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Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Aging (Albany, NY.), 2021-01, Vol.13 (3), p.4138-4156

2021

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Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess

The FASEB journal, 2024-04, Vol.38 (7), p.e23574-n/a

2024

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Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer

European journal of medicinal chemistry, 2023-02, Vol.247, p.115013, Article 115013

2023

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Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

European journal of medicinal chemistry, 2024-03, Vol.268, p.116193-116193, Article 116193

2024

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Research Progress of AR Gene Family in Prostate Cancer Therapy

Annals of urologic oncology, 2024-10, Vol.7, p.1-8

Khan, Maham

2024

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DAB2IP regulates intratumoral testosterone synthesis and CRPC tumor growth by ETS1/AKR1C3 signaling

Cellular signalling, 2022-07, Vol.95, p.110336-110336, Article 110336

2022

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Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

Biochemical pharmacology, 2018-10, Vol.156, p.22-31

2018

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Knockdown of AKR1C3 Promoted Sorafenib Sensitivity Through Inhibiting the Phosphorylation of AKT in Hepatocellular Carcinoma

Frontiers in oncology, 2022-03, Vol.12, p.823491-823491

2022

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Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors

ChemMedChem, 2024-11, Vol.19 (21), p.e202400081-n/a

2024

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Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome is not related to insulin or LH

Journal of endocrinology, 2019-04, Vol.241 (1), p.99-109

2019

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The In-Vitro Antitumor Effects of AST-3424 Monotherapy and Combination Therapy With Oxaliplatin or 5-Fluorouracil in Primary Liver Cancer

Frontiers in oncology, 2022-07, Vol.12, p.885139-885139

2022

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AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies

Frontiers in pharmacology, 2024, Vol.15, p.1378292-1378292

2024

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AKR1C3 promotes progression and mediates therapeutic resistance by inducing epithelial-mesenchymal transition and angiogenesis in small cell lung cancer

Translational oncology, 2024-09, Vol.47, p.102027, Article 102027

2024

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Androgens and endometrium: New insights and new targets

Molecular and cellular endocrinology, 2018-04, Vol.465, p.48-60

2018

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A Novel and Robust Prognostic Model for Hepatocellular Carcinoma Based on Enhancer RNAs-Regulated Genes

Frontiers in oncology, 2022-05, Vol.12, p.849242-849242

2022

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Single-cell analysis reveals that Jinwu Gutong capsule attenuates the inflammatory activity of synovial cells in osteoarthritis by inhibiting AKR1C3

Frontiers in physiology, 2022-11, Vol.13, p.1031996-1031996

2022

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Defining the biological functions and clinical significance of AKR1C3 in gastric carcinogenesis through multiomics functional analysis and immune infiltration analysis

Journal of Cancer, 2024-01, Vol.15 (9), p.2646-2658

2024

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Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration

Frontiers in physiology, 2022, Vol.13, p.844133-844133

2022

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Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Cell communication and signaling, 2020-01, Vol.18 (1), p.11-11, Article 11

2020

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Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3

ACS medicinal chemistry letters, 2019-04, Vol.10 (4), p.437-443

2019

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Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance

ACS medicinal chemistry letters, 2022-08, Vol.13 (8), p.1286-1294

2022

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ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3

Cell biology international, 2022-06, Vol.46 (6), p.965-975

2022

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Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats

Gene, 2018-07, Vol.662, p.1-9

2018

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The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone

The Journal of steroid biochemistry and molecular biology, 2024-02, Vol.236, p.106436-106436, Article 106436

2024

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ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells

Cancer science, 2017-10, Vol.108 (10), p.2011-2021

2017

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3-Hydroxysteroid Dehydrogenases - Metabolism
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Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess

Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer

Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

Research Progress of AR Gene Family in Prostate Cancer Therapy

DAB2IP regulates intratumoral testosterone synthesis and CRPC tumor growth by ETS1/AKR1C3 signaling

Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

Knockdown of AKR1C3 Promoted Sorafenib Sensitivity Through Inhibiting the Phosphorylation of AKT in Hepatocellular Carcinoma

Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors

Excess androgen production in subcutaneous adipose tissue of women with polycystic ovarian syndrome is not related to insulin or LH

The In-Vitro Antitumor Effects of AST-3424 Monotherapy and Combination Therapy With Oxaliplatin or 5-Fluorouracil in Primary Liver Cancer

AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies

AKR1C3 promotes progression and mediates therapeutic resistance by inducing epithelial-mesenchymal transition and angiogenesis in small cell lung cancer

Androgens and endometrium: New insights and new targets

A Novel and Robust Prognostic Model for Hepatocellular Carcinoma Based on Enhancer RNAs-Regulated Genes

Single-cell analysis reveals that Jinwu Gutong capsule attenuates the inflammatory activity of synovial cells in osteoarthritis by inhibiting AKR1C3

Defining the biological functions and clinical significance of AKR1C3 in gastric carcinogenesis through multiomics functional analysis and immune infiltration analysis

Klotho Polymorphism in Association With Serum Testosterone and Knee Strength in Women After Testosterone Administration

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3

Discovery of Novel Aldo-Keto Reductase 1C3 Inhibitors as Chemotherapeutic Potentiators for Cancer Drug Resistance

ARID3A promotes the chemosensitivity of colon cancer by inhibiting AKR1C3

Role of AKR1C3 in renal injury and glibenclamide is anti-inflammatory in preeclamptic rats

The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 catalyzes the activation of testosterone

ACSL3 promotes intratumoral steroidogenesis in prostate cancer cells

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