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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (13), p.6125-6129

1993

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A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1993-05, Vol.90 (10), p.4713-4717

1993

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Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-10, Vol.39 (22), p.4349-4353

1996

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Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.1034-1040

2000

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A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Biochemistry (Easton), 1996-07, Vol.35 (30), p.9737-9745

1996

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Oxazolidinones: a new class of antibacterials

Current Opinion in Pharmacology, 2001-10, Vol.1 (5), p.470-476

2001

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A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

The Journal of biological chemistry, 1991-11, Vol.266 (31), p.20583-20585

1991

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Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

Biochemistry (Easton), 1991-03, Vol.30 (10), p.2651-2655

1991

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Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6119-6124

1993

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An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Proceedings of the National Academy of Sciences - PNAS, 1990-10, Vol.87 (19), p.7472-7476

1990

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Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3793-3803

1998

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Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

Journal of Virology, 1993-09, Vol.67 (9), p.5353-5359

1993

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The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The Journal of biological chemistry, 1993-07, Vol.268 (20), p.14875-14880

1993

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The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Biochemical pharmacology, 1996-03, Vol.51 (6), p.743-750

1996

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Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Biochemistry (Easton), 1993-07, Vol.32 (26), p.6548-6554

1993

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Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Journal of medicinal chemistry, 1996-09, Vol.39 (19), p.3769-3789

1996

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Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

Biochemical pharmacology, 1994-06, Vol.47 (11), p.2017-2028

1994

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The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

The Journal of biological chemistry, 1992-01, Vol.267 (1), p.27-30

1992

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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Journal of Virology, 1996-06, Vol.70 (6), p.3698-3705

1996

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Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Proceedings of the National Academy of Sciences - PNAS, 1987-01, Vol.84 (2), p.546-550

1987

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Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

The Journal of infectious diseases, 1993-11, Vol.168 (5), p.1148-1156

1993

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Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2344-2356

1991

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Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

Biochemistry (Easton), 1996-02, Vol.35 (6), p.1911-1917

1996

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The Differential Processing of Homodimers of Reverse Transcriptases from Human Immunodeficiency Viruses Type 1 and 2 Is a Consequence of the Distinct Specificities of the Viral Proteases

The Journal of biological chemistry, 1995-06, Vol.270 (22), p.13573-13579

1995

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Association of Integrase, Matrix, and Reverse Transcriptase Antigens of Human Immunodeficiency Virus Type 1 with Viral Nucleic Acids Following Acute Infection

A Mutation in Reverse Transcriptase of Bis(heteroaryl)Piperazine-Resistant Human Immunodeficiency Virus Type 1 that Confers Increased Sensitivity to Other Nonnucleoside Inhibitors

Structure-Based Design of HIV Protease Inhibitors: Sulfonamide-Containing 5,6-Dihydro-4-hydroxy-2-pyrones as Non-Peptidic Inhibitors

Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant: Lead Identification and SAR of 3- and 4-Substituted Derivatives

A Drug Resistance Mutation in the Inhibitor Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impairs DNA Synthesis and RNA Degradation

Oxazolidinones: a new class of antibacterials

A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically active

Functional characterization of RNA-dependent DNA polymerase and RNase H activities of a recombinant HIV reverse transcriptase

(−)-6-Chloro-2-[(1-furo[2,3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E

An Inhibitor of the Protease Blocks Maturation of Human and Simian Immunodeficiency Viruses and Spread of Infection

Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

The quinoline U-78036 is a potent inhibitor of HIV-1 reverse transcriptase

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

Kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-88204E

Targeting Delavirdine/Atevirdine Resistant HIV-1: Identification of (Alkylamino)piperidine-Containing Bis(heteroaryl)piperazines as Broad Spectrum HIV-1 Reverse Transcriptase Inhibitors

Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E

The binding of a novel bisheteroarylpiperazine mediates inhibition of human immunodeficiency virus type 1 reverse transcriptase

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

Loss of Platelet-Derived Growth Factor-Stimulated Phospholipase Activity in NIH-3T3 Cells Expressing the EJ-ras Oncogene

Inhibition of the protease of human immunodeficiency virus blocks replication and infectivity of the virus in chronically infected macrophages

Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity

Characterization of the p68/p58 Heterodimer of Human Immunodeficiency Virus Type 2 Reverse Transcriptase

The Differential Processing of Homodimers of Reverse Transcriptases from Human Immunodeficiency Viruses Type 1 and 2 Is a Consequence of the Distinct Specificities of the Viral Proteases

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