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GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα12/13/RhoA Signaling

Journal of investigative dermatology, 2017-03, Vol.137 (3), p.727-736

2017

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Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

The Journal of biological chemistry, 2011-04, Vol.286 (16), p.14215-14225

2011

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Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation

Scientific reports, 2018-03, Vol.8 (1), p.4532-11, Article 4532

2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Nature (London), 1999-05, Vol.399 (6733), p.271-275

1999

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Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains

Molecular and Cellular Biology, 2012-04, Vol.32 (8), p.1408-1420

2012

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High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis

Journal of microbiology, immunology and infection, 2018-08, Vol.51 (4), p.485-491

2018

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Autocatalytic Cleavage of the EMR2 Receptor Occurs at a Conserved G Protein-coupled Receptor Proteolytic Site Motif

The Journal of biological chemistry, 2004-07, Vol.279 (30), p.31823-31832

2004

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The epidermal growth factor–like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans

Blood, 2003-10, Vol.102 (8), p.2916-2924

2003

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Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells

Frontiers in cell and developmental biology, 2020-05, Vol.8, p.414-414

2020

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Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility

Journal of cell science, 2016-06, Vol.129 (11), p.2156-2169

2016

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The Role of Receptor Oligomerization in Modulating the Expression and Function of Leukocyte Adhesion-G Protein-coupled Receptors

The Journal of biological chemistry, 2007-09, Vol.282 (37), p.27343-27353

2007

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CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells

Biochemical and biophysical research communications, 2007-02, Vol.353 (1), p.133-138

2007

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The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

Cell reports (Cambridge), 2016-05, Vol.15 (8), p.1757-1770

2016

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EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20

The Journal of biological chemistry, 2002-08, Vol.277 (32), p.29283-29293

2002

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Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif

FEBS letters, 2003-07, Vol.547 (1), p.145-150

2003

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Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

Frontiers in immunology, 2017-04, Vol.8, p.373-373

2017

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The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells

Journal of leukocyte biology, 2002-05, Vol.71 (5), p.854-862

2002

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GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell–cell aggregation

FEBS letters, 2011-01, Vol.585 (2), p.313-318

2011

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Site-specific N-glycosylation regulates the GPS auto-proteolysis of CD97

FEBS letters, 2009-10, Vol.583 (19), p.3285-3290

2009

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Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA

Protein expression and purification, 2015-05, Vol.109, p.85-92

2015

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Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival

Oncology reports, 2011-03, Vol.25 (3), p.619-627

2011

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GPS proteolytic cleavage of adhesion-GPCRs

Advances in experimental medicine and biology, 2010, Vol.706, p.49

2010

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Method for selecting and enriching cells expressing low affinity ligands for cell surface receptors

BioTechniques, 2005-05, Vol.38 (5), p.696-698

2005

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Multivalent protein probes for the identification and characterization of cognate cellular ligands for myeloid cell surface receptors

Methods in molecular biology (Clifton, N.J.), 2009, Vol.531, p.89

2009

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Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors

FEBS letters, 2008-03, Vol.582 (5), p.792-798

2008

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Receptors, G-Protein-Coupled - Metabolism
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Amino Acid Sequence
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Molecular Sequence Data
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Biophysics
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Receptors, G-Protein-Coupled - Chemistry
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Adhesion-Gpcr
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Epidermal Growth Factor - Chemistry
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GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα12/13/RhoA Signaling

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains

High levels of soluble GPR56/ADGRG1 are associated with positive rheumatoid factor and elevated tumor necrosis factor in patients with rheumatoid arthritis

Autocatalytic Cleavage of the EMR2 Receptor Occurs at a Conserved G Protein-coupled Receptor Proteolytic Site Motif

The epidermal growth factor–like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans

Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells

Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility

The Role of Receptor Oligomerization in Modulating the Expression and Function of Leukocyte Adhesion-G Protein-coupled Receptors

CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20

Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells

GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell–cell aggregation

Site-specific N-glycosylation regulates the GPS auto-proteolysis of CD97

Expression and immunoaffinity purification of recombinant soluble human GPR56 protein for the analysis of GPR56 receptor shedding by ELISA

Leukocyte adhesion-GPCR EMR2 is aberrantly expressed in human breast carcinomas and is associated with patient survival

GPS proteolytic cleavage of adhesion-GPCRs

Method for selecting and enriching cells expressing low affinity ligands for cell surface receptors

Multivalent protein probes for the identification and characterization of cognate cellular ligands for myeloid cell surface receptors

Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors

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