-116

2024

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Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators

Toxicology and applied pharmacology, 2019-11, Vol.383, p.114776, Article 114776

2019

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Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs

Chemico-biological interactions, 2018-12, Vol.296, p.34-42

2018

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Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

The Journal of biological chemistry, 2012-04, Vol.287 (15), p.11798-11809

2012

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Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds

Current medicinal chemistry, 2009-06, Vol.16 (17), p.2177-2188

2009

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In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Medicinal chemistry (Shp-sariqah, United Arab Emirates), 2018-05, Vol.14 (3), p.281-292

2018

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Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction

Mini reviews in medicinal chemistry, 2007-05, Vol.7 (5), p.461-466

2007

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The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives

Chemico-biological interactions, 2024-05, Vol.395, p.110973-110973, Article 110973

2024

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Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication

Chemico-biological interactions, 2024-05, Vol.394, p.110941-110941, Article 110941

2024

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SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Biochimica et biophysica acta. General subjects, 2020-01, Vol.1864 (1), p.129440, Article 129440

2020

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Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase

Bioorganic & medicinal chemistry letters, 2023-11, Vol.96, p.129504-129504, Article 129504

2023

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Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase

European journal of medicinal chemistry, 2018-09, Vol.157, p.151-160

2018

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Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

Toxicology letters, 2016-03, Vol.246, p.1-6

2016

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Current approaches to enhancing oxime reactivator delivery into the brain

Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review

“RB-reactivator screening” as a novel cell-based assay for discoveries of molecular targeting agents including the first-in-class MEK inhibitor trametinib (trade name: Mekinist)

HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning

Progress in the development of enzyme-based nerve agent bioscavengers

Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve agents in mice

Countermeasures in organophosphorus intoxication: pitfalls and prospects

Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus

A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators

EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk

Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Pharmacokinetics and pharmacodynamics of standard nerve agent medical countermeasures in Göttingen Minipigs

Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators

Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs

Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction

The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives

Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations

Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase

Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase

Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase

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