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PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

Cell, 2015-08, Vol.162 (5), p.1003-1015

2015

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The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes

Molecular cell, 2010-12, Vol.40 (5), p.689-701

2010

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Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification

Molecular cell, 2015-02, Vol.57 (4), p.685-694

2015

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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

Molecular and Cellular Biology, 2013-12, Vol.33 (23), p.4745-4754

2013

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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Nature genetics, 2017-11, Vol.49 (11), p.1647-1653

2017

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The super elongation complex (SEC) and MLL in development and disease

Genes & development, 2011-04, Vol.25 (7), p.661-672

2011

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An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

Environmental science & technology, 2017-08, Vol.51 (15), p.8713-8724

2017

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AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

Molecular cell, 2010-02, Vol.37 (3), p.429-437

2010

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Covalent modifications of histones during development and disease pathogenesis

Nature Structural & Molecular Biology, 2007-11, Vol.14 (11), p.1008-1016

2007

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Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

Cell, 2011-07, Vol.146 (1), p.92-104

2011

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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Nature genetics, 2020-06, Vol.52 (6), p.615-625

2020

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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Nature medicine, 2018-06, Vol.24 (6), p.758-769

2018

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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

Cell, 2018-10, Vol.175 (3), p.766-779.e17

2018

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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

Nature structural & molecular biology, 2013-09, Vol.20 (9), p.1093

2013

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The Little Elongation Complex Functions at Initiation and Elongation Phases of snRNA Gene Transcription

Molecular cell, 2013-08, Vol.51 (4), p.493-505

2013

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The Little Elongation Complex Regulates Small Nuclear RNA Transcription

Molecular cell, 2011-12, Vol.44 (6), p.954-965

2011

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Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

Molecular and cellular biology, 2015-03, Vol.35 (6), p.928-938

2015

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PAF1 regulation of promoter-proximal pause release via enhancer activation

Science (American Association for the Advancement of Science), 2017-09, Vol.357 (6357), p.1294-1298

2017

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Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

Molecular and Cellular Biology, 2009-11, Vol.29 (22), p.6074-6085

2009

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The COMPASS Family of H3K4 Methylases in Drosophila

Molecular and Cellular Biology, 2011-11, Vol.31 (21), p.4310-4318

2011

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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Cell, 2017-01, Vol.168 (1-2), p.59-72.e13

2017

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Clinical Manifestations and Management of Prune-belly Syndrome in a Large Contemporary Pediatric Population

Urology (Ridgewood, N.J.), 2015, Vol.85 (1), p.211-215

2015

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Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC)

Genes & development, 2011-07, Vol.25 (14), p.1486-1498

2011

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Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Genes & development, 2016-01, Vol.30 (1), p.92-101

2016

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Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Nature communications, 2018-10, Vol.9 (1), p.4406-13, Article 4406

2018

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PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II

The Chromatin Signaling Pathway: Diverse Mechanisms of Recruitment of Histone-Modifying Enzymes and Varied Biological Outcomes

Zic2 Is an Enhancer-Binding Factor Required for Embryonic Stem Cell Specification

The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

The super elongation complex (SEC) and MLL in development and disease

An “EAR” on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure–Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

Covalent modifications of histones during development and disease pathogenesis

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

The Little Elongation Complex Functions at Initiation and Elongation Phases of snRNA Gene Transcription

The Little Elongation Complex Regulates Small Nuclear RNA Transcription

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

PAF1 regulation of promoter-proximal pause release via enhancer activation

Global Analysis of H3K4 Methylation Defines MLL Family Member Targets and Points to a Role for MLL1-Mediated H3K4 Methylation in the Regulation of Transcriptional Initiation by RNA Polymerase II

The COMPASS Family of H3K4 Methylases in Drosophila

Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia

Clinical Manifestations and Management of Prune-belly Syndrome in a Large Contemporary Pediatric Population

Dynamic transcriptional events in embryonic stem cells mediated by the super elongation complex (SEC)

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity

Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

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